| Project/Area Number |
26461585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
難波 ひかる 岡山大学, 医歯薬学総合研究科, 助教 (20273972)
八代 将登 岡山大学, 大学病院, 助教 (80585943)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | インフルエンザ / VNN1 / インフルエンザウイルス / 血管内皮細胞 |
|---|
| Outline of Final Research Achievements |
Results: (i) Increased expression of IL-11, Fas L, Angiotensin II receptor genes was observed in vascular endothelial cells, when influenza virus infected the respiratory epithelium (in vitro）. It was thought to be an influenza virus specific response. (ii) VNN1 was newly identified as a gene involved in influenza virus replication in the respiratory epithelium. VNN1 is an enzyme that hydrolyzes pantetheine, and it was found that cysteamine which is a degradation product of pantetheine, has a virus replication inhibiting action.
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