Transmission of virulence and antibiotic resistance genes among Enteroaggregative Escherichia coli strains isolated from children
Project/Area Number |
26461589
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Kagoshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
藺牟田 直子 鹿児島大学, 医歯学域医学系, 助教 (00643470)
大岡 唯祐 鹿児島大学, 医歯学域医学系, 講師 (50363594)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | Escherichia coli / EAEC / ESBL / K1 capsule / 基質拡張型βラクタマーゼ(ESBL) / 大腸菌 / K1莢膜 / 腸管凝集性大腸菌 / 腸管病原性大腸菌 / 下痢原性大腸菌 / 尿路病原性大腸菌 / 基質拡張型βラクタマーゼ / MLSA / ゲノム解析 / 遺伝的多様性 |
Outline of Final Research Achievements |
We performed phylogenetic analysis of entereaggregative Escherichia coli (EAEC) 167 strains isolated in Japan and found five major clones including an EAEC/UPEC (uropathogencic E. coli) hybrid clone O25:H4/ST131 possessing extend-spectrum beta-lactamase (ESBL) blaCTX-M gene. The incidence of blaCTX-M-positive strains among E. coli isolates from diarrheal children increases since 2013, and reached to 10.7% in 2013. Pathogenic genes among blaCTX-M-positive E. coli strains were as follows: EAEC aggR, 19%; EPEC (enteropathogenic E. coli) eae, 0.01%; K1 capsule gene neuC, 15.1%. These results suggest the pronounced horizontal transfer of blaCTX-M and pathogenic genes.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Phylogenetic analysis of enteroaggregative Escherichia coli (EAEC) isolates from Japan reveals emergence of CTX-M-14-producing EAEC O25:H4 clones related to sequence type 131.2016
Author(s)
Imuta N, Ooka T, Seto K, Kawahara R, Koriyama T, Kojyo T, Iguchi A, Tokuda K, Kawamura H, Yoshiie K, Ogura Y, Hayashi T, Nishi J
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Journal Title
J Clin Microbiol
Volume: 54(8)
Issue: 8
Pages: 2128-2134
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Defining the Genome Features of Escherichia albertii, an Emerging Enteropathogen Closely Related to Escherichia coli2015
Author(s)
Ooka T, Ogura Y, Katsura K, Seto K, Kobayashi H, Kawano K, Tokuoka E, Furukawa M, Harada S, Yoshino S, Seto J, Ikeda T, Yamaguchi K, Murase K, Gotoh Y, Imuta N, Nishi J, Gomes TA, Beutin L, Hayashi T.
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Journal Title
Genome Biol Evol
Volume: 7(12)
Pages: 3170-3179
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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