| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
1) von Willebrand factor (VWF) plays a dominant role in shear stress mediated thrombus formation. Factor VIII (FVIII) alone did not improve thrombus under high shear. However, in the presence of VWF, FVIII improved thrombus formation, suggesting the importance of FVIII/ VWF interaction in thrombus formation under high shear. 2) We succeeded the culture of endothelial cells (ECs) under shear conditions. ECs demonstrated round shape under static condition and string-like elongated shape under laminar shear condition. Under disturbed flow condition which does not have the clear direction, ECs demonstrated various shapes including round shape to elongated shape which does not have the directions.
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