Regulation of the function of endothelial cells by shear stress
| Project/Area Number |
26461593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nara Medical University |
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Principal Investigator |
shida yasuaki 奈良県立医科大学, 医学部, 助教 (10721566)
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| Co-Investigator(Kenkyū-buntansha) |
野上 恵嗣 奈良県立医科大学, 医学部, 准教授 (50326328)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 血流 / ずり応力 / 凝固 / 血栓 / 血管内皮細胞 / 血友病 / ヴォン･ヴィレブランド病 / フォン･ヴィレブランド病 |
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| Outline of Final Research Achievements |
1) von Willebrand factor (VWF) plays a dominant role in shear stress mediated thrombus formation. Factor VIII (FVIII) alone did not improve thrombus under high shear. However, in the presence of VWF, FVIII improved thrombus formation, suggesting the importance of FVIII/ VWF interaction in thrombus formation under high shear. 2) We succeeded the culture of endothelial cells (ECs) under shear conditions. ECs demonstrated round shape under static condition and string-like elongated shape under laminar shear condition. Under disturbed flow condition which does not have the clear direction, ECs demonstrated various shapes including round shape to elongated shape which does not have the directions.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Successful haemostatic management of replacement of the ascending aorta for type A acute aortic dissection in a patient with mild haemophilia B2016
Author(s)
Takeyama M, Nogami K, Shida Y, Yada K, Hirose T, Hayata Y, Tabayashi N, Taniguchi S, Akasaki Y, Kawaraguchi Y, Kawaguchi M, Shima M
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Journal Title
Haemophilia
Volume: Jan 29
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation2015
Author(s)
1)Shida Y, Rydz N, Stegner D, Brown C , Mewburn J, Sponagle K , Danisment Ozge, Crawford B, Vidal B, Hegadorn C, Pruss C, Nieswandt B and Lillicrap D
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Journal Title
Blood
Volume: 124(11)
Issue: 11
Pages: 1799-1807
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A2014
Author(s)
Muto A, Yoshihashi K, Takeda M, Kitazawa T, Soeda T, Igawa T, Sampei Z, Kuramochi T, Sakamoto A, Haraya K, Adachi K, Kawabe Y, Nogami K, Shima M, Hattori K.
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Journal Title
Blood
Volume: 124(20)
Issue: 20
Pages: 3165-71
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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