| Project/Area Number |
26461601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Defense Medical College |
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Principal Investigator |
KAWAGUCHI HIROYUKI 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 小児科学, 准教授 (00313130)
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| Co-Investigator(Kenkyū-buntansha) |
宮内 潤 東京歯科大学, 歯学部, 客員教授 (20146707)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | neuroblastoma / NIPA (ZC3HC1) / MYCN / NIPA / ALK / 神経芽細胞腫 / 増殖 / 分化 / 造血幹細胞 / 加齢 / 横紋筋肉腫 / 遺伝子発現 / 細胞周期 / ユビキチン化 / 細胞増殖 / ユーイング肉腫 / 小児がん |
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| Outline of Final Research Achievements |
No functional relevance between NIPA (ZC3HC1) protein and MYCN protein could be proved. Neuroblastoma cell lines could be divided into two groups: ones which show suppressed proliferation by silencing NIPA (group A; SK-N-DZ, CHP-212, GOTO, SK-N-MC), and ones which do not (group B; SK-N-AS, KELLY, TGW, IMR-32, NB-39nu). No common biological feature in these two groups could not be specified. Although 49 genes that show upregulation or down regulation with silencing were identified, no significant impact on pathogenesis of neuroblastoma could not identified.
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