| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We found that in the liver from infants with biliary atresia, the expression level of beta-defensin, an antimicrobial peptide which activates innate immunity against gram-negative bacteria was upregulated compared to livers from diseased and normal controls. The expression level of its receptor, TLR4 was identified on hepatic dendritic cells.
In the rotavirus-induced murine model of biliary atresia, when we kept the colony under bactrim diet, the incidence of obstruction of extrahepatic bile duct was reduced significantly after injection of rotavirus, and a part of gram negative bacteria was decreased in the stool of mouse from the bactrim-diet colony.
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