(Pro)renin receptor-mediated pathophysiology in crescentic nephritis

• Project/Area Number: 26461612
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: URUSHIHARA Maki 徳島大学, 病院, 講師 (50403689)
• Co-Investigator(Kenkyū-buntansha): 香美 祥二 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (00224337)
• Research Collaborator: NAGAI Takashi
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アンジオテンシン / 半月体形成性腎炎 / レニン

Outline of Final Research Achievements

To examine whether direct renin inhibition ameliorate renal injury in crescentic glomerulonephritis, we investigated the effects on renal injury in experimental animal model. As a result, glomerular crescents rates and proteinuria were reduced by the treatment with direct renin inhibitor. Furthermore, primary cultured glomerular cells indicated cell proliferation and macrophage infiltration via (pro)renin receptor. These results suggest that therapeutic strategy of direct renin inhibition may prove beneficial for crescent GN and the novel mechanism via (pro)renin receptor are involved in glomerular crescent formation.