| Project/Area Number |
26461624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大橋 隆治 日本医科大学, 医学部, 准教授 (00328783)
小川 俊一 日本医科大学, 医学部, 教授 (50194436)
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| Co-Investigator(Renkei-kenkyūsha) |
Ohno Naohito 東京薬科大学, 薬学部, 教授 (80152213)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 川崎病 / マウス血管炎 / CAWS / Nod-1 / FK565 / 血管炎 / TNF / IL-1 / TNF alpha / IL-1 beta / NF kappa B / サイトカインプロファイリング / TNFノックアウトマウス |
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| Outline of Final Research Achievements |
Kawasaki disease (KD) is systemic vasculitis mainly affected infant and its etiology is still unknown. This study tries to elucidate the mechanism how KD vasculitis is induced, using KD model mouse. We used Candida Albicans Water Soluble Fraction (CAWS) and Nod-1 ligand, FK565, to induce vasculitis. Anti-mouse IL-1βantibody attenuated the occurrence of vasculitis caused by CAWS. Together with preliminary data, IL-1βand TNF played very important roles for inducing CAWS vasculitis. On the other hand, FK565 induced more severe vasculitis in coronary arteries, and the severity of vasculitis significantly correlated with serum IL-1βconcentration.
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