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Elucidate the mechanism how Kawasaki disease vasculitis occur

Research Project

Project/Area Number 26461624
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionNippon Medical School

Principal Investigator

Fukazawa Ryuji  日本医科大学, 医学部, 准教授 (80277566)

Co-Investigator(Kenkyū-buntansha) 大橋 隆治  日本医科大学, 医学部, 准教授 (00328783)
小川 俊一  日本医科大学, 医学部, 教授 (50194436)
Co-Investigator(Renkei-kenkyūsha) Ohno Naohito  東京薬科大学, 薬学部, 教授 (80152213)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords川崎病 / マウス血管炎 / CAWS / Nod-1 / FK565 / 血管炎 / TNF / IL-1 / TNF alpha / IL-1 beta / NF kappa B / サイトカインプロファイリング / TNFノックアウトマウス
Outline of Final Research Achievements

Kawasaki disease (KD) is systemic vasculitis mainly affected infant and its etiology is still unknown. This study tries to elucidate the mechanism how KD vasculitis is induced, using KD model mouse. We used Candida Albicans Water Soluble Fraction (CAWS) and Nod-1 ligand, FK565, to induce vasculitis. Anti-mouse IL-1βantibody attenuated the occurrence of vasculitis caused by CAWS. Together with preliminary data, IL-1βand TNF played very important roles for inducing CAWS vasculitis. On the other hand, FK565 induced more severe vasculitis in coronary arteries, and the severity of vasculitis significantly correlated with serum IL-1βconcentration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (9 results) Book (5 results)

  • [Journal Article] Characterization of a murine model with arteritis induced by Nod1 ligand, FK565: a comparative study with a CAWS-induced model2017

    • Author(s)
      Ohashi, R. Fukazawa, R. Watanabe, M. Hashimoto, K. Suzuki, N. Nagi-Miura, N. Ohno, N. Shimizu, A. Itoh, Y.
    • Journal Title

      Mod Rheumatol

      Volume: 2017 Issue: 6 Pages: 1-19

    • DOI

      10.1080/14397595.2017.1287150

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 【慢性疾患児の一生を診る】川崎病に合併した冠動脈後遺症2016

    • Author(s)
      阿部正徳、深澤隆治
    • Journal Title

      小児内科

      Volume: 48 Pages: 1484-87

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Variations in ORAI1 Gene Associated with Kawasaki Disease2016

    • Author(s)
      Onouchi Y, Fukazawa R, Yamamura K, Suzuki H, Kakimoto N, Suenaga T, et al.
    • Journal Title

      PloS One

      Volume: 11 Issue: 1 Pages: e0145486-e0145486

    • DOI

      10.1371/journal.pone.0145486

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 日本小児循環器学会所属施設における心臓カテーテル検査・インターベンションの深鎮静に関する全国調査2014

    • Author(s)
      三浦大、賀藤均、土井庄三郎、朴仁三、中川雅生、藤原優子、住友直方、深澤隆治、水上愛弓、松裏裕行、安河内聰、清澤伸幸
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 30 Pages: 580-7

    • NAID

      130004700083

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Candida Albicans Water Soluble Fractionによるマウス川崎病血管炎モデルにおいて Tumor Necrosis Factor Alphaは中心的役割を果たす2016

    • Author(s)
      鈴木 伸子, 深澤 隆治, 橋本 佳亮, 渡邉 誠, 赤尾 見春、上砂 光裕, 勝部 康弘, 阿部 正徳, 三浦 典子, 大野尚仁、小川俊一
    • Organizer
      第52回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] TNFはCandida Albicans Water Soluble Fractionによる血管炎を惹起するために必須である2015

    • Author(s)
      鈴木伸子、深澤隆治、渡邉誠、橋本佳昭、赤尾見春、上砂光裕、勝部康弘、小川俊一
    • Organizer
      第35回日本川崎病学会・学術集会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Candida Albicans Water Soluble Fraction(CAWS)血管炎川崎病モデルと川崎病との類似点・相違点の検証2015

    • Author(s)
      深澤隆治、渡邉誠、橋本佳昭、池上英、赤尾見春、阿部正徳、上砂光裕、勝部康弘、三浦典子、大野尚人、小川俊一
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Thrombotic Risk Assessment in Kawasaki Disease Patients with Coronary Artery Aneurysms usin Transluminal Attenuation Gradient Analysis2015

    • Author(s)
      Gutierrez NG, Kahn AM, Shirinsky O, Lyskina GA, Fukazawa R, Ogawa S, Burns JC, Marsden AL
    • Organizer
      International Kawasaki Disease Symposium
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Fate of Kawasaki disease giant coronary aneurysm: Analysis of the last 10 years nationwide survey in Japan2015

    • Author(s)
      Fukazawa R, Hamaoka K, Saji T, Kato H, Suzuki E, Tsuda E, Ayusawa M, Miura M, Kobayashi T, Ogawa S
    • Organizer
      International Kawasaki Disease Symposium
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Candida Albicans Water Soluble Fraction (CAWS) による血管炎は川崎病モデルといえるのか?2014

    • Author(s)
      深澤隆治、渡邉誠、阿部正徳、赤尾見春、池上英、上砂光裕、勝部康弘、小川俊一
    • Organizer
      第34回日本川崎病学会学術集会
    • Place of Presentation
      東京、日本
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Cardiac death and myocardial infarction on Kawasaki disease with giant coronary aneurysm: Analysis of recent nationwide survey in Japan2014

    • Author(s)
      Fukazawa R, Hamaoka K, Saji T, Kato H, Suzuki E, Ayusawa M, Miura M, Kobayashi T, Ogawa S
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Histological and rheological evaluation at coronary artery lesions in patients with Kawasaki disease2014

    • Author(s)
      Watanabe M, Ogawa S, Fukazawa R, Ohkubo Y Katsube M, Kamisago M, Ikegami E, Abe M, Akao M
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 巨大冠動脈瘤を有する川崎病既往者における成人期の問題点2014

    • Author(s)
      深澤隆治、渡邉誠、橋本康司、林美雪、阿部正徳、池上英、大久保隆志、赤尾見春、上砂光裕、勝部康弘、小川俊一
    • Organizer
      第50回に本章に循環器学会学術集会
    • Place of Presentation
      岡山、日本
    • Year and Date
      2014-07-03 – 2014-07-05
    • Related Report
      2014 Research-status Report
  • [Book] Part IV Diagnosis and Examinations, Promising Biomarkers in Kawasaki Disease and Acute Coronary Ischemia, Kawasaki Disease2017

    • Author(s)
      Fukazawa R
    • Total Pages
      552
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] 今日の小児治療指針 第16版 9免疫疾患、膠原病 川崎病(冠動脈病変を除く)2015

    • Author(s)
      深澤隆治
    • Total Pages
      1006
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Book] 小児疾患診療のための病態整理2 改定第5版 VIII リウマチ性疾患とその周辺疾患:川崎病2015

    • Author(s)
      深澤隆治
    • Total Pages
      1071
    • Publisher
      東京医学社
    • Related Report
      2015 Research-status Report
  • [Book] 小児科臨床ピクシス9 川崎病のすべて 第6章心臓血管後遺症 巨大冠動脈瘤:自然歴2015

    • Author(s)
      深澤隆治
    • Total Pages
      261
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Book] 小児科臨床ピクシス9 川崎病のすべて 第6章心臓血管後遺症 巨大冠動脈瘤:抗凝固療法2015

    • Author(s)
      深澤隆治
    • Total Pages
      261
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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