| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In this study, we investigated whether individual differences in mizoribine (MZR) absorption are related to gene polymorphisms of hCNT1, hCNT2, hCNT 3. There was no clear significant relationship between gene polymorphisms of hCNT 1, 2, 3 and MZR blood concentrations. There was no clear significant relationship between each combination of gene polymorphisms of hCNT 1, 2, 3 and MZR blood concentration. Even in the study divided into MZR blood level elevation cases and non-elevation cases, there was no dominant relationship between gender and hCNT 1, 2, 3 gene polymorphism. From the above results, it was found that no clear relationship was found between MZR blood concentrations in hCNT1, hCNT2, and hCNT 3 gene polymorphisms and combinations, respectively.
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