A multicenter collaborative study to establish the criteria for phototherapy in extremely preterm infants

• Project/Area Number: 26461633
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kobe University
• Principal Investigator: Nakamura Hajime 神戸大学, 医学研究科, 名誉教授 (40030978)
• Co-Investigator(Kenkyū-buntansha): 岡田 仁 香川大学, 医学部附属病院, 助手 (30253272) ; 吉村 健一 金沢大学, 附属病院, 特任教授 (30415517) ; 細野 茂春 日本大学, 医学部, 准教授 (50339339) ; 森岡 一朗 神戸大学, 医学研究科, 特命教授 (80437467)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 光線療法 / 適応基準 / 多施設共同研究 / 治療基準 / 早産児 / 新生児黄疸 / 核黄疸 / 高ビリルビン血症 / 交換輸血 / アンバウンドビリルビン

Outline of Final Research Achievements

In 1991, Kobe University proposed treatment criteria for hyperbilirubinemic newborns using total serum bilirubin and serum unbound bilirubin reference values. In the last decade, chronic bilirubin encephalopathy (kernicterus) has found to develop in preterm infants in Japan. First, we revised the criteria of phototherapy for preterm hyperbilirubinemic infants. Secondly, we performed a multicenter collaborative prospective cohort study to confirm if chronic bilirubin encephalopathy can be prevented by using the revised criteria. One hundred fifty preterm infants who were born <30 weeks of gestations were enrolled. The infants performed phototherapy were decreased and there were no infants developing chronic bilirubin encephalopathy.

Research Products

• [Int'l Joint Research] スタンフォード大学(米国)
• [Int'l Joint Research] スタンフォード大学(米国)
• [Journal Article] Monitoring Bilirubin Binding Parameters in a Cohort of Japanese Neonates. (2018)
  • Author(s): Morioka I, Kurokawa D, Iwatani S, Iijima K, Nakamura H, Lamola AA, Bhutani VK, Wong RJ, Stevenson DK
  • Journal Title: Journal of Clinical and Laboratory Medicine Volume: 2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] UGT1A1遺伝子G71Rヘテロ接合変異を有し、完全母乳栄養中に遷延性高ビリルビン血症を呈した一絨毛膜二羊膜性双胎の早産児例 (2018)
  • Author(s): 大山正平、八木佑加子、山名啓司、藤岡一路、飯島一誠、岡橋 彩、中村 肇、森岡一朗
  • Journal Title: 小児科臨床 Volume: -
  • Peer Reviewed
• [Journal Article] Evaluation of BiliCare transcutaneous bilirubin device in Japanese newborns. (2017)
  • Author(s): Yamana K, Morioka I, Kurokawa D, Fukushima S, Nishida K, Ohyama S, Nishimura N, Nozu K, Taniguchi-Ikeda M, Nagase H, Fujioka K, Iwatani S, Nakamura H, Iijima K.
  • Journal Title: Pediatr Int. Volume: 59(10) Issue: 10 Pages: 1058-1063
  • DOI: 10.1111/ped.13364
  • Peer Reviewed
• [Journal Article] インタクトサバイバル時代の早産児の黄疸管理・治療とアンバウンドビリルビン (2017)
  • Author(s): 森岡一朗、岩谷壮太、黒川大輔、中村 肇
  • Journal Title: 日本小児科学会雑誌 Volume: 121 Pages: 1491-99
  • Peer Reviewed
• [Journal Article] 早産児の黄疸管理～新しい管理方法と治療基準の考案 (2017)
  • Author(s): 森岡一朗、岩谷壮太、香田 翼、中村 肇
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 53 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Fluorescent protein-based detection of unconjugated bilirubin in newborn serum (2016)
  • Author(s): Sota Iwatani, Hajime Nakamura, Daisuke Kurokawa, Keiji Yamana, Kosuke Nishida, Sachiyo Fukushima, Tsubasa Koda, Noriyuki Nishimura, Hisahide Nishio, Kazumoto Iijima, Atsushi Miyawaki, Ichiro Morioka
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 1-8
  • DOI: 10.1038/srep28489
  • NAID: 120005819328
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transcutaneous bilirubin monitoring detects unexpected late-onset hemolysis in a very low birthweight infant. (2016)
  • Author(s): Nagasaka M, Kikuma T, Iwatani S, Kurokawa D, Yamana K, Maeyama K, Koda T, Matsumoto H, Taniguchi-Ikeda M, Iijima K, Nakamura H, Morioka I
  • Journal Title: BMC Res Notes. Volume: 9 Issue: 1 Pages: 153-153
  • DOI: 10.1186/s13104-016-1970-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Screening for hyperbilirubinemia in Japanese very low birthweight infants using transcutaneous bilirubinometry. (2016)
  • Author(s): Kurokawa D, Nakamura H, Yokota T, Iwatani S, Morisawa T, Katayama Y, Sakai H, Ioroi T, Iijima K, Morioka I
  • Journal Title: J Pediatr. Volume: 168 Pages: 77-81
  • DOI: 10.1016/j.jpeds.2015.08.038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] International Perspectives: Clinical kernicterus in preterm infants in Japan. (2016)
  • Author(s): Morioka I, Nakamura H, Iwatani S, Wong RJ, Iijima K
  • Journal Title: NeoReviews. Volume: 17 Issue: 3 Pages: e124-e130
  • DOI: 10.1542/neo.17-3-e124
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Disorder of bilirubin binding to albumin and bilirubin-induced neurological dysfunction. (2015)
  • Author(s): Morioka I., Iwatani S., Koda T., Iijima K., Nakamura H
  • Journal Title: Semin Fetal Neonatal Med. Volume: 20 Issue: 1 Pages: 31-36
  • DOI: 10.1016/j.siny.2014.11.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of HMOX1 gene promoter polymorphisms with hyperbilirubinemia in the early neonatal period. (2015)
  • Author(s): Katayama Y., Yokota T., Zhao H., Wong RJ., Stevenson DK., Taniguchi-Ikeda M., Nakamura H., Iijima K., Morioka I
  • Journal Title: Pediatr Int. Volume: 57 Issue: 4 Pages: 645-649
  • DOI: 10.1111/ped.12591
  • Peer Reviewed / Open Access
• [Journal Article] Serum unbound bilirubin as a predictor for clinical kernicterus in extremely low birth weight infants at a late age in the neonatal intensive care unit. (2015)
  • Author(s): Morioka I., Nakamura H., Koda T., Sakai H., Kurokawa D., Yonetani M., Morisawa T., Katayama Y., Wada H., Funato M., Takatera A., Okumura A., Sato I., Kawano S., Iijima K
  • Journal Title: Brain Dev. Volume: 37 Issue: 8 Pages: 753-757
  • DOI: 10.1016/j.braindev.2015.01.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Current incidence of clinical kernicterus in preterm infants in Japan. (2015)
  • Author(s): Morioka I, Nakamura H, Koda T, Yokota T, Okada H, Katayama Y, Kunikata T, Kondo M, Nakamura M, Hosono S, Yasuda S, Yokoyama N, Wada H, Itoh S, Funato M, Yamauchi Y, Kye Lee Y, Yonetani M
  • Journal Title: Pediatr Int. Volume: 57
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 我が国の超早産児に対する黄疸管理と治療の現状 (2015)
  • Author(s): 森岡一朗、中村 肇、香田 翼、横田知之、岡田 仁、片山義規、國方徹也、近藤昌敏、中村 信、細野茂春、安田真之、横山直樹、和田 浩、伊藤 進、船戸正久、山内芳忠、李 容桂、米谷昌彦
  • Journal Title: 日本新生児成育医学会雑誌 Volume: 27
  • NAID: 40021132098
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Postnatal serum concentrations of endogenous free fatty acids in newborns admitted to the neonatal intensive care unit: Effects on unbound bilirubin. (2014)
  • Author(s): Koda T., Morioka I., Yokota T., Kurokawa D., Fujita K., Nagasaka M., Matsuo K., Shibata A., Sato I., Kawano S., Yamada H., Nakamura H., Iijima K.
  • Journal Title: Ann Clin Biochem. Volume: 51 Issue: 6 Pages: 680-68
  • DOI: 10.1177/0004563214522771
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 新生児黄疸の再評価 (2014)
  • Author(s): 中村 肇、森岡一朗
  • Journal Title: 周産期医学 発行確定 Volume: 44 Pages: 1285-89
  • Open Access
• [Presentation] ミニシンポジウム「早産低出生体重児と高ビリルビン血症」、早産児の総ビリルビン・アンバウンドビリルビンを用いた光線療法・交換輸血治療基準の評価 (2017)
  • Author(s): 森岡一朗、香田 翼、岩谷壮太、黒川大輔、山名啓司、西田浩輔、大山正平、藤岡一路、飯島一誠、中村 肇
  • Organizer: 第53回日本周産期新生児医学会
• [Presentation] ミニシンポジウム「早産低出生体重児と高ビリルビン血症」、早産児における新生児黄疸治療の適応基準確立のための多施設共同研究 (2017)
  • Author(s): 森岡一朗、岩谷壮太、前山花織、藤岡一路、飯島一誠、横田知之、森沢 猛、三輪明弘、五百蔵智明、大久保沙紀、芳本誠司、岡田 仁、吉川香代、細野茂春、中村 肇
  • Organizer: 第53回日本周産期新生児医学会
• [Presentation] ミニシンポジウム「早産低出生体重児と高ビリルビン血症」、UBアナライザーとニホンウナギ由来の蛍光タンパク質（UnaG）を用いた新たなアンバウンドビリルビン測定法の開発 (2017)
  • Author(s): 岩谷壮太、中村肇、大山正平、西田浩輔、山名啓司、黒川大輔、藤岡一路、西村範行、飯島一誠、森岡一朗
  • Organizer: 第53回日本周産期新生児医学会
• [Presentation] シンポジウム「早産児核黄疸：現状と対策」、早産児黄疸管理の現状と課題：いま、なぜ核黄疸？ (2016)
  • Author(s): 中村 肇
  • Organizer: 第61回日本新生児成育医学会
  • Place of Presentation: 大阪
  • Year and Date: 2016-12-01
• [Presentation] 近年NICUで使用される各種薬剤のビリルビン・アルブミン結合に及ぼす影響 (2016)
  • Author(s): 黒川大輔、大山正平、福嶋祥代、西田浩輔、山名啓司、岩谷壮太、藤岡一路、中村 肇、飯島一誠、森岡一朗
  • Organizer: 第61回日本新生児成育医学会
  • Place of Presentation: 大阪
  • Year and Date: 2016-12-01
• [Presentation] ビルメータFの総ビリルビン値の正確性に関する検討 (2016)
  • Author(s): 山名啓司、岩谷壮太、大山正平、西田浩輔、黒川大輔、藤岡一路、中村 肇、飯島一誠、森岡一朗
  • Organizer: 第61回日本新生児成育医学会
  • Place of Presentation: 大阪
  • Year and Date: 2016-12-01
• [Presentation] 耳介を挟んで測定する経皮黄疸計：測定部位に関する検討 (2016)
  • Author(s): 山名啓司、岩谷壮太、福嶋祥代、德田央士、前山花織、西田浩輔、黒川大輔、長坂美和子、香田 翼、中村 肇、飯島一誠、森岡一朗
  • Organizer: 第52回日本周産期・新生児医学会
  • Place of Presentation: 富山
  • Year and Date: 2016-07-16
• [Presentation] 耳介を挟んで測定する経皮黄疸計：測定値と測定者間のばらつきに関する検討 (2016)
  • Author(s): 山名啓司、岩谷壮太、福嶋祥代、德田央士、前山花織、西田浩輔、黒川大輔、長坂美和子、香田 翼、中村 肇、飯島一誠、森岡一朗
  • Organizer: 第52回日本周産期・新生児医学会
  • Place of Presentation: 富山
  • Year and Date: 2016-07-16
• [Presentation] 核黄疸発症症例からみた新生児集中治療室入院中の早産児黄疸管理方法の提案 (2016)
  • Author(s): 森岡一朗、岩谷壮太、香田 翼、長坂美和子、黒川大輔、山名啓司、藤田花織、西田浩輔、中村 肇、飯島一誠
  • Organizer: 第119回日本小児科学会
  • Place of Presentation: 札幌
  • Year and Date: 2016-05-13
• [Presentation] Incidence of kernicterus in Japanese preterm infants <30 wks gestation born in 2011. (2016)
  • Author(s): Morioka I, Nakamura H, Okada H, Katayama Y, Kunikata T, Kondo M, Nakamura M, Hosono S, Yasuda S, Yokoyama N, Wada H, Yonetani M
  • Organizer: Pediatric Academic Society Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-04-30
  • Int'l Joint Research
• [Presentation] A novel method for measuring unbound serum bilirubin levels using glucose oxidase-peroxidase and bilirubin-inducible fluorescent protein. (2016)
  • Author(s): Iwatani S, Nakamura H, Fukushima S, Tokuda O, Nishida K, Fujita-Maeyama K, Yamana K, Kurokawa D, Nagasaka M, Koda T, Iijima K, Miyawaki A, Morioka I
  • Organizer: Pediatric Academic Society Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-04-30
  • Int'l Joint Research
• [Presentation] Unbound bilirubin levels determined by hematofluorometry. (2016)
  • Author(s): Kurokawa D, Iwatani S, Fukushima S, Tokuda O, Maeyama K, Nishida K, Yamana K, Nagasaka M, Koda T, Nakamura H, Iijima K, Morioka I
  • Organizer: Pediatric Academic Society Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-04-30
  • Int'l Joint Research
• [Presentation] Unbound bilirubin measurements by the glucose oxidase-peroxidase method is affected by direct bilirubin/total bilirubin ratios. (2016)
  • Author(s): Yamana K, Iwatani S, Fukushima S, Tokuda O, Nishida K, Maeyama K, Kurokawa D, Nagasaka M, Koda T, Morisawa T, Mizobuchi M, Iijima K, Nakamura H, Morioka I
  • Organizer: Pediatric Academic Society Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-04-30
  • Int'l Joint Research
• [Presentation] 血清総ビリルビン値とアンバウンドビリルビン値を用いた黄疸治療基準の評価 (2015)
  • Author(s): 香田 翼、中村 肇、福嶋祥代、德田央士、西田浩輔、藤田花織、黒川大輔、長坂美和子、山名啓司、岩谷壮太、飯島一誠、森岡一朗
  • Organizer: 第60回日本新生児成育医学会
  • Place of Presentation: 盛岡
  • Year and Date: 2015-10-23
• [Presentation] GOD-POD法を用いたUB測定値は抱合型ビリルビン/総ビリルビン比により影響される (2015)
  • Author(s): 山名啓司、岩谷壮太、福嶋祥代、德田央士、藤田花織、西田浩輔、黒川大輔、長坂美和子、香田 翼、森沢 猛、溝渕雅巳、中村 肇、飯島一誠、森岡一朗
  • Organizer: 第60回日本新生児成育医学会
  • Place of Presentation: 盛岡
  • Year and Date: 2015-10-23
• [Presentation] UBアナライザーとビリルビン誘導蛍光タンパク質（UnaG）を用いた新たなアンバウンドビリルビン測定法の開発 (2015)
  • Author(s): 岩谷壮太、中村 肇、福嶋祥代、德田央士、西田浩輔、藤田花織、山名啓司、黒川大輔、長坂美和子、香田 翼、西村範行、飯島一誠、森岡一朗
  • Organizer: 第60回日本新生児成育医学会
  • Place of Presentation: 盛岡
  • Year and Date: 2015-10-23
• [Presentation] 全血前面蛍光分析法とグルコース・ペルオキシダーゼ法によるUB値の相関性 (2015)
  • Author(s): 黒川大輔、岩谷壮太、福嶋祥代、徳田央士、藤田花織、西田浩輔、山名啓司、長坂美和子、香田 翼、中村 肇、飯島一誠、森岡一朗
  • Organizer: 第60回日本新生児成育医学会
  • Place of Presentation: 盛岡
  • Year and Date: 2015-10-23
• [Presentation] ビリルビン誘導蛍光タンパク質（UnaG）を用いた新たな新生児血清中の非抱合型ビリルビン濃度測定法 (2015)
  • Author(s): 岩谷壮太、中村 肇、西田浩輔、藤田香織、山名啓司、黒川大輔、長坂美和子、香田 翼、飯島一誠、森岡一朗
  • Organizer: 第51回日本周産期・新生児医学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-10
• [Presentation] Serum unbound bilirubin and clinical kernicterus in extremely low birth weight infants (2015)
  • Author(s): Morioka I, Nakamura H, Koda T, Sakai H, Kurokawa D, Yonetani M, Morisawa T, Katayama Y, Wada H, Funato M, Takatera A, Okumura A, Iijima K
  • Organizer: 第57回日本小児神経学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-05-28
• [Presentation] A novel measurement method for serum unconjugated bilirubin concentrations using a bilirubin-inducible fluorescent protein. (2015)
  • Author(s): Iwatani S, Nakamura H, Nishida K, Fujita K, Yamana K, Kurokawa D, Nagasaka M, Koda T, Osawa K, Nishimura N, Nishio H, Iijima K, Kumagai A, Miyawaki A, Morioka I
  • Organizer: Pediatric Academic Society Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Presentation] Screening for hyperbilirubinemia using transcutaneous bilirubin measurement in very low birth weight infants. (2015)
  • Author(s): Kurokawa D, Koda T, Nagai M, Yokota T, Morisawa T, Yonetani M, Katayama Y, Sakai H, Ioroi T, Nakamura H, Iijima K, Morioka I
  • Organizer: Pediatric Academic Society Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Presentation] Efficacy of Phototherapy Using Blue Light-Emitting Diodes In Japanese Neonates: A Prospective Nested Case-Control Study. (2015)
  • Author(s): Yamana K, Koda T, Iwatani S, Nagasaka M, Kurokawa D, Fujita K, Nishida K, Kuroe K, Nakamura H, Iijima K, Morioka I.
  • Organizer: the 11th Congress of Asian Society for Pediatric Research
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] 超低出生体重児における経皮ビリルビン濃度の正確性に関する検討 (2014)
  • Author(s): 黒川大輔、香田 翼、永井正志、横田知之、森沢 猛、米谷昌彦、片山義規、坂井仁美、五百蔵智明、飯島一誠、中村 肇、森岡一朗
  • Organizer: 第59回日本未熟児新生児学会
  • Place of Presentation: 松山
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] 我が国の超早産児に対する黄疸管理の現状 (2014)
  • Author(s): 森岡一朗、香田 翼、横田知之、中村 肇、米谷昌彦
  • Organizer: 第50回日本周産期・新生児医学会
  • Place of Presentation: 浦安
  • Year and Date: 2014-07-13 – 2014-07-15
• [Presentation] 早産児の遷延性黄疸に対する治療と核黄疸発生の頻度 (2014)
  • Author(s): 森岡一朗、香田 翼、横田知之、中村 肇
  • Organizer: 第50回日本周産期・新生児医学会
  • Place of Presentation: 浦安
  • Year and Date: 2014-07-13 – 2014-07-15
• [Presentation] Bilirubin/albumin molar ratios at the critical level of serum unbound bilirubin in hyperbilirubinemis neonates. (2014)
  • Author(s): Hajime Nakamura, Tsubasa Koda, Tomoyuki Yokota, Shoichi Tokumoto, Masashi Nagai, Takeshi Morisawa, Masahiko Yonetani, Kazumoto Iijima, Ichiro Morioka.
  • Organizer: Oral talk at the Pediatric Academic Society and Society for Asian Pediatric Research Joint Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Unbound serum bilirubin levels and kerinicterus in Japanese preterm infants less than 30 weeks gestation. (2014)
  • Author(s): Ichiro Morioka, Tsubasa Koda, Hitomi Sakai, Masahiko Yonetani, Takeshi Morisawa, Yoshinori Katayama, Hiroshi Wada, Akihiro Takatera, Akihisa Okumura, Itsuko Sato, Seiji Kawano, Hajime Nakamura, Kazumoto Iijima.
  • Organizer: Pediatric Academic Society and Society for Asian Pediatric Research Joint Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Efficacy of phototherapy devices in decreasing unbound serum bilirubin levels. (2014)
  • Author(s): Takeshi Morisawa, Shoichi Tokumoto, Masashi Nagai, Kotaro Inaguma, Keiji Yamana, Satoru Morikawa, Ichiro Morioka, Masahiko Yonetani, Hajime Nakamura.
  • Organizer: Pediatric Academic Society and Society for Asian Pediatric Research Joint Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] The efficacy of intravenous albumin administration for decresing unbound bilirubin levels. (2014)
  • Author(s): Shoichi Tokumoto, Takeshi Morisawa, Masashi Nagai, Kotaro Inaguma, Keiji Yamana, Satoru Morikawa, Ichiro Morioka, Masahiko Yonetani, Hajime Nakamura.
  • Organizer: Pediatric Academic Society and Society for Asian Pediatric Research Joint Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-05-03 – 2014-05-06
• [Remarks] 神戸大学大学院医学研究科内科系講座小児科学分野ホームページ
  • URL: http://www.med.kobe-u.ac.jp/pediat/
• [Patent(Industrial Property Rights)] 血液試料中のアンバウンドビリルビンの測定方法 (2016)
  • Inventor(s): 岩谷壮太、森岡一朗、中村肇、宮脇敦史、熊谷安希子
  • Industrial Property Rights Holder: 岩谷壮太、森岡一朗、中村肇、宮脇敦史、熊谷安希子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-03-30
  • Overseas
• [Patent(Industrial Property Rights)] 血液試料中のアンバウンドビリルビンの測定方法 (2015)
  • Inventor(s): 岩谷壮太、森岡一朗、中村 肇、宮脇敦史、熊谷安希子
  • Industrial Property Rights Holder: 岩谷壮太、森岡一朗、中村 肇、宮脇敦史、熊谷安希子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-068471
  • Filing Date: 2015-03-30