| Project/Area Number |
26461635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三木 崇範 香川大学, 医学部, 教授 (30274294)
太田 健一 香川大学, 医学部, 助教 (50403720)
割田 克彦 鳥取大学, 農学部, 准教授 (40452669)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脂肪酸 / 発達 / BDNF / 脳 / 肝臓 / 脳由来神経栄養因子 / 脂質 / コレステロール |
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| Outline of Final Research Achievements |
It is suggested that lower dietary intake of nutrients such as fatty acids during the development is related to the vulnerability to the on-set of psychiatric disorders. However, brain fatty acid homeostasis in the neonatal period has not been fully understand. In this study, we tried to elucidate the brain lipid homeostasis in this period. As a result, it was found that saturated fatty acids are actively desaturated in neonatal brain, that BDNF (Brain-derived neurotrophic factor) is involved in liver SCD-1 activity and can participate in systemic fatty acid homeostasis, and that BDNF induces the expression of HPA axis-related protein.
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