| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Low birth weight is strongly predictive of lifestyle related disease. Animal study indicated that fetal malnutrition induce fetuses with growth retardation have a decreased beta cell mass, which persists into adulthood and causes glucose intolerance. However, The verification of this malnutrition’s effect on human fetuses was difficult. The aim of this study is checking the effect of fetal malnutrition on human using human iPS cell pancreatic differentiation methods. In this study, I have found that important amino acids which regulate pancreatic differentiation at narrow time windows using novel pancreatic differentiation methods established in this study. As a results of amino acid deprivation during pancreatic endocrine differentiation, the number of pancreatic beta cell is significantly decreased at final stage. These results indicated that iPS cell differentiation systems is useful tools for analysis of fetal origins of adult disease theory.
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