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Study of ATP-sensitive potassium channel in constriction of ductus arteriosus

Research Project

Project/Area Number 26461648
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

Ishii Tetsuko  東京女子医科大学, 医学部, 講師 (00360157)

Co-Investigator(Kenkyū-buntansha) 羽山 恵美子  東京女子医科大学, 医学部, 非常勤講師 (00349698)
中西 敏雄  東京女子医科大学, 医学部, 特任教授 (90120013)
Co-Investigator(Renkei-kenkyūsha) MOMMA Kazuo  東京女子医科大学, 医学部・循環器小児科, 名誉教授 (80075233)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords動脈管 / KATP channel / ATP感受性Kチャネル / SUR2 / KATPチャネル
Outline of Final Research Achievements

ATP-sensitive potassium channels expressed in vascular smooth muscle cells are mainly composed of Kir6.1 and SUR2 subunits. Expression of Kir6.1 and SUR2 transcripts in ductus arteriosus (DA), main pulmonary artery (PA), and descending aorta (dAo) in rat immature and mature fetuses, and newborns were determined using real-time PCR. Both Kir6.1 and SUR2 transcripts are expressed in the DA higher than PA and dAo in the fetuses and newborns. Unidentified SUR2 transcript variants are expressed in the immature fetal DA, specifically.
Glibenclamide, an inhibitor of ATP-sensitive potassium channel, directly injected intraperitoneally to fetus rats, constricted DA in near-term and preterm. Effect of glibenclamide in the DA was dose-dependently. With clinical dose (1mg/kg), DA diameter was 70%, and with 100mg/kg, DA closed completely. Glibenclamide closes neonatal DA dose-dependently in hypoxia but not following prenatal chronic exposure to indomethacin.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] 動脈管薬の実験40年2016

    • Author(s)
      門間和夫
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 32 Pages: 261-269

    • NAID

      130005256742

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Glibenclomid closes neonatal ductus arteriosus in rats.2014

    • Author(s)
      Momma K, Toyoshima K, Hayama E, Nakanishi T
    • Organizer
      Fifth European Academy of Pediatrics
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-10-17 – 2014-10-21
    • Related Report
      2014 Research-status Report
  • [Presentation] インドメタシン母体投与による未熟児PDAラットモデルにおけるスルホニル尿素薬の動脈管収縮促進作用2014

    • Author(s)
      豊島勝昭,門間和夫, 門間美佳,石井徹子,中西敏雄
    • Organizer
      第8回新生児内分泌研究会
    • Place of Presentation
      京都リサーチパークサイエンスホール
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 動脈管の研究40年2014

    • Author(s)
      門間和夫
    • Organizer
      第50回日本小児循環器学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] Etiology and Morphogenesis of Congenital Heart Disease.2016

    • Author(s)
      Momma K, Monma M, Toyoshima K, Hayama E, Nakanishi T.
    • Publisher
      Springer, Japan.
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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