| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
Mal de Meleda is an autosomal recessive palmoplantar keratosis and shows severe transgradient hyperkeratosis. Recently, the causative gene is demonstrated to be the SLURP1 gene. In this study, analysis of the SLURP1 gene in patients with palmoplantar keratosis tried to detect the gene mutations. We cultured keratinocytes and fibroblasts from the patients and examined gene and protein expressions of the SLURP1 gene. Also, we introduced the expression vector of the SLURP1 cDNA to the patient cells and examined the expressions of the gene related with keratinization. These results show in part the mechanisms of hyperkeratosis seen in the patients.
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