Elucidation of the regulation by secreted protein MFG-E8, and the development of new therapy
| Project/Area Number |
26461654
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 創傷治癒 / 悪性黒色腫 / 強皮症 / 線維化 / 間葉系幹細胞 |
|---|
| Outline of Final Research Achievements |
We studied the role of secreted protein MFG-E8 in wound healing, tumor angiogenesis, fibrosis. Based on the results of this study, we found that MFG-E8 enhances angiogenesis, regulates macrophages, resulting in the acceleration of wound healing, promoting tumor growth, and inhibition of fibrosis. If we can further elucidate the mechanism by which MFG-E8 regulates wound healing, tumor angiogenesis and fibrosis, it will help to understand the pathogenesis of refractory ulcer, malignant tumor, scleroderm, and it can be expected to contribute greatly to the development of new therapy.
|
Report
(4 results)
Research Products
(8 results)
