Analysis of autoimmune responses against DNA mismatch repair enzymes in dermatomyositis
| Project/Area Number |
26461656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
Muro Yoshinao 名古屋大学, 医学系研究科, 准教授 (80270990)
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| Research Collaborator |
MOMOHARA MARIKO
YAMAMOTO ERI
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 皮膚筋炎 / 自己抗体 / DNAミスマッチ修復酵素 / 多発性筋炎 |
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| Outline of Final Research Achievements |
DNA mismatch repair is an important life system, which is conserved from bacteria to human, and starts by mismatch recognition where seven kinds of enzymes are involved in human. We reported that patients with collagen diseases including inflammatory myopathy carry autoantibodies against four kinds of these enzymes. Further studies clarified that major targets of these antibodies are MLH1 and PMS1 and that some patients who had these antibodies also simultaneously carried other myositis-marker autoantibodies and other patients did not. We have found that commercially available substrates for indirect immunofluorescence tests were not suitable for the screening of autoantibodies against these enzymes and the suitable fixed cultured cells for the screening. Moreover, we have found the possibility that ultraviolet irradiation to cultured keratinocytes might influence the expression of these enzymes (autoantigens).
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Report
(5 results)
Research Products
(76 results)
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[Journal Article] HMGCR antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma.2016
Author(s)
Tsujikawa K, Hara K, Muro Y, Nakanishi H, Niwa Y, Koike M, Noda S, Riku Y, Sahashi K, Atsuta N, Ito M, Shimoyama Y, Akiyama M, Katsuno M.
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Journal Title
Neurology
Volume: 87
Issue: 8
Pages: 841-843
DOI
Related Report
Peer Reviewed
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[Journal Article] Antisynthetase syndrome: Pulmonary computed tomography findings of adult patients with antibodies to aminoacyl-tRNA synthetases.2016
Author(s)
Waseda Y, Johkoh T, Egashira R, Sumikawa H, Saeki K, Watanabe S, Matsunuma R, Takato H, Ichikawa Y, Hamaguchi Y, Shiraki A, Muro Y, Yasui M, Prosch H, Herold C, Kasahara K.
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Journal Title
Eur J Radiol.
Volume: 85
Issue: 8
Pages: 1421-1426
DOI
Related Report
Peer Reviewed
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[Journal Article] Diversity of humoral responses to the centromere proteins among HCV-related chronic liver disease, PBC and AIH patients.2015
Author(s)
Himoto T, Tanaka N, Saito A, Muro Y, Sugiura K, Tani J, Miyoshi H, Morishita A, Yoneyama H, Haba R, Masaki T.
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Journal Title
Clin Res Hepatol Gastroenterol
Volume: 39
Issue: 2
Pages: 222-229
DOI
Related Report
Peer Reviewed
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[Journal Article] 皮膚筋炎2015
Author(s)
村瀬千晶、室 慶直、秋山真志
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Journal Title
Visual Dermatology
Volume: 15
Pages: 66-67
NAID
Related Report
Peer Reviewed
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[Presentation] 食道扁平上皮癌を合併した抗HMGCR抗体関連ミオパチーの治療経験2016
Author(s)
辻河 高陽, 原 一洋, 室 慶直, 中西 浩隆, 丹羽 由紀子, 小池 聖彦, 野田 成哉, 陸 雄一, 佐橋 健太郎, 熱田 直樹, 伊藤 瑞規, 下山 芳江, 秋山 真志, 勝野 雅央
Organizer
第34回日本神経治療学会総会
Place of Presentation
米子コンベンションセンター（鳥取県米子市）
Year and Date
2016-11-05
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