| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Photoaging was induced using long-term ultraviolet (UV)A eye irradiation for 12 months. UVA eye irradiation increases the production of reactive oxygen species (ROS) from gp91phox in the brain, and this gp91phox-induced ROS stimulates urocortin 2. Moreover, urocortin 2 increases the degranulation of tryptase and histamine from mast cells of the skin, thereby leading to photoaging. On the other hand, our data suggested that long-term UVA eye irradiation results in depression of the memory and learning ability. The alteration similar to Alzheimer's disease occurs to the protein in the brain, and the introduction of glucose into the brain is additionally decreased. In addition, it was suggested that there is a close relation to photo aging, and memory and learning ability depression through a CRH/POMC system.
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