| Project/Area Number |
26461668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Research Collaborator |
IMAI YASUTOMO 兵庫医科大学, 医学部, 講師 (10529514)
YAMAMOTO MASAAKI 兵庫医科大学, 医学部, 助手 (60624640)
HANEDA TAKASHI 兵庫医科大学, 医学部, 助教 (90580035)
NAGAI MAKOTO 兵庫医科大学, 医学部, 助教 (30791545)
SAKAGUCHI YOSHIKO 兵庫医科大学, 医学部, 実験補助
JITSUKAWA ORIE 兵庫医科大学, 医学部, 実験補助
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 角化症 / 自然免疫 / トランスグルタミナーゼ / サイトカイン / 抗菌ペプチド / IL-33 / 魚鱗癬 / 掌蹠角化症 / 遺伝子変異 / アトピー性皮膚炎 |
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| Outline of Final Research Achievements |
When skin is injured by internal or external insults, alarmins, such as interleukin 33 (IL-33), is released from keratinocytes and inflammatory and repairing reactions are induced. In the present study, analysis of mutations in 40 cases with keratinization disorders and the expression of alarmins were examined in the skin. The up-regulation of IL-33 in the epidermis of Netherton syndrome was observed, and the induction of genes involved in innate immune responses, such as antimicrobial peptides, was found in the skin with transglutaminase 1 deficiency. From these results, we proposed the autonomous regulation of molecular signatures for innate immune responses in the pathogenesis of keratinization disorders.
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