| Project/Area Number |
26461686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
OKUYAMA Ryuhei 信州大学, 学術研究院医学系, 教授 (80292332)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Eisaku 信州大学, 学術研究院医学系, 助教 (20451586)
SAITO Rumiko 東北大学, 東北メディカルメガバンク, 非常勤講師 (40451588)
UCHIYAMA Ryuhei 信州大学, 医学部附属病院, 助教(特定雇用) (00447757)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Notch / 再生表皮 / 皮膚潰瘍 / IL-36 / 表皮 / 再生 / 潰瘍 |
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| Outline of Final Research Achievements |
Skin ulcer is a common disease, and leads to drastic decrease in the quality of life. In order to improve the treatment of skin ulcers, we focused on Notch, a signaling molecule, because the expression of Notch decreases in regenerating epidermis around skin ulcer. Our analysis showed that Notch down-regulation suppresses keratinocyte differentiation which promotes the cellular plasticity. Furthermore, Notch down-regulation induces IL-36, a member of IL-1, suggesting the increase of the resistance to exogenous pathogenic microorganisms.
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