Analysis of Notch signal pathway in epidermal regeneration and its application to therapy
Project/Area Number |
26461686
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Shinshu University |
Principal Investigator |
OKUYAMA Ryuhei 信州大学, 学術研究院医学系, 教授 (80292332)
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Co-Investigator(Renkei-kenkyūsha) |
OGAWA Eisaku 信州大学, 学術研究院医学系, 助教 (20451586)
SAITO Rumiko 東北大学, 東北メディカルメガバンク, 非常勤講師 (40451588)
UCHIYAMA Ryuhei 信州大学, 医学部附属病院, 助教(特定雇用) (00447757)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | Notch / 再生表皮 / 皮膚潰瘍 / IL-36 / 表皮 / 再生 / 潰瘍 |
Outline of Final Research Achievements |
Skin ulcer is a common disease, and leads to drastic decrease in the quality of life. In order to improve the treatment of skin ulcers, we focused on Notch, a signaling molecule, because the expression of Notch decreases in regenerating epidermis around skin ulcer. Our analysis showed that Notch down-regulation suppresses keratinocyte differentiation which promotes the cellular plasticity. Furthermore, Notch down-regulation induces IL-36, a member of IL-1, suggesting the increase of the resistance to exogenous pathogenic microorganisms.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.2017
Author(s)
Hidaka, T., Ogawa, E., Kobayashi, E.H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., Yamamoto, M.
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Journal Title
Nat. Immunol.
Volume: 18
Issue: 1
Pages: 64-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Intratumoral expression levels of PD-L1, GZMA, and HLA-A associated with oligoclonal T cell expansion predict response to nivolumab in metastatic melanoma2016
Author(s)
Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Fish collagen is an important panallergen in the Japanese population2016
Author(s)
Kobayashi Y, Akiyama H, Huge J, Kubota H, Chikazawa S, Satoh T, Miyake T, Uhara H, Okuyama R, Nakagawara R, Aihara M, Hamada-Sato N
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Journal Title
Allergy
Volume: 未定
Issue: 5
Pages: 720-723
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients.2015
Author(s)
Sakaizawa K, Ashida A, Uchiyama A, Ito T, Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S, Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama R, Yamazaki N, Uhara H.
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Journal Title
J Dermatol Sci.
Volume: 80
Issue: 1
Pages: 33-37
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma.2015
Author(s)
Yamazaki N, Kiyohara Y, Uhara H, Fukushima S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S, Okuyama R, Ito Y, Tokudome T.
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Journal Title
Cancer Chemother Pharmacol.
Volume: 76
Issue: 5
Pages: 994-1004
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma2015
Author(s)
Yamazaki N, Uhara H, Fukushima S, Uchi H, Shibagaki N, Kiyohara Y, Tsutsumida A, Namikawa K, Okuyama R, Otuska Y, Tokudome T
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Journal Title
Cancer Chemoth Pharm
Volume: 76
Issue: 5
Pages: 969-975
DOI
Related Report
Peer Reviewed
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[Presentation] Comparative study of cutaneous adverse reactions induced by a proteasome inhibitor with skin eruptions in Nakajo-Nishimura syndrome2016
Author(s)
Kunimoto K, Kanazawa N, Furukawa F, Manabe K, Asagoe K, Yamasaki O, Kabahara T, Kanaoka M, Aihara M, Terasaki Y, Izaki S, Okuyama R, Yamamoto T, Hanna J
Organizer
The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
Place of Presentation
Sendai International Center, Sendai
Year and Date
2016-12-09
Related Report
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[Presentation] Phase 2 Study of Ipilimumab in Japanese Patients with Advanced Melanoma2015
Author(s)
Uhara H, Kiyohara Y, Fukushima S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S, Okuyama R, Ito Y, Otsuka Y, Tokudome T, Yamazaki N
Organizer
American Academy of Dermatology Summer Meeting
Place of Presentation
New York (USA)
Year and Date
2015-08-19
Related Report
Int'l Joint Research
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