Analysis of Notch signal pathway in epidermal regeneration and its application to therapy

• Project/Area Number: 26461686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Shinshu University
• Principal Investigator: OKUYAMA Ryuhei 信州大学, 学術研究院医学系, 教授 (80292332)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Eisaku 信州大学, 学術研究院医学系, 助教 (20451586) ; SAITO Rumiko 東北大学, 東北メディカルメガバンク, 非常勤講師 (40451588) ; UCHIYAMA Ryuhei 信州大学, 医学部附属病院, 助教(特定雇用) (00447757)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Notch / 再生表皮 / 皮膚潰瘍 / IL-36 / 表皮 / 再生 / 潰瘍

Outline of Final Research Achievements

Skin ulcer is a common disease, and leads to drastic decrease in the quality of life. In order to improve the treatment of skin ulcers, we focused on Notch, a signaling molecule, because the expression of Notch decreases in regenerating epidermis around skin ulcer. Our analysis showed that Notch down-regulation suppresses keratinocyte differentiation which promotes the cellular plasticity. Furthermore, Notch down-regulation induces IL-36, a member of IL-1, suggesting the increase of the resistance to exogenous pathogenic microorganisms.

Research Products

• [Journal Article] Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells (2017)
  • Author(s): Sato Y, Kato H, Ebina-Shibuya R, Itoh-Nakadai A, Okuyama R, Igarashi K
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 241 Issue: 3 Pages: 175-182
  • DOI: 10.1620/tjem.241.175
  • NAID: 130005241504
  • Peer Reviewed / Open Access
• [Journal Article] AhR links atopic dermatitis and air pollution 1 via Artemin induction. (2017)
  • Author(s): Hidaka, T., Ogawa, E., Kobayashi, E.H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., Yamamoto, M.
  • Journal Title: Nature Immunology Volume: 18 Pages: 64-73
  • DOI: 10.1038/ni.3614
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Detection of BRAFV600K mutant tumor-derived DNA in the pleural effusion from a patient with metastatic melanoma. (2017)
  • Author(s): Sakaizawa K, Ashida A, Uhara H, Okuyama R.
  • Journal Title: Clinical Chemistry and Laboratory Medicine (CCLM) Volume: 55 Pages: 92-95
  • DOI: 10.1515/cclm-2016-0634
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intratumoral expression levels of PD-L1, GZMA, and HLA-A associated with oligoclonal T cell expansion predict response to nivolumab in metastatic melanoma (2016)
  • Author(s): Inoue H, Park JH, Kiyotani K, Zewde M, Miyashita A, Jinnin M, Kiniwa Y, Okuyama R, Tanaka R, Fujisawa Y, Kato H, Morita A, Asai J, Katoh N, Yokota K, Akiyama M, Ihn H, Fukushima S, Nakamura Y
  • Journal Title: Oncoimmunology Volume: 5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel role of ASC as a regulator of metastatic phenotype (2016)
  • Author(s): Okada N1, Fujii C1,2, Matsumura T, Kitazawa M, Okuyama R, Taniguchi S, and Hida S (1: Contributed equally, 2: Corresponding author)
  • Journal Title: Cancer Med. Volume: 5 Pages: 2487-2500
  • DOI: 10.1002/cam4.800
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunotherapy for advanced melanoma: Current knowledge and future directions (2016)
  • Author(s): Nakamura K, Okuyama R
  • Journal Title: J Dermatol Sci Volume: 83 Pages: 87-94
  • DOI: 10.1016/j.jdermsci.2016.05.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Quantitative analysis of the BRAFV600E mutation in circulating tumor-derived DNA using competitive allele-specific TaqMan PCR in melanoma patients (2016)
  • Author(s): Ashida A, Sakaizawa K, Mikoshiba A, Uhara H, Okuyama R
  • Journal Title: Int J Clin Oncol. Volume: 21 Pages: 981-988
  • DOI: 10.1007/s10147-016-0976-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fish collagen is an important panallergen in the Japanese population (2016)
  • Author(s): Kobayashi Y, Akiyama H, Huge J, Kubota H, Chikazawa S, Satoh T, Miyake T, Uhara H, Okuyama R, Nakagawara R, Aihara M, Hamada-Sato N
  • Journal Title: Allergy Volume: 未定 Pages: 720-723
  • DOI: 10.1111/all.12836
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inhibition of Epidermal Growth Factor Receptor Induces Tumor Necrosis Factor-α via Activation of Peroxisome Proliferator-Activated Receptor-γ and Nuclear Factor-κB in Sebocytes: A Possible Pathogenesis of Papulopustular Rash (2016)
  • Author(s): Atsuko Ashida, Akira Shimizu, Ryuhei Okuyama
  • Journal Title: J Dermatol Sci Volume: 印刷中 Pages: 53-56
  • DOI: 10.1111/1346-8138.13262
  • Peer Reviewed / Open Access
• [Journal Article] Melanomas favor mechanical stress points on the plantar surface (2016)
  • Author(s): Minagawa A, Omodaka T, Okuyama R
  • Journal Title: N Engl J Med Volume: 374 Pages: 2404-2406
  • DOI: 10.1056/nejmc1512354
  • Peer Reviewed / Open Access
• [Journal Article] 5-Hydroxymethylcytosine as a putative marker for erosive adenomatosis of the nipple (2016)
  • Author(s): Takazawa Y, Edamitsu T, Maeno K, Ogawa E, Uhara H, Kawachi S, Ito K, Okuyama R
  • Journal Title: J Dermatol Volume: 374 Pages: 579-580
  • DOI: 10.1111/1346-8138.13237
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Melanocytic naevus shows parallel ridge pattern due to the melanin columns under the surface ridge (2015)
  • Author(s): Sano T, Minigawa A, Koga H, Uhara H, Okuyama R
  • Journal Title: Acta Derm Venereol Volume: 95 Pages: 95-96
  • DOI: 10.2340/00015555-1865
  • Peer Reviewed / Open Access
• [Journal Article] Pigmented macule on the nipple (2015)
  • Author(s): Asai Y, Minagawa A, Koga H, Okuyama R
  • Journal Title: Clin Exp Dermatol Volume: 40 Pages: 938-940
  • DOI: 10.1111/ced.12647
  • Peer Reviewed
• [Journal Article] An immunogenetic study of bullous pemphigoid with mucosal involvement in two siblings (2015)
  • Author(s): Minagawa A, Arakura F, Koga H, Tokuda Y, Koga H, Hashimoto T, Okuyama R
  • Journal Title: Eur J Dermatol Volume: 25 Pages: 186-188
  • DOI: 10.1684/ejd.2014.2494
  • Peer Reviewed
• [Journal Article] Brown nodule on the lower eyelid (2015)
  • Author(s): Shirota S, Minagawa A, Koga H, Momose M, Uhara H, Okuyama R
  • Journal Title: Acta Derm Venereol Volume: 95 Pages: 1037-1039
  • DOI: 10.2340/00015555-2124
  • Peer Reviewed / Open Access
• [Journal Article] A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (<i>Oca2^p</i>) in mice (2015)
  • Author(s): Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M
  • Journal Title: Exp. Anim. Volume: 64 Issue: 2 Pages: 171-179
  • DOI: 10.1538/expanim.14-0075
  • NAID: 130005069859
  • Peer Reviewed
• [Journal Article] Notch down-regulation in regenerated epidermis contributes to enhanced expression of interleukin-36α and suppression of keratinocyte differentiation during wound healing (2015)
  • Author(s): Takazawa Y, Ogawa E, Saito R, Uchiyama R, Ikawa S, Uhara H, Okuyama R
  • Journal Title: J Dermatol Sci Volume: 79 Pages: 10-19
  • DOI: 10.1016/j.jdermsci.2015.04.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Primarycutaneous nocardiosis caused by Nocardia concave (2015)
  • Author(s): Nakamura K, Kamijo F, Negishi T, Matsumoto T, Okuyama R, Uhara H
  • Journal Title: J Dermatol Volume: 42 Pages: 1121-1122
  • DOI: 10.1111/1346-8138.13036
  • Peer Reviewed
• [Journal Article] Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melanoma patients (2015)
  • Author(s): Sakaizawa K, Ashida A, Uchiyama A, Ito T, Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S, Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama R, Yamazaki N, Uhara H.
  • Journal Title: Jounal of Dermatological Science Volume: 80 Pages: 33-37
  • DOI: 10.1016/j.jdermsci.2015.07.012
  • Peer Reviewed / Open Access
• [Journal Article] Histopathological improvement of scleroderma induced by paclitaxel in a patient with breast cancer (2015)
  • Author(s): Ohashi A, Minagawa A, Ashida A, Koga H, Uhara H, Okuyama R
  • Journal Title: J Dermatol Volume: 42 Pages: 1198-1199
  • DOI: 10.1111/1346-8138.13085
  • Peer Reviewed / Open Access
• [Journal Article] Phase II study of ipilimumab monotherapy in Japanese patients with advanced melanoma (2015)
  • Author(s): Yamazaki N, Kiyohara Y, Uhara H, Fukushima S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S, Okuyama R, Ito Y, Tokudome T.
  • Journal Title: Cancer Chemoth Pharm Volume: 76 Pages: 994-1004
  • DOI: 10.1007/s00280-015-2873-x
  • Peer Reviewed / Open Access
• [Journal Article] Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma (2015)
  • Author(s): Yamazaki N, Uhara H, Fukushima S, Uchi H, Shibagaki N, Kiyohara Y, Tsutsumida A, Namikawa K, Okuyama R, Otuska Y, Tokudome T
  • Journal Title: Cancer Chemoth Pharm Volume: 76 Pages: 969-975
  • DOI: 10.1007/s00280-015-2870-0
  • Peer Reviewed
• [Journal Article] 信州大学における悪性黒色腫245例 (2015)
  • Author(s): 中村謙太、皆川茜、芦田敦子、古賀弘志、木庭幸子、奥山隆平、宇原久
  • Journal Title: 日本皮膚科学会誌 Volume: 125 Pages: 1587-1592
  • Peer Reviewed
• [Journal Article] 顆粒細胞腫のダーモスコピー像の1例 (2015)
  • Author(s): 中村謙太、河内繁雄、古賀弘志、宇原久、奥山隆平
  • Journal Title: 皮膚科の臨床 Volume: 57 Pages: 1488-1489
  • Peer Reviewed
• [Journal Article] Hair diameter versus hair density in male androgenetic alopecia (2014)
  • Author(s): Okuyama R
  • Journal Title: Br J Dermatol Volume: 171 Pages: 931-931
  • DOI: 10.1111/bjd.13390
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 signaling promotes the migration of human melanoma cells (2014)
  • Author(s): Takazawa Y, Kiniwa Y, Ogawa E, Uchiyama A, Ashida A, Uhara H, Goto Y, Okuyama R
  • Journal Title: Tohoku J Exp Med Volume: 234 Pages: 57-65
  • NAID: 130004685014
  • Peer Reviewed
• [Journal Article] Varicella zoster virus-induced generalized pustular psoriasis in a baby with heterozygous IL36RN mutation (2014)
  • Author(s): Sugiura K, Uchiyama R, Okuyama R, Akiyama M
  • Journal Title: J Am Acad Dermatol Volume: 71
  • DOI: 10.1016/j.jaad.2014.07.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Histopathological correlation to the dermoscopic feature of “string of pearls” in clear cell acanthoma (2014)
  • Author(s): Miyake T, Minagawa A, Koga H, Fukuzawa M, Okuyama R
  • Journal Title: Eur J Dermatol Volume: 24 Pages: 498-499
  • DOI: 10.1684/ejd.2014.2422
  • Peer Reviewed
• [Journal Article] Coexpression of EpCAM, CD44 variant isoforms and claudin-7 in anaplastic thyroid carcinoma. (2014)
  • Author(s): Okada T, Nakamura T, Watanabe T, Onoda N, Asida A, Okuyama R, Ito K
  • Journal Title: PLoS One Volume: 9 Pages: 1-13
  • DOI: 10.1371/journal.pone.0094487
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Case of Kindler Syndrome with Severe Esophageal Stenosis (2014)
  • Author(s): Ohashi A, Kiniwa Y, Kosho T, Suga T, Has C, Kubo H, Okuyama R
  • Journal Title: Int J Dermatol Volume: 54
  • DOI: 10.1111/ijd.12715
  • Peer Reviewed
• [Journal Article] Detection of the tumor margin of Basal-cell carcinoma using dermoscopy and high-frequency ultrasound with narrow pieces of surgical tape as skin markers (2014)
  • Author(s): Hayashi K, Uhara H, Okuyama R
  • Journal Title: Dermatol Surg Volume: 40 Pages: 704-706
  • Peer Reviewed
• [Journal Article] IgA/IgG pemphigus with infiltration of neutrophils and eosinophils in an ulcerative colitis patient (2014)
  • Author(s): Asai Y, Kiniwa Y, Okada N, Futatsugi T, Ushiki A, Uhara H, Okuyama R
  • Journal Title: Acta Derm Venereol Volume: 24 Pages: 402-403
  • DOI: 10.2340/00015555-1836
  • Peer Reviewed / Open Access
• [Journal Article] Marked histiocytic infiltration in neonatal lupus erythematosus (2014)
  • Author(s): Okada N, Okuyama R, Uhara H
  • Journal Title: J Dermatol Volume: 41 Pages: 192-193
  • DOI: 10.1111/1346-8138.12381
  • Peer Reviewed
• [Journal Article] Usefulness of high-frequency sonography for the diagnosis of asymptomatic myopathy in Lofgren’s syndrome (2014)
  • Author(s): Ohashi A, Koga H, Hayashi K, Uhara H, Okuyama R
  • Journal Title: Int J Dermatol Volume: 53
  • DOI: 10.1111/j.1365-4632.2012.05489.x
  • Peer Reviewed
• [Journal Article] Generalised acanthosis nigricans in childhood with short stature associated with poor response to growth hormone provocation. (2014)
  • Author(s): Iwade M, Ogawa E, Koga H, Mizuno F, Koike K, Matsumoto K, Okuyama R
  • Journal Title: Acta Derm Venereol. Volume: 94 Pages: 486-487
  • DOI: 10.2340/00015555-1759
  • Peer Reviewed / Open Access
• [Journal Article] 5-Hydroxymethylcytosine as a useful marker to differentiate between malignant melanomas and benign melanocytic nevi. (2014)
  • Author(s): Uchiyama R, Uhar H, Uchiyama A, Ogawa E, Takazawa Y, Ashida A, Koga H, Hayashi K, Kiniwa Y, Okuyama R
  • Journal Title: J Dermatol Sci. Volume: 73 Pages: 161-163
  • DOI: 10.1016/j.jdermsci.2013.09.008
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of dermoscopic features in a juvenile xanthogranuloma during follow-up of 43 months (2014)
  • Author(s): Unno T, Minagawa A, Koga H, Uhara H, Okuyama R
  • Journal Title: Int J Dermatol Volume: 53
  • DOI: 10.1111/ijd.12530
  • Peer Reviewed
• [Journal Article] Vascular structures absence under dermoscopy in two cases of Angiosarcoma on the scalp (2014)
  • Author(s): Minagawa A, Koga H, Okuyama R
  • Journal Title: Int J Dermatol Volume: 53
  • DOI: 10.1111/ijd.12357
  • Peer Reviewed
• [Journal Article] NRAS mutations in primary and metastatic melanomas of Japanese patients (2014)
  • Author(s): Uhara H, Ashida A, Koga H, Uchiyama A, Uchiyama R, Hayashi K, Kiniwa Y, Okuyama R
  • Journal Title: International J of Oncology Volume: - Pages: 544-548
  • DOI: 10.1007/s10147-013-0573-2
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Comparative study of cutaneous adverse reactions induced by a proteasome inhibitor with skin eruptions in Nakajo-Nishimura syndrome (2016)
  • Author(s): Kunimoto K, Kanazawa N, Furukawa F, Manabe K, Asagoe K, Yamasaki O, Kabahara T, Kanaoka M, Aihara M, Terasaki Y, Izaki S, Okuyama R, Yamamoto T, Hanna J
  • Organizer: The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Sendai International Center, Sendai
  • Year and Date: 2016-12-09
• [Presentation] Novel role of ASC as a regulator of metastatic phenotype (2016)
  • Author(s): Okada N, Fujii C, Matsumura T, Kitazawa M, Tanigushi S, Hida S, Uhara H, Okuyama R
  • Organizer: The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Sendai International Center, Sendai
  • Year and Date: 2016-12-09
• [Presentation] Defieciency of Bach2 results in improved tumor immunity by enhancing effector function in CD8+ T cells (2016)
  • Author(s): Sato Y, Watanabe-Matsui M, Sharda DR, Igarashi K, Okuyama R.
  • Organizer: The 41th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Sendai International Center, Sendai
  • Year and Date: 2016-12-09
• [Presentation] Evaluation of response to nivolumab treatment in patients with metastatic melanoma using circulating tumor DNA (2016)
  • Author(s): 芦田敦子、境澤香里、宇原久、奥山隆平
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-06
• [Presentation] Combination of a BRAF inhibitor and a Toll-like receptor 7 agonist shows synergistic anti-tumor effects (2016)
  • Author(s): 中村謙太、谷口智憲、ポピバノバ ボリアナ、村田眞志、太田陽介、御子柴飛鳥、木庭幸子、奥山隆平、河上裕
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜、パシフィコ横浜
  • Year and Date: 2016-10-06
• [Presentation] 本邦における乾癬性関節炎患者の疫学調査 (2015)
  • Author(s): 山本俊幸、大槻マミ太郎、佐野栄紀、五十嵐敦之、森田明理、奥山隆平、川田暁
  • Organizer: 日本乾癬学会
  • Place of Presentation: ウェスティンナゴヤキャッスル（愛知県名古屋市）
  • Year and Date: 2015-09-04
• [Presentation] 尋常性乾癬と膿疱性乾癬の家族内発症の３例 (2015)
  • Author(s): 小林彩、小川英作、奥山隆平、杉浦一充、秋山真志
  • Organizer: 日本乾癬学会
  • Place of Presentation: ウェスティンナゴヤキャッスル（愛知県名古屋市）
  • Year and Date: 2015-09-04
• [Presentation] エタネルセプトで治療した乾癬性関節炎の１例 (2015)
  • Author(s): 小川英作、小林彩、奥山隆平
  • Organizer: 日本乾癬学会
  • Place of Presentation: ウェスティンナゴヤキャッスル（愛知県名古屋市）
  • Year and Date: 2015-09-04
• [Presentation] Phase 2 Study of Ipilimumab in Japanese Patients with Advanced Melanoma (2015)
  • Author(s): Uhara H, Kiyohara Y, Fukushima S, Uchi H, Shibagaki N, Tsutsumida A, Yoshikawa S, Okuyama R, Ito Y, Otsuka Y, Tokudome T, Yamazaki N
  • Organizer: American Academy of Dermatology Summer Meeting
  • Place of Presentation: New York (USA)
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] 進行期悪性黒色腫患者におけるipilimumabのDTIC併用国内第2相臨床試験 (2015)
  • Author(s): 宇原久、山崎直也、清原祥夫、内博史、福島聡、柴垣直孝、堤田新、奥山隆平、吉川周佐、並川健二郎、徳留拓人
  • Organizer: 日本皮膚悪性腫瘍学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-07-03
• [Presentation] 化学療法未治療進行期悪性黒色腫患者におけるipilimumabの２つの国内第2相臨床試験における安全性マネージメント (2015)
  • Author(s): 内博史、宇原久、福島聡、柴垣直孝、清原祥夫、堤田新、奥山隆平、並川健二郎、大塚康司、山崎直也
  • Organizer: 日本皮膚悪性腫瘍学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-07-03
• [Presentation] 進行期悪性黒色腫患者におけるipilimumab単独療法第2相臨床試験 (2015)
  • Author(s): 福島聡、清原祥夫、宇原久、内博史、柴垣直孝、堤田新、吉川周佐、奥山隆平、伊藤嘉紀、山崎直也
  • Organizer: 日本皮膚悪性腫瘍学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-07-03
• [Presentation] メラノーマ：癌遺伝子 vs 癌抑制遺伝子 (2015)
  • Author(s): 奥山隆平
  • Organizer: 日本皮膚悪性腫瘍学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-07-03
  • Invited
• [Presentation] 日本人の悪性黒色腫のBRAF、NRAS、KIT変異率と臨床所見 (2015)
  • Author(s): 境澤香里、芦田敦子、伊東孝通、藤澤康弘、緒方大、松下茂人、藤井一恭、福島聡、柴山慶継、八田尚人、竹之内辰也、上原治朗、奥山隆平、山﨑直也、宇原久
  • Organizer: 日本皮膚科学会総会
  • Place of Presentation: パジフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-30
• [Presentation] 皮膚癌の術後出血が診断の契機となった後天性13因子欠乏症の１例 (2015)
  • Author(s): 三宅知美、芦田敦子、宇原久、奥山隆平、福澤正男、一瀬白帝
  • Organizer: 日本皮膚科学会総会
  • Place of Presentation: パジフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-30
• [Presentation] クリオフィルトレーションが有効であったクリオグロブリン血症性血管炎による下腿潰瘍の１例 (2015)
  • Author(s): 小林彩、佐野佑、御子柴育朋、内山龍平、古賀弘志、奥山隆平、杉山舞、上條裕司
  • Organizer: 日本皮膚科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-05-30
• [Presentation] Activation of Toll-like receptor 4 induces proliferation and migration of human melanoma cells (2014)
  • Author(s): Ogawa E, Takazawa Y, Kiniwa Y, Uchiyama A, Ashida A, Uhara H, Goto Y, Okuyama R
  • Organizer: Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Osaka, Hotel Hankyu Expopark
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Complication of keratinocyte regulation in psoriasis (2014)
  • Author(s): Okuyama R
  • Organizer: Annual Meeting of the Korean Society for Psoriasis
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-09-13
  • Invited