Role of SLAM in the pathogenesis of atopic dermatitis and IgE induction

Research Project

Project/Area Number	26461691
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Dermatology
Research Institution	Kyoto University
Principal Investigator	KITOH AKIHIKO 京都大学, 医学研究科, 講師 (40508438)
Co-Investigator(Renkei-kenkyūsha)	NOMURA Takashi 京都大学, 医学研究科, 特定講師 (60346054)
Research Collaborator	SHIBUYA Rintaro HANAKAWA Sho
Project Period (FY)	2014-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	IgE / SLAM / アトピー性皮膚炎
Outline of Final Research Achievements	The costimulatory molecule SLAM (CD150) is thought to be important for Th2 type immune reactions. However, the precise role of SLAM in chronic skin inflammation and IgE induction in atopic dermatitis, a typical Th2-related skin disease, is still unclear. Results of this study indicate that SLAM on T lymphocytes is involved in the IgE production associated with atopic dermatitis although SLAM plays only a minimal, if any, role in the development of atopic dermatitis.