Correlation analysis between expression level of vascular growth factors and clinical prognosis in malignant melanoma in multicenter collaboration.
| Project/Area Number |
26461697
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
Kariya Yoshiyuki 琉球大学, 医学(系)研究科(研究院), 助教 (70431559)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
上里 博 琉球大学, 医学(系)研究科(研究院), 名誉教授 (10137721)
高橋 健造 琉球大学, 医学(系)研究科(研究院), 教授 (80291425)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 悪性黒色腫 / 皮膚腫瘍 / 血行転移 / リンパ行転移 / 脈管増殖因子 / 予後 / 血管増殖因子 |
|---|
| Outline of Final Research Achievements |
We investigated the expression level of several vascular growth factors in melanoma tumor tissue samples by immunohistochemistry and statistically analyzed the correlation between the expression level and clinical factors including prognosis and distant metastasis. We discovered strong correlation between HGF(Hepatocyte growth factor) expression and the rate of distant metastasis. The primary tumor samples from patients with metastatic melanoma showed lower expression level of HGF. HGF has been reported to be associated with tumor invasion and metastasis in other type of cancers. Our investigation suggested that HGF play important role in melanoma tumor metastasis and can be a good candidate for prognosis-predicting factor or therapeutic target molecule.
|
Report
(4 results)
Research Products
(41 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Conspicuous Bilateral Eyelids Swelling Appeared in a Patient with Subcutaneous Panniculitis-like T-cell Lymphoma2015
Author(s)
林 健太郎, 宮城 拓也, 園崎 哲, 山口 さやか, 山本 雄一, 高橋 健造, 西 由希子, 仲地 佐和子, 友寄 毅昭, 益崎 裕章, 上里 博
-
Journal Title
Nishi Nihon Hifuka
Volume: 77
Issue: 5
Pages: 487-491
DOI
NAID
ISSN
0386-9784, 1880-4047
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
[Journal Article] 先天性Bednar腫瘍の1例2015
Author(s)
林 健太郎, 仲村 郁心, 眞鳥 繁隆, 粟澤 剛, 山本 雄一, 苅谷 嘉之, 高橋 健造, 上里 博
-
Journal Title
日本小児皮膚科学会雑誌
Volume: 57
Pages: 480-481
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
[Journal Article] Ayadaulin, a novel RGD peptide with dual antihemostatic activities from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis2015
Author(s)
Kato, H., Gomez, E.L., Fujita, M., Ishimaru, Y., Uezato, H., Mimori, T., Iwata, H., Hashiguchi, Y.
-
Journal Title
Biochimie
Volume: 112
Pages: 49-56
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency.2015
Author(s)
Motoki Y, Mizushima S, Taguri M, Takahashi K, Asano R, Kato H, Asai-Sato M, Katayama K, Okamoto N, Hirahara F, Miyagi E.
-
Journal Title
Clin Immunol
Volume: 39
Pages: 700-706
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Genetic divergence in populations of Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis in Ecuador and Peru2014
Author(s)
Kato, H., Caceres, A.G., Gomez, E.A.L., Mimori, T., Uezato, H., Hashiguchi, Y.
-
Journal Title
Acta Tropica
Volume: 141
Pages: 79-87
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] A Case of Giant Subcutaneous Dermoid Cyst of the Right Shoulder2014
Author(s)
片野 あずさ, 内海 大介, 大平 葵, 粕谷 百合子, 苅谷 嘉之, 崎枝 薫, 眞鳥 繁隆, 平良 清人, 高橋 健造, 上里 博
-
Journal Title
Nishi Nihon Hifuka
Volume: 76
Issue: 5
Pages: 469-472
DOI
NAID
ISSN
0386-9784, 1880-4047
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
