Correlation analysis between expression level of vascular growth factors and clinical prognosis in malignant melanoma in multicenter collaboration.

• Project/Area Number: 26461697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: University of the Ryukyus
• Principal Investigator: Kariya Yoshiyuki 琉球大学, 医学(系)研究科(研究院), 助教 (70431559)
• Co-Investigator(Kenkyū-buntansha): 上里 博 琉球大学, 医学(系)研究科(研究院), 名誉教授 (10137721) ; 高橋 健造 琉球大学, 医学(系)研究科(研究院), 教授 (80291425)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 悪性黒色腫 / 皮膚腫瘍 / 血行転移 / リンパ行転移 / 脈管増殖因子 / 予後 / 血管増殖因子

Outline of Final Research Achievements

We investigated the expression level of several vascular growth factors in melanoma tumor tissue samples by immunohistochemistry and statistically analyzed the correlation between the expression level and clinical factors including prognosis and distant metastasis. We discovered strong correlation between HGF(Hepatocyte growth factor) expression and the rate of distant metastasis. The primary tumor samples from patients with metastatic melanoma showed lower expression level of HGF. HGF has been reported to be associated with tumor invasion and metastasis in other type of cancers. Our investigation suggested that HGF play important role in melanoma tumor metastasis and can be a good candidate for prognosis-predicting factor or therapeutic target molecule.

Research Products

• [Journal Article] Dermoscopic observation of acquired digital fibrokeratoma developed on the dorsum of the fourth left toe. (2016)
  • Author(s): Hayashi K, Matori S, Kariya Y, Sonosaki T, Yamaguchi S, Hagiwara K, Uezato H, Takahashi K
  • Journal Title: J Dermatol. Volume: 43 Issue: 1 Pages: 107-108
  • DOI: 10.1111/1346-8138.13152
  • Peer Reviewed / Open Access
• [Journal Article] Three Cases of Sparganosis Mansoni : Identification of the Causative Parasite Species by PCR Methods (2016)
  • Author(s): 園崎 哲, 大久保 優子, 大嶺 卓也, 宮城 拓也, 苅谷 嘉之, 山本 雄一, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 78 Issue: 5 Pages: 522-527
  • DOI: 10.2336/nishinihonhifu.78.522
  • NAID: 130005316162
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Osteonevus of Nanta in the Lower Jaw : a Review of Japanese Cases (2016)
  • Author(s): 苅谷 嘉之, 山城 充士, 山口 さやか, 粟澤 剛, 眞鳥 繁隆, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 78 Issue: 5 Pages: 494-499
  • DOI: 10.2336/nishinihonhifu.78.494
  • NAID: 130005316177
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] デスモグレイン1遺伝子の変異による線状掌蹠角化症の小児例 (2016)
  • Author(s): 苅谷 嘉之 、山口 さやか, 内海 大介, 高橋 健造, 上里 博
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 35 Pages: 117-121
  • Peer Reviewed
• [Journal Article] 小児の手掌に生じた黒癬 (2016)
  • Author(s): 苅谷 嘉之, 山口 さやか, 大久保 優子, 高橋 健造, 上里 博, 佐野 文子
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 35 Pages: 41-46
  • Peer Reviewed
• [Journal Article] ウサギからの感染が疑われたMicrosporum canisによる頭部・体部白癬の小児例 (2015)
  • Author(s): 園崎 哲, 山口 さやか, 大久保 優子, 山本 雄一, 高橋 健造, 上里 博, 佐野 文子
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 34 Pages: 222-226
  • Peer Reviewed / Open Access
• [Journal Article] A Case Report of Borderline Lepromatous Type Leprosy in a Japanese Elderly Person (2015)
  • Author(s): 大平 葵, 山口 さやか, 新嘉喜 長, 大久保 優子, 宮城 拓也, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 5 Pages: 497-502
  • DOI: 10.2336/nishinihonhifu.77.497
  • NAID: 130005137636
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Iatrogenic Kaposi's Sarcoma of the Nasal Ala (2015)
  • Author(s): 大平 葵, 山口 さやか, 新嘉喜 長, 大久保 優子, 宮城 拓也, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 5 Pages: 492-496
  • DOI: 10.2336/nishinihonhifu.77.492
  • NAID: 130005137635
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] Conspicuous Bilateral Eyelids Swelling Appeared in a Patient with Subcutaneous Panniculitis-like T-cell Lymphoma (2015)
  • Author(s): 林 健太郎, 宮城 拓也, 園崎 哲, 山口 さやか, 山本 雄一, 高橋 健造, 西 由希子, 仲地 佐和子, 友寄 毅昭, 益崎 裕章, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 5 Pages: 487-491
  • DOI: 10.2336/nishinihonhifu.77.487
  • NAID: 130005137634
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Congenital Ectopic Nail (2015)
  • Author(s): 崎枝 薫, 粟澤 剛, 林 健太郎, 苅谷 嘉之, 眞鳥 繁隆, 川畑 有香, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 5 Pages: 473-478
  • DOI: 10.2336/nishinihonhifu.77.473
  • NAID: 130005137631
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] The Evaluation of the Utility of Nerve Blocks during Skin Surgery on the Lower Extremity (2015)
  • Author(s): 粟澤 剛, 林 健太郎, 苅谷 嘉之, 眞鳥 繁隆, 新嘉喜 長, 高橋 健造, 上里 博
  • Journal Title: The Japanese Journal of Dermatology Volume: 125 Issue: 7 Pages: 1409-1417
  • DOI: 10.14924/dermatol.125.1409
  • NAID: 130005084452
  • ISSN: 0021-499X, 1346-8146
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Cutaneous Protothecosis (2015)
  • Author(s): 大平 葵, 山口 さやか, 大久保 優子, 佐久川 裕行, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 4 Pages: 378-384
  • DOI: 10.2336/nishinihonhifu.77.378
  • NAID: 130005110174
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] Familial Outbreak of Dermatophytoses Caused by <i>Trichophyton violaceum</i> (2015)
  • Author(s): 山口 さやか, 大久保 優子, 高橋 健造, 上里 博, 佐野 文子
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 3 Pages: 239-243
  • DOI: 10.2336/nishinihonhifu.77.239
  • NAID: 130005101063
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] Successful Treatment with Concurrent Chemoradiotherapy for Advanced Perianal Squamous Cell Carcinoma (2015)
  • Author(s): 粟澤 剛, 粟澤 遼子, 林 健太郎, 眞鳥 繁隆, 山本 雄一, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 77 Issue: 3 Pages: 230-234
  • DOI: 10.2336/nishinihonhifu.77.230
  • NAID: 130005101061
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] 診断に難渋したT-cell/histiocyte rich large B-cell lymphomaの小児例 (2015)
  • Author(s): 粕谷 百合子, 大久保 優子, 眞鳥 繁隆, 苅谷 嘉之, 高橋 健造, 上里 博, 浜田 聡, 百名 伸之, 太田 孝男
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 34 Pages: 137-142
  • Peer Reviewed / Open Access
• [Journal Article] 先天性Bednar腫瘍の1例 (2015)
  • Author(s): 林 健太郎, 仲村 郁心, 眞鳥 繁隆, 粟澤 剛, 山本 雄一, 苅谷 嘉之, 高橋 健造, 上里 博
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 57 Pages: 480-481
  • Peer Reviewed / Open Access
• [Journal Article] サメハダテナガダコ咬症の1例 (2015)
  • Author(s): 大久保 優子, 内海 大介, 平良 清人, 高橋 健造, 上里 博
  • Journal Title: 皮膚科の臨床 Volume: 57 Pages: 480-481
  • Peer Reviewed / Open Access
• [Journal Article] 野生オオコウモリによる外傷後、狂犬病暴露後ワクチンを接種した1事例 (2015)
  • Author(s): 川瀬 史恵, 山口 さやか, 佐野 文子, 金野 俊洋, 兼島 孝, 玉城 佑一郎, 上里 博
  • Journal Title: 獣医畜産新報 Volume: 68 Pages: 276-278
  • Peer Reviewed / Open Access
• [Journal Article] 【日常皮膚診療に役立つアレルギー百科】 アスピリン不耐症 (2015)
  • Author(s): 宮城 拓也, 上里 博
  • Journal Title: Derma Volume: 229 Pages: 163-169
  • Open Access
• [Journal Article] 後天性免疫不全症候群に合併したBowen様丘疹症の1例 (2015)
  • Author(s): 白瀬 春奈, 粟澤 遼子, 粟澤 剛, 山本 雄一, 高橋 健造, 上里 博
  • Journal Title: 臨床皮膚科 Volume: 69 Pages: 74-77
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Chromosomal Translocation Associated With COL1A2-PDGFB Gene Fusion in Dermatofibrosarcoma Protuberans: PDGF Expression as a New Diagnostic Tool. (2015)
  • Author(s): Nakamura I, Kariya Y, Okada E, Yasuda M, Matori S, Ishikawa O, Uezato H, Takahashi K.
  • Journal Title: JAMA Dermatol Volume: 151 Issue: 12 Pages: 1330-1337
  • DOI: 10.1001/jamadermatol.2015.2389
  • Peer Reviewed / Open Access
• [Journal Article] Ayadaulin, a novel RGD peptide with dual antihemostatic activities from the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis (2015)
  • Author(s): Kato, H., Gomez, E.L., Fujita, M., Ishimaru, Y., Uezato, H., Mimori, T., Iwata, H., Hashiguchi, Y.
  • Journal Title: Biochimie Volume: 112 Pages: 49-56
  • DOI: 10.1016/j.biochi.2015.02.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Case of bilateral acroangiodermatitis due to symmetrical arteriovenous fistulas of the soles. (2015)
  • Author(s): Horiguchi Y, Takahashi K, Tanizaki H, Miyachi Y.
  • Journal Title: J Dermatol Volume: 42 Issue: 10 Pages: 989-991
  • DOI: 10.1111/1346-8138.12934
  • Peer Reviewed / Open Access
• [Journal Article] Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency. (2015)
  • Author(s): Motoki Y, Mizushima S, Taguri M, Takahashi K, Asano R, Kato H, Asai-Sato M, Katayama K, Okamoto N, Hirahara F, Miyagi E.
  • Journal Title: Clin Immunol Volume: 39 Pages: 700-706
  • Peer Reviewed / Open Access
• [Journal Article] Primary cutaneous mucormycosis caused by Mucor irregularis in an elderly person. (2014)
  • Author(s): Yamaguchi S, Okubo Y, Katano A, Sano A, Uezato H, Takahashi K.
  • Journal Title: J Dermatol Volume: 42 Issue: 2 Pages: 210-214
  • DOI: 10.1111/1346-8138.12736
  • Peer Reviewed / Open Access
• [Journal Article] Genetic divergence in populations of Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis in Ecuador and Peru (2014)
  • Author(s): Kato, H., Caceres, A.G., Gomez, E.A.L., Mimori, T., Uezato, H., Hashiguchi, Y.
  • Journal Title: Acta Tropica Volume: 141 Pages: 79-87
  • DOI: 10.1016/j.actatropica.2014.10.004
  • NAID: 120005553669
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Case of Giant Subcutaneous Dermoid Cyst of the Right Shoulder (2014)
  • Author(s): 片野 あずさ, 内海 大介, 大平 葵, 粕谷 百合子, 苅谷 嘉之, 崎枝 薫, 眞鳥 繁隆, 平良 清人, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 76 Issue: 5 Pages: 469-472
  • DOI: 10.2336/nishinihonhifu.76.469
  • NAID: 130004831884
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] A Case of a Pilomatricoma Associated with Myotonic Dystrophy Being Suspected for Squamous Cell Carcinoma (2014)
  • Author(s): 大久保 優子, 内海 大介, 苅谷 嘉之, 林 健太郎, 粟沢 剛, 眞鳥 繁隆, 高橋 健造, 上里 博
  • Journal Title: Nishi Nihon Hifuka Volume: 76 Issue: 4 Pages: 353-356
  • DOI: 10.2336/nishinihonhifu.76.353
  • NAID: 130004695271
  • ISSN: 0386-9784, 1880-4047
  • Peer Reviewed / Open Access
• [Journal Article] 仙骨部の褥瘡,褥瘡瘢痕に生じた有棘細胞癌の3例 (2014)
  • Author(s): 眞鳥 繁隆, 粟澤 遼子, 林 健太郎, 粟澤 剛, 平良 清人, 高橋 健造, 上里 博
  • Journal Title: 臨床皮膚科 Volume: 68 Pages: 815-819
  • Peer Reviewed / Open Access
• [Journal Article] An imported case of cutaneous leishmaniasis caused by Leishmania (Leishmania) donovani in Japan. (2014)
  • Author(s): Ito K, Takahara M, Ito M, Oshiro M, Takahashi K, Uezato H, Imafuku S.
  • Journal Title: J Dermatol Volume: 41 Issue: 10 Pages: 926-928
  • DOI: 10.1111/1346-8138.12609
  • Peer Reviewed / Open Access
• [Journal Article] A case of mucocutaneous leishmaniasis diagnosed by serology. (2014)
  • Author(s): Okumura Y, Yamauchi A, Nagano I, Itoh M, Hagiwara K, Takahashi K, Uezato H, Maeda M, Seishima M.
  • Journal Title: J Dermatol Volume: 41 Issue: 8 Pages: 739-42
  • DOI: 10.1111/1346-8138.12564
  • Peer Reviewed / Open Access
• [Journal Article] Glossal pigmentation caused by the simultaneous uptake of iron and tea. (2014)
  • Author(s): Yuriko KASUYA, Sayaka YAMAGUCHI, Yu-ichi YAMAMOTO, Hiroshi UEZATO, Kenzo TAKAHASHI
  • Journal Title: Eur. J. Dermatol Volume: 24 Issue: 4 Pages: 1-2
  • DOI: 10.1684/ejd.2014.2371
  • Peer Reviewed / Open Access
• [Presentation] 【CPC】診断に苦慮した右下腿紅色腫瘤 (2016)
  • Author(s): 苅谷 嘉之
  • Organizer: 日本皮膚科学会第68回西部支部学術大会
  • Place of Presentation: 米子コンベンションセンター（鳥取市）
  • Year and Date: 2016-11-19
• [Presentation] 単純黒子との鑑別を要した悪性黒色腫の 1 例 (2016)
  • Author(s): 平橋 文、佐久川裕行、山城充士、林 健太郎、新嘉喜 長、眞鳥繁隆、苅谷嘉之、山本雄一、 高橋健造
  • Organizer: 日本皮膚科学会第78回沖縄地方会
  • Place of Presentation: 沖縄県医師会館（沖縄県南風原町）
  • Year and Date: 2016-08-28
• [Presentation] 後頭部に生じた皮下型隆起性皮膚線維肉腫の1例 (2016)
  • Author(s): 粟澤 剛、苅谷嘉之、眞鳥繁隆、新嘉喜長、粟澤遼子、高橋健造、上里博
  • Organizer: 第32回皮膚悪性腫瘍学会学術大会
  • Place of Presentation: かごしま県民交流センター（鹿児島市）
  • Year and Date: 2016-05-27
• [Presentation] 術中迅速診断における全断面評価のための新しい切出し方法についての検討 (2015)
  • Author(s): ：苅谷 嘉之, 粟澤 剛, 林 健太郎, 崎枝 薫, 眞鳥 繁隆, 高橋 健造, 上里 博
  • Organizer: Source： 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 31回
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-07-03
• [Presentation] 抗体製剤時代の乾癬の外用治療 外用薬による長期副作用の理解 (2015)
  • Author(s): 高橋健造
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-29
• [Presentation] スミスリン抵抗性の沖縄のアタマジラミ症への対応 (2015)
  • Author(s): 高橋健造、石井則久
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-29
• [Presentation] 沖縄の地理と公衆衛生上の課題から再認識する、乾癬の病態と治療選択 (2015)
  • Author(s): 高橋健造
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-29
• [Presentation] 遺伝性角化症患者の表皮と毛、毛包の観察 (2015)
  • Author(s): 高橋健造、須賀 康
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-29
• [Remarks] http://w3.u-ryukyu.ac.jp/dermatology/