| Project/Area Number |
26461699
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
ASADA HIDEO 奈良県立医科大学, 医学部, 教授 (60252681)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
宮川 史 奈良県立医科大学, 医学部, 講師 (00346024)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MORI YASUKO 神戸大学, 医学部, 教授 (50343257)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 薬剤性過敏症症候群 / DIHS / HHV-6 / ヒトヘルペスウイルス / 再活性化 / TARC / ケモカイン / CD134 / ウイルスレセプター / MDC |
|---|
| Outline of Final Research Achievements |
HHV-6 reactivation is involved in the pathogenesis of drug-induced hypersensitivity syndrome (DIHS), but the reactivation mechanism is still unclear. In this study, we aimed to elucidate the mechanism of HHV-6 reactivation focusing on the marked elevation of Th2-related chemokine (TARC) in the acute phase of DIHS and the fact that HHV-6 has TARC receptor.
As a result, we found that HHV-6 receptor (CD134) markedly increased on the T cell surface correlated with the elevation of serum TARC level in the acute phase of DIHS, and that blood HHV-6 DNA amount was also correlated with serum TARC level. These findings suggested that increased expression of CD134 associated with elevated TARC might be involved in HHV-6 reactivation in vivo.
|
