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Clarification of the pathogenesis of atopic disease by using filaggrin deficient mice in dry environment

Research Project

Project/Area Number 26461702
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

Kawasaki Hiroshi  慶應義塾大学, 医学部(信濃町), 共同研究員 (70445344)

Co-Investigator(Kenkyū-buntansha) 塩濱 愛子  慶應義塾大学, 医学部(信濃町), 特任助教 (40383731)
久保 亮治  慶應義塾大学, 医学部(信濃町), 准教授 (70335256)
天谷 雅行  慶應義塾大学, 医学部(信濃町), 教授 (90212563)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords皮膚バリア / アトピー性皮膚炎 / フィラグリン
Outline of Final Research Achievements

We aimed to clarify the pathogenesis that stratum corneum function of filaggrin deficient mice was exacerbated by the dry condition and lead to develop atopic disease, by using the filaggrin deficient mouse model grown in dry environment. Excessive barrier dysfunction and aberrant percutaneous sensitization were evident in the mice kept in dry condition, and these extents were more obvious in filaggrin deficient mice. Skin transcriptomic analysis of differentially expressed genes (DEG) between filaggrin deficient and wild-type mice revealed that very few genes were differentially expressed in normal humidity condition as compared with DEG in dry condition, suggesting that the impact of filaggrin deficiency was not significant in humid condition. Thus, we demonstrated that functional disorder due to filaggrin deficiency had an impact on phenotypic expression of the mice, closely associated with environmental factor of humidity.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] フィラグリン欠損マウスの角層バリア機能破綻に対する乾燥環境因子の関与2014

    • Author(s)
      川崎 洋, 久保 亮治, 平野 尚茂, 山田 健人, 天谷 雅行
    • Organizer
      第42回臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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