| Project/Area Number |
26461712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
音羽 健司 帝京平成大学, 臨床心理学研究科, 教授 (70456119)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | Panic disorder / genome wide / association study / pathway analysis / epigenome study / HLA genes / パニック症 / HLA / 免疫系 / DNAメチル化 / 遺伝子 / 全ゲノム関連解析 / DNAメチル化関連解析 / パニック障害 / パスウェイ解析 |
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| Outline of Final Research Achievements |
In this study, we performed genome and epigenome studies to identify new genetic factors associated with panic disorder. In the genome study, we performed pathway analyses, identifying the association between immune-related pathways and panic disorder. We also genotyped the HLA genes and found that HLA-DRB1*13:02 was associated with the disease. Further, epigenome-wide association study of DNA methylation was conducted and forty CpG sites were identified as candidate methylation sites associated with panic disorder. A pathway analysis on the genes annotated to the significant CpG sites identified several pathways, including “positive regulation of lymphocyte activation.”
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