Search for new susceptibility genetic factor associated with panic disorder
Project/Area Number |
26461712
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
音羽 健司 帝京平成大学, 臨床心理学研究科, 教授 (70456119)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | Panic disorder / genome wide / association study / pathway analysis / epigenome study / HLA genes / パニック症 / HLA / 免疫系 / DNAメチル化 / 遺伝子 / 全ゲノム関連解析 / DNAメチル化関連解析 / パニック障害 / パスウェイ解析 |
Outline of Final Research Achievements |
In this study, we performed genome and epigenome studies to identify new genetic factors associated with panic disorder. In the genome study, we performed pathway analyses, identifying the association between immune-related pathways and panic disorder. We also genotyped the HLA genes and found that HLA-DRB1*13:02 was associated with the disease. Further, epigenome-wide association study of DNA methylation was conducted and forty CpG sites were identified as candidate methylation sites associated with panic disorder. A pathway analysis on the genes annotated to the significant CpG sites identified several pathways, including “positive regulation of lymphocyte activation.”
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Epigenome-wide association study of DNA methylation in panic disorder2017
Author(s)
Shimada-Sugimoto, M., T. Otowa, T. Miyagawa, T. Umekage, Y. Kawamura, M. Bundo, K. Iwamoto, M. Tochigi, K. Kasai, H. Kaiya, H. Tanii, Y. Okazaki, K. Tokunaga and T. Sasaki
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Journal Title
Clinical Epigenetics
Volume: 9
Issue: 1
Pages: 6-6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.2016
Author(s)
Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor S-S, Omae Y, Toyo-oka L, Sugaya N, Kawamura Y, Umekage T, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, Sasaki T
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Journal Title
Human Genome Variation
Volume: 3
Issue: 1
Pages: 16001-16001
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Candidate Genes in Panic Disorder: Meta-Analyses of 23 Common Variants in Major Anxiogenic Pathways.2015
Author(s)
Howe AS, Buttenschon H, Bani-Fatemi A, Maron E, Otowa T, Erhardt A, Binder EB, Gregersen N, Domschke K, Reif A, Shlik J, Koks S, Kawamura Y, Miyashita A, Kuwano R, Tokunaga K, Tanii H, Sasaki T, Smoller JW, De Luca1 V
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Journal Title
Molecular Psychiatry
Volume: 20
Issue: 5
Pages: 1-15
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Anger tendency may be associated with duration of illness in panic disorder.2015
Author(s)
Sugaya N, Yoshida E, Yasuda S, Tochigi M, Takei K, Otowa T, Umekage T, Konishi Y, Sakano Y, Nomura S, Okazaki Y, Kaiya H, Tanii H, Sasaki T,
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Journal Title
BioPsychoSocial Medicine
Volume: 9
Issue: 1
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel rare variations of the oxytocin receptor (OXTR) gene in autism spectrum disorder individuals.2015
Author(s)
Liu X, Kawashima M, Miyagawa T, Otowa T, Latt KZ, Thiri M, Nishida H, Sugiyama T, Tsurusaki Y, Matsumoto N, Mabuchi A, Tokunaga K, Sasaki T.
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Journal Title
Human Genome Variation
Volume: 2
Issue: 1
Pages: 15024-15024
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] パニック症のゲノムワイド関連解析のHLAアリルによる層別解析2016
Author(s)
杉本美穂子, 音羽健司, 宮川卓, Khor Seik-Soon, 大前陽輔, 豊岡理人, 柏瀬貢一, 小島裕人, 二神貴臣, 佐治博夫, 佐々木司, 徳永勝士
Organizer
日本組織適合性学会
Place of Presentation
北海道札幌市
Year and Date
2016-10-23
Related Report
Int'l Joint Research
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[Presentation] Epigenome-wide association study of DNA methylation in panic disorder2016
Author(s)
Mihoko Shimada-Sugimoto, Takeshi Otowa, Taku Miyagawa, Nagisa Sugaya, Yoshiya Kawamura, Tadashi Umekage, Hisanobu Kaiya, Kiyoto Kasai, Hisashi Tanii, Yuji Okazaki, Katsushi Tokunaga and Tsukasa Sasaki
Organizer
America Society of Human Genetics 2016
Place of Presentation
Vancouver
Year and Date
2016-10-21
Related Report
Int'l Joint Research
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[Presentation] Genome-wide association study in a Japanese sample identifies candidate loci for HLA-DRB1*13:02-negative panic disorder2016
Author(s)
Mihoko Shimada, Takeshi Otowa, Taku Miyagawa, Seik-Soon Khor, Yosuke Omae, Licht Toyo-oka, Nagisa Sugaya, Yoshiya Kawamura, Tadashi Umekage, Akinori Miyashita, Ryozo Kuwano, Hisanobu Kaiya, Kiyoto Kasai, Hisashi Tanii, Yuji Okazaki, Katsushi Tokunaga, Tsukasa Sasaki
Organizer
The 13th International Congress of Human Genetics
Place of Presentation
Kyoto
Year and Date
2016-04-03
Related Report
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