| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study I have focused on chiral-specificity of amino acids to understand molecular basis in developing novel antipsychotic drugs for schizophrenia. D-Serine, an NMDA receptor coagonist, plays a crucial role in neurocognitive functions. From a pathophysiological aspect, dysfunction of D-serine/NMDA receptor signaling system may be involved in schizophrenia-related symptoms. To obtain further insights into the molecular basis of schizophrenia and other related mental disorders, I have investigated the genetic association of candidate genes and schizophrenia as case-control study. I obtained profiles of the relationship of these genes, including the splicing system of them, and schizophrenia.
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