| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
We investigated the mechanism of weight gain and glucose metabolism due to atypical antipsychotic drugs in children and adults. Regarding changes in body weight for children, there were no differences between drugs in the 3 groups of aripiprazole, risperidone, and olanzapine. There was no association between glucose- dependent insulinotropic polypeptide (GIP) receptor gene polymorphism and metabolic syndrome in adults. We observed the difference in area under the curve of the GIP concentration after glucose tolerance between aripiprazole, olanzapine and quetiapine. We reveals a difference in HDL-cholesterol levels in overweight Japanese inpatients with schizophrenia resulting from the use of different antipsychotics.
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