| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we conducted comprehensive methylation analysis using peripheral blood with the aim of developing a diagnostic method for postpartum depression (PPD). A total of 18 female cases and 18 female controls were enrolled. We performed a case-control study to examine the association of DNA methylation (DNAm) status (p＜1.3E-7). After that we conducted functional enrichment analysis of PPD. We observed no genome-wide significant association between the genome-wide measure of DNAm based on all CpG sites and PPD. From a result of comparing the case-control DNAm level, we selected 1,000 sites with low p-values and conducted functional enrichment analysis. As a result of enrichment analysis we found four GO Terms. From the results of this study, we confirmed that not only a single methylation site but also an analysis focusing on their functional relevance was useful for development of a diagnostic method for postpartum depression.
|
