An intermediate phenotype study of clinical responses of obsessive-compulsive disorder by using high resolution MRS and NIRS
| Project/Area Number |
26461720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SUMITANI Satsuki 徳島大学, 大学院医歯薬学研究部(総合支援), 教授 (90346594)
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| Co-Investigator(Kenkyū-buntansha) |
沼田 周助 徳島大学, 病院, 講師 (10403726)
原田 雅史 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20228654)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 強迫性障害 / 薬物応答遺伝子 / 中間表現型 / GWAS / MRS / NIRS / SSRI / 非定型抗精神病薬 / 強迫性障害（OCD） / 薬物応答性 / ゲノムワイドジェノタイピング / 5-HTTLPR / COMT |
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| Outline of Final Research Achievements |
We studied to find genetic factors involved in clinical responses of obsessive-compulsive disorder (OCD) by using high resolusion proton magnetic resonance spectroscopy (MRS) and multichannel near infrared spectroscopy (NIRS). While we failed to detect specific genetic variants associated with clinical responses to SSRI or to SSRI with an atypical antipsychotic at genome-wide levels of significance, we identified 8 enriched pathways for the SSRI treatment response and 5 enriched pathways for the treatment response to SSRI with an antipsychotic medication. Moreover we found responders to SSRI showed different activation during the Stroop task compared to responders to SSRIs with antipsychotics by using NIRS. Our results may provide novel insight to predict clinical response in OCD patients.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] 1H-magnetic resonance spectroscopy study of glutamate-related abnormality in bipolar disorder.2017
Author(s)
Kubo H, Nakataki M, Sumitani S, Iga JI, Numata S, Kameoka N, Watanabe SY, Umehara H, Kinoshita M, Inoshita M, Tamaru M, Ohta M, Nakayama-Yamauchi C, Funakoshi Y, Harada M, Ohmori T.
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Journal Title
J Affect Disord.
Volume: 208
Pages: 139-144
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Blood Diagnostic Biomarkers for Major Depressive Disorder using Multiplex DNA Methylation Profiles: Discovery and Validation.2015
Author(s)
Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-Ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku, Akitoyo Hishimoto, Shinji Shimodera, Issei Imoto, Shigeru Morinobu, Tetsuro Ohmori
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Journal Title
Epigenetics
Volume: 10(2)
Issue: 2
Pages: 135-141
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Blood diagnostic biomarkers for major depressive disorder using DNA methylation profiles.2014
Author(s)
Numata S, Kazuo I, Tajima A, Iga JI, Kinoshita M, Watanabe S, Umehara H, Fuchikami M, Okada S, Shimodera S, Imoto I, Morinobu S, Ohmori T.
Organizer
Neuroscience
Place of Presentation
Washington Convention Center, Washington DC
Year and Date
2014-11-15 – 2014-11-19
Related Report
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