Social function recovery in schizophrenia: brain mechanism of empathy/concerning function using stem cells and oxytocin
Project/Area Number |
26461724
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Sapporo Medical University |
Principal Investigator |
Ukai Wataru 札幌医科大学, 医療人育成センター, 准教授 (40381256)
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Co-Investigator(Kenkyū-buntansha) |
橋本 恵理 札幌医科大学, 医学部, 准教授 (30301401)
石井 貴男 札幌医科大学, 医学部, 助教 (40404701)
木川 昌康 札幌医科大学, 医学部, 助教 (50581146)
相馬 仁 札幌医科大学, 医療人育成センター, 教授 (70226702)
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Co-Investigator(Renkei-kenkyūsha) |
Iwamoto Kazuya 熊本大学, 医学部, 教授 (40342753)
Morimoto Takafumi 札幌医科大学, 保健医療学部, 講師 (60516730)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 統合失調症 / オキシトシン / 細胞治療 / 再生医療 / 社会性機能 / GABA系インターニューロン / 共感・気遣い / バソプレッシン / 幹細胞療法 |
Outline of Final Research Achievements |
First, we analyzed the social functioning behavior of model animals administered with stem cells and the distribution of cells in the brain. We detected that the patient-derived stem cells was difficult to become GAD67 and Parvalbumin-positive GABA interneurons in the brain after administration, and social interaction behavior was decreased in the patient-derived stem cell administered group compared to the control and healthy-derived stem cell administered group. Next, the synapse forming ability of the GABAergic interneuron was analyzed by the actin motility of the precursor structure filopodia, and found the reduction of the filopodia movement in the patient-derived cells. We also found that the possibility of the influence of decreased expression of the transcription factor TBX1 against it.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] The usefulness of combined brain perfusion single-photon emission computed tomography, Dopamine-transporter single-photon emission computed tomography, and 123I-metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies.2017
Author(s)
Kobayashi S, Makino K, Hatakeyama S, Ishii T, Tateno M, Iwamoto T, Tsujino H, Kawasaki K, Mikuni K, Ukai W, Murayama T, Hashimoto E, Utsumi K, Kawanishi C.
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Journal Title
Psychogeriatrics.
Volume: 未
Issue: 4
Pages: 247-255
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The effect of APOE ε4 allele on brain perfusion SPECT in late onset Alzheimer’s disease by an automated program, 3DSRT.2016
Author(s)
Kobayashi S, Ishii T, Tateno M, Sohma H, Kokai Y, Ito YM, Iwamoto T. Furuse K, Tsujino H, Morii H, Ukai W, Hashimoto E, Utsumi K, Kawanishi C.
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Journal Title
Neuropsychiatry
Volume: 6
Pages: 55-63
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Pathological analysis of refractory depression using fetal alcohol and adolescent corticosterone double stress model2016
Author(s)
Furuse K, Tsujino H, Kigawa Y, Tayama M, Ukai W, Ishii T, Iwamoto T, Shiraishi M, Kobayashi S, Hashimoto E, kawanishi C.
Organizer
30th CINP World Congress
Place of Presentation
Seoul, Korea
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Amelioration of treatment-refractory depression with intravenous stem cells: potential actions of boosting the antidepressant effect2015
Author(s)
Ukai W, Furuse K, Kigawa Y, Tsujino H, Ishii T, Tayama M, Iwamoto T, Shiraishi M, Kobayashi S, Hashimoto E, Kawanishi C
Organizer
Collegium Internationale Neuro- Psychopharmacologicum (CINP)
Place of Presentation
Dublin, Ireland
Year and Date
2015-06-04
Related Report
Int'l Joint Research
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[Presentation] 2.Stem cell therapy: a regenerative approach for refractory psychiatric diseases2015
Author(s)
Ukai W, Furuse K, Kigawa Y, Tsujino H, Ishii T, Tayama M, Iwamoto T, Shiraishi M, Inoue K, Kobayashi S, Hashimoto E, Kawanishi C
Organizer
Korean Society for Biochemistry and Molecular Biology (KSBMB)
Place of Presentation
Seoul, Korea
Year and Date
2015-05-12
Related Report
Int'l Joint Research / Invited
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