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Searching for mechanism of antipsychotic action; modulation of Kv3 channel family

Research Project

Project/Area Number 26461727
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKindai University

Principal Investigator

YANAGI Masaya  近畿大学, 医学部, 講師 (10418775)

Co-Investigator(Kenkyū-buntansha) 白川 治  近畿大学, 医学部, 教授 (40243307)
Research Collaborator TAMMINGA CA  University of Texas Southwestern Medical Center, Professor
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords抗精神病薬 / 統合失調症 / Kv3ファミリー / Kv3.1 / Kv3.2 / GAD65 / GAD67 / 前頭葉 / パルブアルブミンニューロン / 定型抗精神病薬 / 非定型抗精神病薬 / 前頭前野 / Kv3.1 / Kv3.2
Outline of Final Research Achievements

In this study, we found that haloperidol, a typical APD and risperidone, an atypical APD differentially modulated cortical Kv3.1 and Kv3.2 channels. While both haloperidol and risperidone significantly increased Kv3.1 protein levels in rat prefrontal cortex, Kv3.2 protein levels showed an increase and a decrease in the same region by haloperidol and risperidone, respectively. A similar pattern of Kv3.2 change was found in cerebellum, however, no significant changes were found in Kv3.2 protein levels in hippocampus, thalamus and striatum. These result were reported in Annual Meeting of the Japanese Society of Psychiatry and Neurology.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 定形および非定形抗精神病薬によるKv3.2カリウムイオンチャンネルの発現調節2016

    • Author(s)
      柳雅也、白川治、Carol A. Tamminga
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      千葉県 幕張メッセ
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2020-01-20  

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