Prediction for relapse of major depression based on BDNF, and proBDNF

• Project/Area Number: 26461728
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: Yoshimura Reiji 産業医科大学, 医学部, 教授 (90248568)
• Co-Investigator(Kenkyū-buntansha): 中村 純 産業医科大学, 医学部, 非常勤講師 (40148804) ; 堀 輝 産業医科大学, 医学部, 講師 (50421334)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 精神薬理 / メンタルヘルス / 脳画像 / ゲノム / バイオマーカー / うつ病 / 再発 / 予測 / BDNF / proBDNF / IL6

Outline of Final Research Achievements

Fifty-eight remitted patients in major depressive disorder (MDD) were followed up at least one year. We measured serum levels of brain-derived neurotrophic factor (BDNF), proBDNF, and interleukin-6(IL6), which are considered to be biological markers for MDD. (1)Twenty-four of 58 MDD patients were relapsed within 6 months after remission. (2)No differences were found in serum levels of BDNF proBDNF, and IL6 at baseline in the relapsed group and the non-relapsed group. (2)Serum BDNF levels were significantly lower in the relapsed group than in non-relapsed group at 3 months after remission. (3)Serum IL6 levels were significantly higher in the relapsed group than in the non-relapsed group at 3 months after remission. (4)No diference was found in serum proBDNF levels between the relapsed group and the non-relapsed group. The findings suggest that serum levels of BDNF, and IL6 might be predictable biomarkers for relapse in MDD.

Research Products

• [Journal Article] Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder. (2017)
  • Author(s): Yoshimura R, Katsuki A, Atake K, Hori H
  • Journal Title: Neuropsychiatr Dis Treat Volume: 13 Pages: 437-441
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between the hippocampal shape abnormality and serum cortisol levels in first-episode and drug-naïve major depressive disorder patients. (2017)
  • Author(s): Yoshimura R, Katsuki A, Atake K, Hori H
  • Journal Title: Depress Anxiety Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Can Plasma Level of 3-methoxy-4-hydroxyphenylglycol Predict the Response for Selective Serotonin Reuptake Inhibitor and Serotonin Noradrenaline Reuptake Inhibitor in Major Depressive Disorder? (2017)
  • Author(s): Yoshimura R, Katsuki A, Atake K, Hori H
  • Journal Title: J Depression Anxiety Volume: 印刷中
  • Open Access / Acknowledgement Compliant
• [Journal Article] Serum brain-derived neurotrophic factor level, plasma 3-methoxy-4-hydroxyphenylglycol level in major depressed patients with paroxetine monotherapy. (2016)
  • Author(s): Yoshimura R, Katsuki A, Akake K, Hori H
  • Journal Title: J Depression Anxiety Volume: 5 Issue: 3 Pages: 1-5
  • DOI: 10.4172/2167-1044.1000234
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Blood Biological Markers for Prediction of Escitalopram Response in Patients with Major Depressive Disorder: Preliminary Study (2016)
  • Author(s): Yoshimura R, Katsuki A, Atake K, Hori H
  • Journal Title: J Depression Anxiety Volume: 5 Issue: 02 Pages: 1-5
  • DOI: 10.4172/2167-1044.1000222
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in HealthySubjects:Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging. (2015)
  • Author(s): Watanabe K,Kakeda S,Yoshimura R,Ide S,Hayashi K,Katsuki A,Umene-Nakano W,Watanabe R,Abe O,Korogi Y.
  • Journal Title: Plos One. Volume: 10 Pages: 11-11
  • Peer Reviewed
• [Journal Article] Individually Safe and Realistic Correction of Antipsychotic Polypharmacy and High-dose Regimens in Jaoanese Patients with Chronic Schizophrenia:The SCAP method. (2015)
  • Author(s): Yamanouchi Y,Sukegawa T,Inagaki A,Inada T,Yoship T,Yoshimura R,Iwata N.
  • Journal Title: Seishin Shinkeigaku Zasshi Volume: 117 Pages: 305-311
  • Peer Reviewed
• [Journal Article] RELATIONSHIP BETWEEN THE CORTICAL THICKNESS AND SERUM COTISOL LEVELS IN DRUG-NAIVE,FIRST-EPISODE PATIENTS WITH MAJOR DEPRESSIVE DISORDER:A SURFACE-BASED MORPHOMETRIC STUDY. (2015)
  • Author(s): Lix X,KakedaS,Watanabe K,Yoshimura R,Abe O,Ide S,Hayashi K,Katsuki A,Umene-NakanoW,Watanabe R,Ueda I,Moriya J,Nkamura J,Korogi Y.
  • Journal Title: Depress Anxiety Volume: 32(9) Pages: 702-708
  • Peer Reviewed
• [Journal Article] Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder:A VBM analysis of brain MRI. (2015)
  • Author(s): Watanabe K,Kakeda S,Yoshimura R,Abe O,Ide S,Hayashi K,Katsuki A,Umene-Nakano W,Iwata N,Nakamura J,Korogi Y.
  • Journal Title: Psychiatry Res. Volume: 233(2) Pages: 120-124
  • Peer Reviewed
• [Journal Article] Catechol-O-methyltransferase Val158Met genotype and the clinical responses to duloxetine treatment or plasma levels of 3-methoxy-4-hydroxyphenylglycol and homovanillic acid in Japanese patients with major depressive disorder. (2015)
  • Author(s): Atake K,Yoshimura R,Hori H,Katsuki A,Nakamura J.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 3(11) Pages: 967-974
  • Peer Reviewed
• [Journal Article] No support for replication of the genetic variants identified by a recent mega-analysis of the treatment response to antidepressants. (2015)
  • Author(s): Hatano M,Ikeda M,Kondo K,Saito T,Shimasaki A,Esaki K,Umene-Nkano W,Yoshimura R,Nakamura J,Ozaki N,Iwata N.
  • Journal Title: J Hun Genet Volume: 60(6) Pages: 343-344
  • Peer Reviewed
• [Journal Article] Relationships between brain-derived neurotrophic factor, clinical symptoms, and decision-making in chronic schizophrenia: data from the Iowa Gambling Task. (2014)
  • Author(s): Hori H, Yoshimura R, Katsuki A, Atake K, Nakamura J.
  • Journal Title: Front Behav Neurosci. Volume: 8 Pages: 417-417
  • DOI: 10.3389/fnbeh.2014.00417
  • Peer Reviewed
• [Journal Article] Serum proBDNF/BDNF and response to fluvoxamine in drug-naïve first-episode major depressive disorder patients (2014)
  • Author(s): Yoshimura R, Kishi T, Hori H, Atake K, Katsuki A, Nakano-Umene W, Ikenouchi-Sugita A, Iwata N, Nakamura J.
  • Journal Title: Ann Gen Psychiatry. Volume: 13 Issue: 1 Pages: 13-19
  • DOI: 10.1186/1744-859x-13-19
  • Peer Reviewed
• [Journal Article] COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study. (2014)
  • Author(s): Hayashi K, Yoshimura R, Kakeda S, Kishi T, Abe O, Umene-Nakano W, Katsuki A, Hori H, Ikenouchi-Sugita A, Watanabe K, Ide S, Ueda I, Moriya J, Iwata N, Korogi Y, Kubicki M, Nakamura J.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 10 Pages: 1183-90
  • DOI: 10.2147/ndt.s61275
  • Peer Reviewed
• [Journal Article] Duloxetine, a Selective Noradrenaline Reuptake Inhibitor, Increased Plasma Levels of 3-Methoxy-4-hydroxyphenylglycol but Not Homovanillic Acid in Patients with Major Depressive Disorder. (2014)
  • Author(s): Atake K, Yoshimura R, Hori H, Katsuki A, Ikenouchi-Sugita A, Umene-Nakano W, Nakamura J.
  • Journal Title: Clin Psychopharmacol Neurosci.. Volume: 12(1) Issue: 1 Pages: 37-40
  • DOI: 10.9758/cpn.2014.12.1.37
  • Peer Reviewed
• [Journal Article] Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs (2014)
  • Author(s): Yoshimura R, Kishi T, Hori H, Katsuki A, Sugita-Ikenouchi A, Umene-Nakano W, Atake K, Iwata N, Nakamura J
  • Journal Title: Psychiatry Investig. Volume: 11(1.) Issue: 1 Pages: 84-8
  • DOI: 10.4306/pi.2014.11.1.84
  • Peer Reviewed
• [Journal Article] No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia. (2014)
  • Author(s): Kishi T, Fukuo Y, Moriwaki M, Iwata N, Hori H, Yoshimura R, Katsuki A, Ikenouchi-Sugita A, Atake K, Umene-Nakano W, Nakamura J, Kaneda Y, Fujita K.
  • Journal Title: Psychiatry Res. Volume: 215(3) Issue: 3 Pages: 803-5
  • DOI: 10.1016/j.psychres.2013.12.057
  • Peer Reviewed
• [Presentation] 大うつ病患者でのパロキセチン単剤治療と血中BDNF, MHPG濃度 (2016)
  • Author(s): 吉村玲児
  • Organizer: 第回日本臨床精神薬理学会
  • Place of Presentation: ホルトホール大分（大分県大分市）
  • Year and Date: 2016-11-17
• [Presentation] Plasma MHPG level and the response to antidepressants (2016)
  • Author(s): Yoshimura R
  • Organizer: 20th ECNP
  • Place of Presentation: Vienna(Austlia)
  • Year and Date: 2016-09-17
  • Int'l Joint Research
• [Presentation] Response presicion for escitaroplam (2016)
  • Author(s): 吉村玲児
  • Organizer: 第13回日本うつ病学会
  • Place of Presentation: ウインクあいち（愛知県名古屋市）
  • Year and Date: 2016-08-05
• [Book] 今日の治療指針 (2016)
  • Author(s): 吉村玲児
  • Total Pages: 2096
  • Publisher: 医学書院
• [Book] 今日の精神疾患治療指針 (2016)
  • Author(s): 吉村玲児
  • Total Pages: 1029
  • Publisher: 医学書院
• [Book] 精神科薬物療法 (2015)
  • Author(s): 吉村 玲児
  • Publisher: 医学書院
• [Book] 精神疾患のバイオマーカー (2015)
  • Author(s): 中村 純
  • Total Pages: 286
  • Publisher: 星和書店