| Project/Area Number |
26461728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 純 産業医科大学, 医学部, 非常勤講師 (40148804)
堀 輝 産業医科大学, 医学部, 講師 (50421334)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 精神薬理 / メンタルヘルス / 脳画像 / ゲノム / バイオマーカー / うつ病 / 再発 / 予測 / BDNF / proBDNF / IL6 |
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| Outline of Final Research Achievements |
Fifty-eight remitted patients in major depressive disorder (MDD) were followed up at least one year. We measured serum levels of brain-derived neurotrophic factor (BDNF), proBDNF, and interleukin-6(IL6), which are considered to be biological markers for MDD. (1)Twenty-four of 58 MDD patients were relapsed within 6 months after remission. (2)No differences were found in serum levels of BDNF proBDNF, and IL6 at baseline in the relapsed group and the non-relapsed group. (2)Serum BDNF levels were significantly lower in the relapsed group than in non-relapsed group at 3 months after remission. (3)Serum IL6 levels were significantly higher in the relapsed group than in the non-relapsed group at 3 months after remission. (4)No diference was found in serum proBDNF levels between the relapsed group and the non-relapsed group. The findings suggest that serum levels of BDNF, and IL6 might be predictable biomarkers for relapse in MDD.
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