Development of the animal models and diagnostic methods of dementia based on the molecular and pathological analyses of conformational abnormality of aggregated proteins
Project/Area Number |
26461733
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | University of Tsukuba |
Principal Investigator |
ARAI Tetsuaki 筑波大学, 医学医療系, 教授 (90291145)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 認知症 / 蛋白質 / 病理 / 変性 |
Outline of Final Research Achievements |
We analyzed pathological tau in cases with Alzheimer's disease, Pick's disease, corticobasal degeneration and progressive supranuclear palsy. We found that immunoblot analysis of trypsin-resistant tau showed the different band patterns of the fragments among these diseases, reflecting different conformations of tau molecular species. Protein sequence and mass spectrometric analyses revealed the carboxyl-terminal region of tau comprises the protease-resistant core units of the tau aggregates. These unique assembled tau cores may be used to classify and diagnose disease strains. Furthermore, to investigate the influence of a decline in progranulin on neurodegenerative diseases, brains of granulin mutation cases were analyzed. Results showed a neuronal and glial accumulation of tau andα-synuclein in addition to that of TDP-43. These results suggest that progranulin reduction might be the cause of multiple proteinopathies due to the accelerating accumulation of abnormal proteins.
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Report
(4 results)
Research Products
(100 results)
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[Journal Article] Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.2016
Author(s)
Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
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Journal Title
Acta Neuropathol Commun
Volume: 4
Issue: 1
Pages: 36-36
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.2016
Author(s)
Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DM, Iwatsubo T, Hasegawa M.
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Journal Title
Acta Neuropathol.
Volume: 131(2)
Issue: 2
Pages: 267-280
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation.2015
Author(s)
Nagata E, Nonaka T, Moriya Y, Fujii N, Okada Y, Tsukamoto H, Itoh J, Okada C, Satoh T, Arai T, Hasegawa M, Takizawa S.
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Journal Title
Mol Neurobiol.
Volume: -
Issue: 8
Pages: 5377-5383
DOI
Related Report
Peer Reviewed
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[Journal Article] Inositol hexakisphosphate kinase 2 promotes cell death in cells with cytoplasmic TDP-43 aggregation.2015
Author(s)
Nagata E, Nonaka T, Moriya Y, Fujii N, Okada Y, Tsukamoto H, Itoh J, Okada C, Satoh T, Arai T, Hasegawa M, Takizawa S
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Journal Title
Mol Neurobiol.
Volume: 0
Pages: 0-0
Related Report
Peer Reviewed
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[Journal Article] Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study.2015
Author(s)
Yoshita M, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakajima K, Nakamura H, Nakano S, Nakashima K, Nishio Y, et al.
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Journal Title
PLoS One
Volume: 10
Issue: 3
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years2014
Author(s)
Kondo D, Hino H, Shibuya K, Fujisawa K, Kosaka K, Hirayasu Y, Yamamoto R, Kasanuki K, Minegishi M, Sato K, Hosokawa M, Arai T, Arai H, Iseki E
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Journal Title
Neuropathology
Volume: Epub ahead of print
Issue: 3
Pages: 280-288
DOI
Related Report
Peer Reviewed
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[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia2014
Author(s)
Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
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Journal Title
Acta Neuropathol
Volume: Commun 2
Issue: 1
Pages: 40-40
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 認知症と異常蛋白.2016
Author(s)
新井哲明
Organizer
第35回日本認知症学会学術集会
Place of Presentation
東京国際フォーラム 東京 千代田区
Year and Date
2016-12-01
Related Report
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[Presentation] うつ状態と著明な体重減少で精神科に受診した後、呼吸不全となったFTD-MNDを疑う3症例.2016
Author(s)
野尻 美流, 塚田 恵鯉子, 三宅 善嗣, 森山 哲也, 田村 昌士, 石川 和宏, 入山 大希, 加藤 幹朗, 辻 浩史, 中馬越 清隆, 石井 一弘, 石川 正憲, 玉岡 晃, 新井 哲明
Organizer
第112回日本精神神経学会学術総会
Place of Presentation
幕張メッセ 千葉 千葉
Year and Date
2016-06-02
Related Report
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[Presentation] 平成27年関東・東北豪雨における常総市水害支援(1)茨城県こころのケアチームの急性期活動.2016
Author(s)
高橋 晶, 太刀川 弘和, 今村 芳博, 石川 正憲, 根本 清貴, 南場 陽一, 塚田 恵鯉子, 石川 和宏, 河合 伸念, 堀 孝文, 新井 哲明, 高橋 祥友
Organizer
第112回日本精神神経学会学術総会
Place of Presentation
幕張メッセ 千葉 千葉
Year and Date
2016-06-02
Related Report
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[Presentation] 平成27年関東・東北豪雨における常総市水害支援(3)茨城県認知症疾患医療センターの訪問活動.2016
Author(s)
新井 哲明, 安部 秀三, 岡田 正樹, 須磨崎 加寿子, 高濱 浩輔, 田中 芳郎, 山田 武, 高橋 晶, 根本 清貴, 太刀川 弘和, 河合 伸念, 東 晋二, 塚田 恵鯉子, 江湖山 さおり, 堀 孝文
Organizer
第112回日本精神神経学会学術総会
Place of Presentation
幕張メッセ 千葉 千葉
Year and Date
2016-06-02
Related Report
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[Presentation] 変性(タウ)12016
Author(s)
新井哲明
Organizer
第57回日本神経病理学会総会学術研究会
Place of Presentation
ホテルニューキャッスル 青森 弘前
Year and Date
2016-06-01
Related Report
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[Presentation] 初診時に緊張病症候群と診断された FTLD-TDP の一例.2016
Author(s)
渡辺亮平, 河上緒, 朝岡俊泰, 大島健一, 新里和弘, 東 晋二, 女屋光基, 新井信隆, 長谷川成人, 秋山治彦, 新井哲明
Organizer
第57回日本神経病理学会総会学術研究会
Place of Presentation
ホテルニューキャッスル 青森 弘前
Year and Date
2016-06-01
Related Report
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[Presentation] PSPとCBPの生化学2015
Author(s)
新井哲明
Organizer
第34回日本認知症学会学術集会
Place of Presentation
青森(リンクステーションホール青森・ホテル青森)
Year and Date
2015-10-02
Related Report
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[Presentation] 肝性脳症にうつ病を併発した1例2015
Author(s)
山本駿, 塚田恵鯉子, 野尻美流, 福田邦明, 新井哲明
Organizer
第104回東京精神医学会学術集会
Place of Presentation
東京(東京大学医学部附属病院 入院棟A 15階 大会議室)
Year and Date
2015-07-04
Related Report
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[Presentation] BPSDを理由に精神科に入院した認知症患者の治療および転帰の実態2015
Author(s)
新井哲明, 池田学, 烏帽子田彰, 北村立, 松岡照之, 安野史彦, 横田修, 安部秀三, 栗田裕文, 畑中公孝, 田中芳郎, 大川恵子, 池嶋千秋, 太刀川弘和, 朝田隆
Organizer
第30回日本老年精神医学会,
Place of Presentation
横浜(パシフィコ横浜)
Year and Date
2015-06-13
Related Report
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[Presentation] うつ病における音声バイオマーカーの検討2015
Author(s)
田口高也, 太刀川弘和, 根本清貴, 鈴木雅之, 長野徹, 立花隆輝, 西村雅史, 新井哲明, 朝田隆
Organizer
第111回日本精神神経学会学術総会
Place of Presentation
大阪(大阪国際会議場・リーガロイヤルホテル大阪)
Year and Date
2015-06-06
Related Report
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[Presentation] 非定型タウオパチーの二剖検例2015
Author(s)
河上緒, 新井哲明, 池田研二, 大島健一, 新里和弘, 細川雅人, 長谷川成人, 秋山治彦
Organizer
第56回日本神経病理学会総会学術研究会
Place of Presentation
福岡(九州大学医学部百年講堂)
Year and Date
2015-06-05
Related Report
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