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Augmentation of cognitive behavioral therapy by visualization of brain function: NIRS-CBT study

Research Project

Project/Area Number 26461736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

Ono Tatsuro  群馬大学, 大学院医学系研究科, 助教 (40721014)

Co-Investigator(Kenkyū-buntansha) 福田 正人  群馬大学, 大学院医学系研究科, 教授 (20221533)
武井 雄一  群馬大学, 医学部附属病院, 講師 (30455985)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsNIRS / 認知行動療法
Outline of Final Research Achievements

In this study, we investigated the influence of cognitive behavioral therapy (CBT) to brain function longitudinally using a near infrared spectroscopy (NIRS) which can measure brain function easily and noninvasively. We aimed to establish a good biomarker that evaluate the effectiveness of CBT on panic disorder. We treated panic disorder patients with CBT including a total of 10 sessions, and measured NIRS during verbal fluency task and clinical evaluation before and treatment. Eight patients completed the measurement by March 2017. We analyzed oxygenated hemoglobin concentration changes of NIRS data before and after CBT using time-cluster analysis, and we found significant increased activations in the right superior temporal gyrus and inferior frontal gyrus after CBT. We showed that the NIRS can evaluate the effect of CBT on brain function of panic disorder. In the future, we want to promote the therapeutic effect of CBT on panic disorder by feedback of NIRS data.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results)

  • [Presentation] 認知行動療法のパニック障害への有効性の脳基盤についてのNIRS縦断研究2016

    • Author(s)
      小野樹郎,武井雄一,三浦あやか,草野建祐,林若穂,平野かほり,櫻井敬子,高嶺朋三,村山侑里,青山義之,成田耕介,福田正人
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] パニック障害患者における認知行動療法の効果:NIRSを用いた縦断的検討2015

    • Author(s)
      小野樹郎、武井雄一、三浦あやか、林若穂、平野かほり、櫻井敬子、高嶺朋三、村山侑里、青山義之、成田耕介、福田正人
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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