The investigation regarding physiological effects of insulin resistance on treatment resistant mood disorder

• Project/Area Number: 26461737
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: Narita Kosuke 群馬大学, 医学部附属病院, 講師 (70345677)
• Co-Investigator(Kenkyū-buntansha): 福田 正人 群馬大学, 大学院医学系研究科, 教授 (20221533)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 老年期精神障害 / 治療抵抗性気分障害 / 安静時脳MRI / 老年期気分障害 / インスリン抵抗性 / 脳MRI / 老年期うつ病

Outline of Final Research Achievements

The connectivity between Precuneus and Anterior Cingulate cortex in resting MRI were significantly associated with performance of risk taking in decision-making under risk condition in the elderlies. Then, resting MRI deta showed that power-law exponent obtained by fourier transformation was associated with reaction time.

Research Products

• [Int'l Joint Research] University of Ottawa(Canada)
• [Int'l Joint Research] Ottawa University/McGill University(Canada)
• [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults. (2016)
  • Author(s): Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
  • Journal Title: Molecular Autism Volume: 7 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s13229-016-0083-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Blood Transcriptomic Markers in Patients with Late-Onset Major Depressive Disorder. (2016)
  • Author(s): Miyata S, Kurachi M, Okano Y, Sakurai N, Kobayashi A, Harada K, Yamagata H, Matsuo K, Takahashi K, Narita K, Fukuda M, Ishizaki Y, Mikuni M.
  • Journal Title: PLoS One Volume: 11
• [Journal Article] Relationship of γ-aminobutyric acid and glutamate+glutamine concentrations in the perigenual anterior cingulate cortex with performance of Cambridge Gambling Task. (2015)
  • Author(s): Fujihara K, Narita K, Suzuki Y, Takei Y, Suda M, Tagawa M, Ujita K, Sakai Y, Narumoto J, Near J, Fukuda M.
  • Journal Title: Neuroimage Volume: 109 Pages: 102-8
  • DOI: 10.1016/j.neuroimage.2015.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Remarks] The Douglas Hospital Research Centre
  • URL: http://douglas.research.mcgill.ca/jamie-near