• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Brain structural changes associated with the onset of schizophrenia in individuals at risk for psychosis

Research Project

Project/Area Number 26461738
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

Takayanagi Yoichiro  富山大学, 附属病院, 講師 (40574942)

Co-Investigator(Kenkyū-buntansha) 鈴木 道雄  富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
高橋 努  富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
Co-Investigator(Renkei-kenkyūsha) MIZUNO Masafumi  東邦大学, 医学部, 教授 (80245589)
MATSUMOTO Kazunori  東北大学, 医学(系)研究科(研究院), 准教授 (40301056)
KASAI Kiyoto  東京大学, 医学部附属病院, 教授 (80322056)
Research Collaborator Ratnanather Tilak  Johns Hopkins University, Center for Imaging Sciences, Associate Professor
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords統合失調症 / at-risk mental state / 磁気共鳴画像(MRI) / ハイリスク / 発症予測 / バイオマーカー / 多施設研究 / MRI / 精神病発症危険状態 / 早期介入 / 脳形態
Outline of Final Research Achievements

We conducted a multi-site structural neuroimaging study of individuals at risk for developing psychosis to obtain a large sample size. Using labeled cortical distance mapping and local gyrification index, we found brain structural changes which predate the onset of frank psychosis such as cortical thinning of the anterior cingulate gyrus, gray matter reduction of the dorsolateral prefrontal cortex, and hypergyrification of the occipital cortex. These structural changes may be useful for predicting the future transition to psychosis such as schizophrenia.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Int'l Joint Research] Johns Hopkins University(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.2018

    • Author(s)
      Nakamura Mihoko, Takahashi Tsutomu, Takayanagi Yoichiro, Sasabayashi Daiki, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Koike Shinsuke, Yamasue Hidenori, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto , Suzuki Michio
    • Journal Title

      European Archives of Psychiatry and Clinical Neuroscience

      Volume: - Issue: 4 Pages: 397-406

    • DOI

      10.1007/s00406-018-0890-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced Thickness of the Anterior Cingulate Cortex in Individuals With an At-Risk Mental State Who Later Develop Psychosis.2017

    • Author(s)
      Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Obara C, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
    • Journal Title

      Schizophrenia Bulletin

      Volume: 43 Issue: 4 Pages: 907-913

    • DOI

      10.1093/schbul/sbw167

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Increased Occipital Gyrification and Development of Psychotic Disorders in Individuals With an At-Risk Mental State: A?Multicenter Study2017

    • Author(s)
      Sasabayashi Daiki, Takayanagi Yoichiro, Takahashi Tsutomu, Koike Shinsuke, Yamasue Hidenori, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Nakamura Mihoko, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto, Suzuki Michio
    • Journal Title

      Biological Psychiatry

      Volume: 82 Issue: 10 Pages: 737-745

    • DOI

      10.1016/j.biopsych.2017.05.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Prediction of transition to psychosis in individuals with ARMS using labeled cortical distance mapping and machine-learning methods.2017

    • Author(s)
      Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Obara C, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
    • Organizer
      2017 annual meeting of Organization for Human Brain Mapping
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] At-risk mental stateにおける大脳皮質下体積と側性の検討:多施設共同研究.2017

    • Author(s)
      笹林大樹, 高柳陽一郎, 高橋 努, 岡田直大, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 小原千佳, 中村美保子,古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
    • Organizer
      第21回日本精神保健・予防学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Increased brain cortical folding in individuals at risk of psychosis.2016

    • Author(s)
      Sasabayashi D, Takayanagi Y, Takahashi T, Koike S, Yamasue H, Katagiri N, Sakuma A, Obara C, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Kasai K, Suzuki M.
    • Organizer
      IEPA 10 Early Intervention in Mental Health
    • Place of Presentation
      Milano
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Altered thickness and surface area of the anterior cingulate cortex in individuals at high risk for psychosis.2016

    • Author(s)
      Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Obara C, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
    • Organizer
      IEPA 10 Early Intervention in Mental Health
    • Place of Presentation
      Milano
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] At-risk mental stateにおける脳回過形成.2016

    • Author(s)
      笹林大樹, 高柳陽一郎, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 中村美保子, 高橋 努, 古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
    • Organizer
      第38回日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 精神病発症リスク状態の脳形態画像:発症予測の可能性について2015

    • Author(s)
      高柳陽一郎
    • Organizer
      第19回日本精神保健・予防学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Labeled Cortical Distance Mappingを用いた、精神病発症高リスク群における前部帯状回と中前頭回の形態研究2015

    • Author(s)
      高柳 陽一郎, Kulason S, 笹林 大樹, 中村 美保子, 高橋 努, 古市 厚志, 木戸 幹雄, 西川 祐美子, 片桐 直之, 佐久間 篤, 松本 和紀, 水野 雅文, Ratnanather T, 鈴木 道雄
    • Organizer
      第37回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Cortical thickness changes in individuals at risk of psychosis2015

    • Author(s)
      Sasabayashi D, Takayanagi Y, Nakamura M, Takahashi T, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Koike S, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
    • Organizer
      29th European College of Neuropsychopharmacology (ECNP) Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cortical thickness changes in subjects at risk for developing psychosis2014

    • Author(s)
      Yoichiro Takayanagi, Daiki Sasabayashi, Mihoko Nakamura, Tsutomu Takahashi, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Naoyuki Katagiri, Atsushi Sakuma, Kazunori Matsumoto, Masafumi Mizuno, Michio Suzuki
    • Organizer
      The 9th International Conference on Early Psychosis
    • Place of Presentation
      東京
    • Year and Date
      2014-11-17 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] At-risk mental stateにおける大脳皮質厚の変化2014

    • Author(s)
      笹林大樹、高柳陽一郎、中村美保子、高橋努、古市厚志、木戸幹雄、西川裕美子、片桐直之、佐久間篤、松本和紀、水野雅文、鈴木道雄
    • Organizer
      第36回日本生物学的精神医学会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-06-07  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi