Brain structural changes associated with the onset of schizophrenia in individuals at risk for psychosis
Project/Area Number |
26461738
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | University of Toyama |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
鈴木 道雄 富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
高橋 努 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
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Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Masafumi 東邦大学, 医学部, 教授 (80245589)
MATSUMOTO Kazunori 東北大学, 医学(系)研究科(研究院), 准教授 (40301056)
KASAI Kiyoto 東京大学, 医学部附属病院, 教授 (80322056)
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Research Collaborator |
Ratnanather Tilak Johns Hopkins University, Center for Imaging Sciences, Associate Professor
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 統合失調症 / at-risk mental state / 磁気共鳴画像(MRI) / ハイリスク / 発症予測 / バイオマーカー / 多施設研究 / MRI / 精神病発症危険状態 / 早期介入 / 脳形態 |
Outline of Final Research Achievements |
We conducted a multi-site structural neuroimaging study of individuals at risk for developing psychosis to obtain a large sample size. Using labeled cortical distance mapping and local gyrification index, we found brain structural changes which predate the onset of frank psychosis such as cortical thinning of the anterior cingulate gyrus, gray matter reduction of the dorsolateral prefrontal cortex, and hypergyrification of the occipital cortex. These structural changes may be useful for predicting the future transition to psychosis such as schizophrenia.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study.2018
Author(s)
Nakamura Mihoko, Takahashi Tsutomu, Takayanagi Yoichiro, Sasabayashi Daiki, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Koike Shinsuke, Yamasue Hidenori, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto , Suzuki Michio
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Journal Title
European Archives of Psychiatry and Clinical Neuroscience
Volume: -
Issue: 4
Pages: 397-406
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reduced Thickness of the Anterior Cingulate Cortex in Individuals With an At-Risk Mental State Who Later Develop Psychosis.2017
Author(s)
Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Obara C, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
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Journal Title
Schizophrenia Bulletin
Volume: 43
Issue: 4
Pages: 907-913
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Increased Occipital Gyrification and Development of Psychotic Disorders in Individuals With an At-Risk Mental State: A?Multicenter Study2017
Author(s)
Sasabayashi Daiki, Takayanagi Yoichiro, Takahashi Tsutomu, Koike Shinsuke, Yamasue Hidenori, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Nakamura Mihoko, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto, Suzuki Michio
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Journal Title
Biological Psychiatry
Volume: 82
Issue: 10
Pages: 737-745
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Prediction of transition to psychosis in individuals with ARMS using labeled cortical distance mapping and machine-learning methods.2017
Author(s)
Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Obara C, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
Organizer
2017 annual meeting of Organization for Human Brain Mapping
Related Report
Int'l Joint Research
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[Presentation] At-risk mental stateにおける大脳皮質下体積と側性の検討:多施設共同研究.2017
Author(s)
笹林大樹, 高柳陽一郎, 高橋 努, 岡田直大, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 小原千佳, 中村美保子,古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
Organizer
第21回日本精神保健・予防学会学術集会
Related Report
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[Presentation] Increased brain cortical folding in individuals at risk of psychosis.2016
Author(s)
Sasabayashi D, Takayanagi Y, Takahashi T, Koike S, Yamasue H, Katagiri N, Sakuma A, Obara C, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Kasai K, Suzuki M.
Organizer
IEPA 10 Early Intervention in Mental Health
Place of Presentation
Milano
Year and Date
2016-10-20
Related Report
Int'l Joint Research
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[Presentation] Altered thickness and surface area of the anterior cingulate cortex in individuals at high risk for psychosis.2016
Author(s)
Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Obara C, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
Organizer
IEPA 10 Early Intervention in Mental Health
Place of Presentation
Milano
Year and Date
2016-10-20
Related Report
Int'l Joint Research
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[Presentation] At-risk mental stateにおける脳回過形成.2016
Author(s)
笹林大樹, 高柳陽一郎, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 中村美保子, 高橋 努, 古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
Organizer
第38回日本生物学的精神医学会
Place of Presentation
福岡
Year and Date
2016-09-08
Related Report
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[Presentation] Labeled Cortical Distance Mappingを用いた、精神病発症高リスク群における前部帯状回と中前頭回の形態研究2015
Author(s)
高柳 陽一郎, Kulason S, 笹林 大樹, 中村 美保子, 高橋 努, 古市 厚志, 木戸 幹雄, 西川 祐美子, 片桐 直之, 佐久間 篤, 松本 和紀, 水野 雅文, Ratnanather T, 鈴木 道雄
Organizer
第37回日本生物学的精神医学会
Place of Presentation
東京
Year and Date
2015-09-24
Related Report
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[Presentation] Cortical thickness changes in individuals at risk of psychosis2015
Author(s)
Sasabayashi D, Takayanagi Y, Nakamura M, Takahashi T, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Koike S, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
Organizer
29th European College of Neuropsychopharmacology (ECNP) Congress
Place of Presentation
Amsterdam
Year and Date
2015-08-29
Related Report
Int'l Joint Research
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[Presentation] Cortical thickness changes in subjects at risk for developing psychosis2014
Author(s)
Yoichiro Takayanagi, Daiki Sasabayashi, Mihoko Nakamura, Tsutomu Takahashi, Atsushi Furuichi, Mikio Kido, Yumiko Nishikawa, Naoyuki Katagiri, Atsushi Sakuma, Kazunori Matsumoto, Masafumi Mizuno, Michio Suzuki
Organizer
The 9th International Conference on Early Psychosis
Place of Presentation
東京
Year and Date
2014-11-17 – 2014-11-19
Related Report
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