Olfactory functioning and olfaction-related brain morphology in individuals with at-risk mental state

• Project/Area Number: 26461739
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Toyama
• Principal Investigator: Takahashi Tsutomu 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
• Co-Investigator(Kenkyū-buntansha): 鈴木 道雄 富山大学, 大学院医学薬学研究部(医学), 教授 (40236013) ; 高柳 陽一郎 富山大学, 附属病院, 講師 (40574942)
• Research Collaborator: Pantelis Christos
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / 精神病発症危険群 / 磁気共鳴画像 / 嗅覚 / 嗅溝 / 眼窩前頭皮質

Outline of Final Research Achievements

Both of individuals with at-risk mental state (ARMS) and patients with schizophrenia exhibited morphologic abnormalities in the depth of olfactory sulcus as well as olfactory deficits, which were partly associated with the severity of clinical symptoms and cognitive impairments. These findings could be biological markers of psychotic disorders that likely reflected early neurodevelopmental abnormalities.

Research Products

• [Int'l Joint Research] ジョンスホプキンス大学(アメリカ)
• [Journal Article] Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: Relationship with socio-cognitive functions and symptom severity. (2018)
  • Author(s): Takahashi Tsutomu、Nakamura Mihoko、Sasabayashi Daiki、Komori Yuko、Higuchi Yuko、Nishikawa Yumiko、Nishiyama Shimako、Itoh Hiroko、Masaoka Yuri、Suzuki Michio
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: 印刷中 Pages: 1-10
  • DOI: 10.1007/s00406-017-0845-3
  • Peer Reviewed
• [Journal Article] Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study (2018)
  • Author(s): Nakamura Mihoko, Takahashi Tsutomu, Takayanagi Yoichiro, Sasabayashi Daiki, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Koike Shinsuke, Yamasue Hidenori, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto , Suzuki Michio
  • Journal Title: Eur Arch Psychiatry Clin Neurosci Volume: -
  • DOI: 10.1007/s00406-018-0890-6
  • Peer Reviewed / Open Access
• [Journal Article] Brain neurodevelopmental markers related to the deficit subtype of schizophrenia (2017)
  • Author(s): Takahashi Tsutomu、Takayanagi Yoichiro、Nishikawa Yumiko、Nakamura Mihoko、Komori Yuko、Furuichi Atsushi、Kido Mikio、Sasabayashi Daiki、Noguchi Kyo、Suzuki Michio
  • Journal Title: Psychiatry Res Neuroimaging Volume: 266 Pages: 10-18
  • DOI: 10.1016/j.pscychresns.2017.05.007
  • Peer Reviewed
• [Journal Article] Reduced Thickness of the Anterior Cingulate Cortex in Individuals With an At-Risk Mental State Who Later Develop Psychosis (2017)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Obara C, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
  • Journal Title: Schizophr Bull Volume: 43 Pages: 907-913
  • DOI: 10.1093/schbul/sbw167
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased Occipital Gyrification and Development of Psychotic Disorders in Individuals With an At-Risk Mental State: A Multicenter Study. (2017)
  • Author(s): Sasabayashi Daiki, Takayanagi Yoichiro, Takahashi Tsutomu, Koike Shinsuke, Yamasue Hidenori, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Nakamura Mihoko, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto, Suzuki Michio
  • Journal Title: Biol Psychiatry Volume: 82 Pages: 737-745
  • DOI: 10.1016/j.biopsych.2017.05.018
  • Peer Reviewed
• [Journal Article] Olfactory sulcus morphology in patients with current and past major depression (2016)
  • Author(s): Takahashi T, Nishikawa Y, Yucel M, Whittle S, Lorenzetti V, Walterfang M, Daiki Sasabayashi, Suzuki M, Pantelis C, Allen NB.
  • Journal Title: Psychiatry Res Neuroimaging Volume: 255 Pages: 60-65
  • DOI: 10.1016/j.pscychresns.2016.07.008
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased number of orbital sulci in schizophrenia spectrum disorders. (2016)
  • Author(s): Takahashi T, Nakamura M, Nishikawa Y, Takayanagi Y, Furuichi A, Kido M, Sasabayashi D, Noguchi K, Suzuki M.
  • Journal Title: Psychiatry Research Neuroimaging Volume: 250 Pages: 29-32
  • DOI: 10.1016/j.pscychresns.2016.03.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Orbitofrontal sulcogyral pattern and olfactory sulcus depth in schizophrenia spectrum (2016)
  • Author(s): Nishikawa, Y.;Takahashi, T.;Takayanagi Y.;Furuichi, A.;Kido, M.;Nakamura, M.;Sasabayashi, D.;Noguchi, K.;Suzuki, M.
  • Journal Title: European Archives of Psychiatry and Clinical Neurosciences Volume: 266 Pages: 15-23
  • DOI: 10.1007/s00406-015-0587-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Possible relation between olfaction and anxiety in healthy subjects. (2015)
  • Author(s): Takahashi T, Itoh H, Nishikawa Y, Higuchi Y, Nakamura M, Sasabayashi D, Nishiyama S, Mizukami Y, Masaoka Y, Suzuki M.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 69 Pages: 431-438
  • DOI: 10.1111/pcn.12277
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects. (2015)
  • Author(s): Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: 56 Pages: 11-17
  • DOI: 10.1016/j.pnpbp.2014.07.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders (2014)
  • Author(s): Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yucel M, Phillips LJ, Nakamura Y, Suzuki M, Brewer WJ, Proffitt TM, McGorry PD, Velakoulis D, Pantelis C
  • Journal Title: Schizophr Res Volume: 153 Pages: 18-24
  • DOI: 10.1016/j.schres.2014.01.041
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Olfactory sulcus morphology in established bipolar affective disorder. (2014)
  • Author(s): Takahashi T,et al
  • Journal Title: Psychiatry Res Neuroimaging Volume: 222 Pages: 114-117
  • DOI: 10.1016/j.pscychresns.2014.02.005
  • Peer Reviewed
• [Presentation] MRI研究 (2018)
  • Author(s): 高橋 努
  • Organizer: 第13回日本統合失調症学会
  • Invited
• [Presentation] Deficit及びNon-deficit統合失調症における脳回形成の変化に関する研究 (2017)
  • Author(s): 2.高柳陽一郎, 笹林大樹, 高橋 努, 小森祐子, 古市厚志, 木戸幹雄, 西川祐美子, 中村美保子, 野口 京, 鈴木道雄
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] at-risk mental stateにおける大脳皮質下体積と側性の検討：多施設共同研究 (2017)
  • Author(s): 3.笹林大樹, 高柳陽一郎, 高橋 努, 岡田直大, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 小原千佳, 中村美保子,古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄
  • Organizer: 第21回日本精神保健・予防学会学術集会
• [Presentation] Prediction of transition to psychosis in individuals with ARMS using labeled cortical distance mapping and machine-learning methods (2017)
  • Author(s): 1)Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Obara C, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
  • Organizer: 2017 annual meeting of Organization for Human Brain Mapping
  • Int'l Joint Research
• [Presentation] 統合失調症およびAt-risk mental stateにおける嗅覚機能の障害 (2016)
  • Author(s): 高橋 努, 中村美保子, 笹林大樹, 西川祐美子, 樋口悠子, 小森祐子, 西山志満子, 伊藤博子, 鈴木道雄
  • Organizer: 第20回日本精神保健・予防学会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-12
• [Presentation] Olfactory Deficits in Individuals at Risk of Psychosis (2016)
  • Author(s): Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Higuchi Y, Komori Y, Nishiyama S, Itoh H, Suzuki M.
  • Organizer: IEPA 10 Early Intervention in Mental Health
  • Place of Presentation: Milano
  • Year and Date: 2016-10-20
  • Int'l Joint Research
• [Presentation] 統合失調症圏における眼窩前頭皮質の脳溝数減少 (2016)
  • Author(s): 高橋 努, 中村美保子, 西川祐美子, 高柳陽一郎, 古市厚志, 木戸幹雄, 笹林大樹, 野口京, 鈴木道雄
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] At-risk mental stateにおける嗅覚機能の障害 (2015)
  • Author(s): 高橋 努, 西川祐美子, 中村美保子, 笹林大樹, 樋口悠子, 水上祐子, 西山志満子, 伊藤博子, 鈴木道雄.
  • Organizer: 第19回日本精神保健・予防学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2015-12-12
• [Presentation] Progress in neuroimaging study for prodromal psychosis (2015)
  • Author(s): Takahashi T.
  • Organizer: WPA International Congress of Psychiatry
  • Place of Presentation: Taipei
  • Year and Date: 2015-11-18
  • Int'l Joint Research / Invited
• [Presentation] 統合失調症における嗅覚機能の障害 (2015)
  • Author(s): 高橋 努, 樋口悠子, 西川祐美子, 西山志満子, 水上祐子, 中村美保子, 笹林大樹, 伊藤博子, 鈴木道雄.
  • Organizer: 第10回日本統合失調症学会
  • Place of Presentation: 都市センターホテル（東京）
  • Year and Date: 2015-03-27 – 2015-03-28
• [Presentation] Brain morphologic changes during the course of schizophrenia (2014)
  • Author(s): Takahashi T, Suzuki M.
  • Organizer: 9th International Conference on Early Psychosis
  • Place of Presentation: Keio Plaza Hotel (Tokyo)
  • Year and Date: 2014-11-17 – 2014-11-19
  • Invited
• [Presentation] Altered depth of the olfactory sulcus in ultra high-risk individuals (2014)
  • Author(s): Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yucel M, Phillips LJ, Suzuki M, Brewer WJ, McGorry PD, Velakoulis D, Pantelis C.
  • Organizer: 9th International Conference on Early Psychosis
  • Place of Presentation: Keio Plaza Hotel (Tokyo)
  • Year and Date: 2014-11-17 – 2014-11-19
• [Presentation] Olfactory sulcus morphology in schizophrenia and established bipolar affective disorder (2014)
  • Author(s): Takahashi T, Nakamura Y, Malhi GS, Takayanagi Y, Furuichi A, Kido M, Noguchi K, Pantelis C, Suzuki M.
  • Organizer: 16th World Congress of Psychiatry
  • Place of Presentation: Madrid (Spain)
  • Year and Date: 2014-09-14 – 2014-09-18