Olfactory functioning and olfaction-related brain morphology in individuals with at-risk mental state
Project/Area Number |
26461739
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | University of Toyama |
Principal Investigator |
Takahashi Tsutomu 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
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Co-Investigator(Kenkyū-buntansha) |
鈴木 道雄 富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
高柳 陽一郎 富山大学, 附属病院, 講師 (40574942)
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Research Collaborator |
Pantelis Christos
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 統合失調症 / 精神病発症危険群 / 磁気共鳴画像 / 嗅覚 / 嗅溝 / 眼窩前頭皮質 |
Outline of Final Research Achievements |
Both of individuals with at-risk mental state (ARMS) and patients with schizophrenia exhibited morphologic abnormalities in the depth of olfactory sulcus as well as olfactory deficits, which were partly associated with the severity of clinical symptoms and cognitive impairments. These findings could be biological markers of psychotic disorders that likely reflected early neurodevelopmental abnormalities.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Potential role of orbitofrontal surface morphology on social and cognitive functions in high-risk subjects for psychosis and schizophrenia patients2019
Author(s)
akahashi, T., Nakamura, M., Sasabayashi, D., Komori, Y., Higuchi, Y., Nishikawa, Y., Nishiyama, S., Itoh, H., Masaoka, Y., Suzuki, M.
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Journal Title
Psychiatry Research: Neuroimaging
Volume: 25 October
Pages: 1-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study2018
Author(s)
Nakamura Mihoko, Takahashi Tsutomu, Takayanagi Yoichiro, Sasabayashi Daiki, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Koike Shinsuke, Yamasue Hidenori, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto , Suzuki Michio
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Journal Title
Eur Arch Psychiatry Clin Neurosci
Volume: -
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reduced Thickness of the Anterior Cingulate Cortex in Individuals With an At-Risk Mental State Who Later Develop Psychosis2017
Author(s)
Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Obara C, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M.
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Journal Title
Schizophr Bull
Volume: 43
Pages: 907-913
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Increased Occipital Gyrification and Development of Psychotic Disorders in Individuals With an At-Risk Mental State : A Multicenter Study2017
Author(s)
Sasabayashi D., Takayanagi Y., Takahashi T., Koike S., Yamasue H., Katagiri N., Sakuma A., Obara C., Nakamura M., Furuichi A., Kido M., Nishikawa Y., Noguchi K., Matsumoto K., Mizuno M., Kasai K., Suzuki M.
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Journal Title
Biological Psychiatry
Volume: 82
Pages: 737-745
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.2015
Author(s)
Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
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Journal Title
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume: 56
Pages: 11-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders2014
Author(s)
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yucel M, Phillips LJ, Nakamura Y, Suzuki M, Brewer WJ, Proffitt TM, McGorry PD, Velakoulis D, Pantelis C
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Journal Title
Schizophr Res
Volume: 153
Pages: 18-24
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] at-risk mental stateにおける大脳皮質下体積と側性の検討:多施設共同研究2017
Author(s)
3.笹林大樹, 高柳陽一郎, 高橋 努, 岡田直大, 小池進介, 山末英典, 片桐直之, 佐久間 篤, 小原千佳, 中村美保子,古市厚志, 木戸幹雄, 西川祐美子, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄
Organizer
第21回日本精神保健・予防学会学術集会
Related Report
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[Presentation] Prediction of transition to psychosis in individuals with ARMS using labeled cortical distance mapping and machine-learning methods2017
Author(s)
1)Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Katagiri N, Sakuma A, Obara C, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
Organizer
2017 annual meeting of Organization for Human Brain Mapping
Related Report
Int'l Joint Research
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[Presentation] 統合失調症圏における眼窩前頭皮質の脳溝数減少2016
Author(s)
高橋 努, 中村美保子, 西川祐美子, 高柳陽一郎, 古市厚志, 木戸幹雄, 笹林大樹, 野口京, 鈴木道雄
Organizer
第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
Place of Presentation
福岡
Year and Date
2016-09-08
Related Report
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[Presentation] 統合失調症における嗅覚機能の障害2015
Author(s)
高橋 努, 樋口悠子, 西川祐美子, 西山志満子, 水上祐子, 中村美保子, 笹林大樹, 伊藤博子, 鈴木道雄.
Organizer
第10回日本統合失調症学会
Place of Presentation
都市センターホテル(東京)
Year and Date
2015-03-27 – 2015-03-28
Related Report
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[Presentation] Altered depth of the olfactory sulcus in ultra high-risk individuals2014
Author(s)
Takahashi T, Wood SJ, Yung AR, Nelson B, Lin A, Yucel M, Phillips LJ, Suzuki M, Brewer WJ, McGorry PD, Velakoulis D, Pantelis C.
Organizer
9th International Conference on Early Psychosis
Place of Presentation
Keio Plaza Hotel (Tokyo)
Year and Date
2014-11-17 – 2014-11-19
Related Report
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