Assessment of neurophysiological changes with electroconvulsive therapy in mental disorders using nonlinear EEG approach

• Project/Area Number: 26461740
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: Okazaki Ryoko 福井大学, 学術研究院医学系部門(附属病院部), 助教 (90647778)
• Co-Investigator(Kenkyū-buntansha): 高橋 哲也 福井大学, 保健管理センター, 准教授 (00377459) ; 上野 幹二 福井大学, 学術研究院医学系部門, 特別研究員 (50600152)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 電気けいれん療法 / 神経ネットワーク / 脳波 / 非線形解析 / マルチスケールエントロピー解析 / うつ病 / 自閉スペクトラム症 / 強迫性障害 / 電機けいれん療法 / 自閉症スペクトラム障害

Outline of Final Research Achievements

Recently developed multiscale entropy analysis, which has underpinned aberrant functional connectivity in mental disorders, was introduced to explore changes in EEG complexity occurring with ECT in mental disorders.Depression patients demonstrated a decrease in EEG complexity, especially at higher frequencies. This decrease was associated with improvement of depressive symptoms. In ASD patient, along with ECT, the frontocentral region showed decreased EEG complexity, whereas the occipital region expressed an increase. Furthermore, these changes were associated with clinical improvement associated with the elevation of BDNF.
Multiscale entropy analysis might be a useful analytical method to elucidate neurophysiological mechanisms and evaluate the therapeutic efficacy of ECT in mental disorders.

Research Products

• [Journal Article] Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach. (2015)
  • Author(s): Okazaki R, Takahashi T*, Ueno K, Takahashi, Ishitobi M, Kikuchi M, Higashima M, Wada Y.
  • Journal Title: Front Hum Neurosci Volume: ９ Pages: 17-17
  • DOI: 10.3389/fnhum.2015.00106
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Assessment of neurophysiological changes with ECT in mental disorders using nonlinear approach (2015)
  • Author(s): Ryoko Okazaki
  • Organizer: World Psychiatric Association International Congress 2015
  • Place of Presentation: 台北
  • Year and Date: 2015-11-18
  • Int'l Joint Research