Prognostic biomarkers for conversion from MCI to dementia
Project/Area Number |
26461741
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | University of Yamanashi |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 老年精神医学 / うつ病 / 認知症 / アルツハイマー病 / 脳画像 / 酸化RNA / アミロイドβ / 電気けいれん療法 |
Outline of Final Research Achievements |
To investigate prognostic markers for conversion from MCI to dementia, we have focused on patients with late-life depression (LLD) who are at high risk of dementia. Higher plasma Aβ40 was associated with higher degree of parahippocampal atrophy and lower verbal fluency performance. The LLD patients were divided into 3 groups according to their cognitive status before and after the treatment, i.e., (i) cognitively normal subjects, (ii) the MCI reverters to normal cognition, and (iii) MCI-non-reverters. Remarkably, we found higher plasma Aβ40 levels and lower verbal fluency performance at baseline in the MCI-non-reverters who were at highest risk of dementia compared with the other 2 groups. Because these alterations were not significantly found in amnestic MCI without depression, plasma Aβ40 and verbal fluency performance may function as prognostic markers for conversion from MCI to dementia specifically in LLD patients. Serum oxidized RNA did not function as a prognostic marker.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Accumulation of intraneuronal amyloid-β is common in normal brain2014
Author(s)
Blair JA, Siedlak S, Wolfram J, Nunomura A, Castellani R, Ferreira S, Klein W, Wang Y, Casadesus G, Smith M, Perry G, Zhu X, Lee H
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Journal Title
Current Alzheimer Research
Volume: 11
Issue: 4
Pages: 317-324
DOI
Related Report
Peer Reviewed
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[Presentation] せん妄:診断・予防・治療2016
Author(s)
布村 明彦
Organizer
第34回日本神経治療学会
Place of Presentation
米子コンベンションセンター、鳥取県米子市
Year and Date
2016-11-03
Related Report
Invited
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[Presentation] ストレス適応と認知症予防2016
Author(s)
布村明彦
Organizer
第16回日本抗加齢医学会総会
Place of Presentation
パシフィコ横浜(神奈川 県・横浜市)
Year and Date
2016-06-10
Related Report
Invited
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[Presentation] RNA酸化傷害と変性性認知症2014
Author(s)
布村明彦、玉置寿男
Organizer
第33回日本認知症学会学術集会
Place of Presentation
パシフィコ横浜、横浜市
Year and Date
2014-11-29 – 2014-12-01
Related Report
Invited
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[Presentation] ストレスと認知症2014
Author(s)
布村明彦
Organizer
第14回日本抗加齢医学会総会
Place of Presentation
大阪国際会議場、大阪市
Year and Date
2014-06-06 – 2014-06-08
Related Report
Invited
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