| Project/Area Number |
26461743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyoto University |
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Principal Investigator |
Suwa Taro 京都大学, 医学研究科, 助教 (10518153)
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| Co-Investigator(Kenkyū-buntansha) |
麻生 俊彦 京都大学, 医学研究科, 特定講師 (50397543)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYATA Jun 京都大学, 医学研究科, 講師 (90549099)
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| Research Collaborator |
YAMASAKI Shimpei 京都大学, 医学研究科, 大学院生
SUGIHARA Genichi 京都大学, 医学研究科, 院内講師
MATSUMOTO Yukiko 京都大学, 医学研究科, 助教
MISHIMA Ryo 京都大学, 医学研究科, 大学院生
FUJIMOTO Gaku 京都大学, 医学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 緊張病 / 緊張病症候群 / 電気けいれん療法 / ECT / カタトニア / 局所糖代謝 / restingfMRI / 脳機能画像データ収集 / 心理検査データ収集 |
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| Outline of Final Research Achievements |
We recruited 7 schizophrenia patients with catatonia. In all cases, catatonic symptoms disappeared after treatment, 5 cases were treated with ECT, and 2 cases with medication. The change in cerebral glucose metabolism was evaluated before and after treatment using [18F]-fluorodeoxyglucose positron emission tomography.
Comparisons between before and after treatment metabolic activity revealed increased regional metabolism in both sides of the lingual gyrus and the left precuneus after treatment. This result may suggest that the visual processing and the somatosensory system were impaired in the catatonic state and improved after treatment. These finding are the first in the world and it is a beneficial discovery for clarifying the biological basis of catatonia.
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