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Clarification of the progress mechanism of REM sleep behavior disorder to Lewy body disease using connectivity analysis

Research Project

Project/Area Number 26461744
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

ADACHI HIROYOSHI  大阪大学, 保健センター, 准教授 (00303785)

Co-Investigator(Kenkyū-buntansha) 渡邉 嘉之  大阪大学, 医学系研究科, 准教授 (20362733)
数井 裕光  大阪大学, 医学系研究科, 講師 (30346217)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords睡眠 / 認知症 / 睡眠時随伴症 / 頭部MRI / 睡眠医学
Outline of Final Research Achievements

In this study, in order to elucidate the pathology mainly of Dementia of Lewy body disease and Parkinson's disease and elucidate its neurodegenerative process, patients with idiopathic REM sleep behavior disorder who were before onset of neurodegenerative diseases were included, prospectively. As a result of comprehensive examination of neurophysiological evaluation, cognitive function evaluation, and brain image analysis, no subject of RBD showed the progression to neurodegenerative diseases. This is thought that the period that can be tracked during this research is as short as less than 3 years. In the future study, it is thought that it is necessary to increase the number of cases and lead to comprehensive research with longer follow-up period.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (2 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] 睡眠時随伴症 高齢者の睡眠障害2015

    • Author(s)
      足立浩祥
    • Journal Title

      日本臨床

      Volume: 73 Pages: 949-953

    • Related Report
      2015 Research-status Report
  • [Journal Article] 睡眠障害の臨床 睡眠時随伴症群-ノンレム睡眠覚醒障害-2014

    • Author(s)
      足立浩祥
    • Journal Title

      臨床精神医学

      Volume: 43 Pages: 1013-1018

    • Related Report
      2014 Research-status Report
  • [Presentation] 睡眠時随伴症2016

    • Author(s)
      足立浩祥
    • Organizer
      第29回日本サイコオンコロジー学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 睡眠障害の視点からみたBPSDの予防と介入2016

    • Author(s)
      足立浩祥
    • Organizer
      第31回日本老年精神医学会
    • Place of Presentation
      金沢歌劇座(石川県金沢市)
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知症の原因疾患別による進行度と睡眠の問題との関連2014

    • Author(s)
      足立浩祥、壁下康信、松下正輝、三上章良、野々上茂、中内緑、重土好古、数井裕光
    • Organizer
      第6回日本臨床睡眠医学会
    • Place of Presentation
      神戸市
    • Year and Date
      2014-08-01 – 2014-08-03
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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