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A prospective study for biomakers that predict incident dementia: the Imari study

Research Project

Project/Area Number 26461749
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionSaga University

Principal Investigator

Kawashima Toshiro  佐賀大学, 医学部, 客員研究員 (90325605)

Co-Investigator(Kenkyū-buntansha) 門司 晃  佐賀大学, 医学部, 教授 (00294942)
國武 裕  佐賀大学, 医学部, 助教 (30404148)
溝口 義人  佐賀大学, 医学部, 准教授 (60467892)
Research Collaborator WATANABE Itaru  
IMAMURA Yoshiomi  
MATSUSHIMA Jun  
NABETA Hiromi  
YAMAMOTO Hiroshi  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords高齢者 / 認知機能 / 抑うつ / 頭部MRI / 可溶性インターロイキン-2受容体 / オキシトシン / 認知症 / 頭部MRI / サイトカイン
Outline of Final Research Achievements

In the previous surveys, we have collected serum samples of healthy elderly residents in Kurokawa region in Saga prefecture (the Imari Study). In the present project, we measured blood concentrations of various inflammatory markers and oxytocin. We analyzed the relationship between each obtained biochemical marker and depression, cognitive function, view on death and life.
In the cross-sectional analyses, there was a positive correlation between soluble interleukin-2 receptor and cognitive function only in males. In the sequential evaluation, we could not find any relation to depression status or cognitive function for any inflammatory markers. We also found that serum oxytocin negatively correlated with the intensity of view of the afterlife.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] An association between belief in life after death and serum oxytocin in older people in rural Japan2017

    • Author(s)
      Imamura Yoshiomi、Mizoguchi Yoshito、Nabeta Hiromi、Haraguchi Yoshinori、Matsushima Jun、Kojima Naoki、Kawashima Toshiro、Yamada Shigeto、Monji Akira
    • Journal Title

      International Journal of Geriatric Psychiatry

      Volume: 32 Issue: 1 Pages: 102-109

    • DOI

      10.1002/gps.4453

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.2015

    • Author(s)
      Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.
    • Journal Title

      Psychiatr Genet.

      Volume: 25(4) Issue: 4 Pages: 139-146

    • DOI

      10.1097/ypg.0000000000000090

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: a 3-year follow-up study.2015

    • Author(s)
      Matsushima J, Kawashima T, Nabeta H, Imamura Y, Watanabe I, Mizoguchi Y, Kojima N, Yamada S, Monji A.
    • Journal Title

      J Affect Disord

      Volume: 173 Pages: 9-14

    • DOI

      10.1016/j.jad.2014.10.030

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 高齢者における宗教性と生化学的指標との関連2016

    • Author(s)
      今村 義臣、溝口 義人、鍋田 紘美、原口 祥典、松島 淳、川島 敏郎、小島直 樹、山田 茂人、門司 晃
    • Organizer
      第31回日本老年精神医学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 高齢者のうつ症状と生理学的指標との関連についての検討2016

    • Author(s)
      鍋田 紘美、今村 義臣、溝口 義人、原口 祥典、松島 淳、小島 直樹、山田 茂人、門司 晃
    • Organizer
      第31回日本老年精神医学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2016-06-23
    • Related Report
      2016 Research-status Report
  • [Remarks] 佐賀大学医学部精神医学講座

    • URL

      http://saga-psychiatry.kir.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究紹介 佐賀大学医学部精神医学講座

    • URL

      http://saga-psychiatry.kir.jp/research/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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