Investigation for the neural basis of apathy in dementia
Project/Area Number |
26461750
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
|
Research Institution | Osaka University (2016) Kumamoto University (2014-2015) |
Principal Investigator |
Ikeda Manabu 大阪大学, 医学系研究科, 教授 (60284395)
|
Co-Investigator(Kenkyū-buntansha) |
橋本 衛 熊本大学, 大学院生命科学研究部(医), 准教授 (20452881)
平井 俊範 宮崎大学, 医学部, 教授 (40274724)
福原 竜治 熊本大学, 医学部附属病院, 講師 (60346682)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | アパシー / 神経基盤 / 前頭側頭型認知症 / 意味性認知症 / アルツハイマー病 / MRI / SPECT / アルツハイマー型認知症 |
Outline of Final Research Achievements |
We gathered Neuropsychiatric Inventory (NPI) data of patients with Alzheimer’s disease (AD; n = 1091), dementia with Lewy bodies (DLB; n = 249), vascular dementia (VaD; n = 156), and frontotemporal lobar degeneration (FTLD; n = 102). The progression of dementia was significantly associated with the severity of apathy in AD, DLB and VaD patients. However, trajectories of apathy in FTLD were unclear. Apathy was the most prevalent BPSD in AD, DLB, VaD, FTLD patients with almost all CDR stages.
|
Report
(4 results)
Research Products
(66 results)
-
-
-
-
[Journal Article] Differences of Behavioral and Psychological Symptoms of Dementia in Disease Severity in Four Major Dementias2016
Author(s)
Kazui H, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Hashimoto M, Ikeda M, Tanaka H, Hatada Y, Matsushita M, Nishio Y, Mori E, Tanimukai S, Komori K, Yoshida T, Shimizu H, Matsumoto T, Mori T, Kashibayashi T, Yokoyama K, Shimomura T, Kabeshita Y, Adachi H, Tanaka T
-
Journal Title
PLoS One
Volume: 11
Issue: 8
Pages: e0161092-e0161092
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Malnutrition in Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal lobar degeneration: comparison using serum albumin, total protein, and hemoglobin level2016
Author(s)
Koyama A, Hashimoto M, Tanaka H, Fujise N, Matsushita M, Miyagawa Y, Hatada Y, Fukuhara R, Hasegawa N, Todani S, Matsukuma K, Kawano M, Ikeda M
-
Journal Title
PLoS One
Volume: 11
Issue: 6
Pages: e0157053-e0157053
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] The pareidolia test: a simple neuropsychological test measuring visual hallucination-like illusions2016
Author(s)
Yasuyuki Mamiya, Yoshiyuki Nishio, Hiroyuki Watanabe, Kayoko Yokoi, Makoto Uchiyama, Toru Baba, Osamu Iizuka, Shigenori Kanno, Naoto Kamimura, Hiroaki Kazui, Mamoru Hashimoto, Manabu Ikeda, Chieko Takeshita, Tatsuo Shimomura, Etsuro Mori
-
Journal Title
PloS one
Volume: 11
Issue: 5
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Sleep disturbances are key symptoms of very early stage Alzheimer disease with behavioral and psychological symptoms: a Japan multi-center cross-sectional study (J-BIRD).2016
Author(s)
Kabeshita Y, Adachi H, Matsushita M, Kanemoto H, Sato S, Suzuki Y, Yoshiyama K, Shimomura T, Yoshida T, Shimizu H, Matsumoto T, Mori T, Kashibayashi T, Tanaka H, Hatada Y, Hashimoto M, Nishio Y, Komori K, Tanaka T, Yokoyama K, Tanimukai S, Ikeda M, Takeda M, Mori E, Kudo T, Kazui H.
-
Journal Title
Int J Geriatr Psychiatry.
Volume: -
Issue: 2
Pages: 222-230
DOI
Related Report
Peer Reviewed
-
[Journal Article] Diagnostic significance of cortical superficial siderosis for Alzheimer’s disease in patients with cognitive impairment.2016
Author(s)
Inoue Y, Nakajima M, Uetani H, Hirai T, Ueda M, Kitajima M, Utsunomiya D, Watanabe M, Hashimoto M, Ikeda M, Yamashita Y, Ando Y.
-
Journal Title
AJNR Am J Neuroradiol
Volume: 37
Issue: 2
Pages: 223-227
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Relationship between dementia severity and behavioral and psychological symptoms of dementia in dementia with Lewy bodies and Alzheimer’s disease patients2015
Author(s)
Hashimoto M, Ogawa Y, Yatabe Y, Ishikawa T, Fukuhara R, Kaneda K, Honda K, Yuki S, Imamura T, Ksazui H, Kamimura N, Shinagawa S, Mizukami K, Mori E, Ikeda M
-
Journal Title
Dement Geriatr Cogn Disord Extra
Volume: 5
Issue: 2
Pages: 244-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Relationship between dementia severity and behavioural and psychological symptoms in early-onset Alzheimer's disease.2015
Author(s)
Tanaka H, Hashimoto M, Fukuhara R, Ishikawa T, Yatabe Y, Kaneda K, Yuuki S, Honda K, Matsuzaki S, Tsuyuguchi A, Hatada Y, Ikeda M.
-
Journal Title
Psychogeriatrics
Volume: -
Issue: 4
Pages: 242-7
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Integrated Care in Dementia2016
Author(s)
Ikeda M
Organizer
The National Forum of Integrated Care in Dementia, Chang Gung Memorial Hospital,
Place of Presentation
Taoyuan/China
Related Report
Int'l Joint Research / Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-