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Biomarkers predict the occurrence of BPSD

Research Project

Project/Area Number 26461751
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Miyazaki

Principal Investigator

Hayashi Yoshihito  宮崎大学, 医学部, 准教授 (20295223)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords認知症 / バイオマーカー / BPSD / 介護負担 / 介護うつ / 唾液 / コルチゾール / メラトニン
Outline of Final Research Achievements

Current Japan is super aged society, and a major problem to face is increase of the number of dementia. The cause that the patients are refused to be stayed at home is occurrence of BPSD. A cerebral pathologic change and the stress consisting of environmental factors influence BPSD. Therefore we must predict the occurrence of BPSD to care them immediately. This time, I could take in vivo biomarkers (cortisol, melatonin in saliva) and evaluate psychological symptoms and cognitive functions at the same time every three months for a year. Result: I knew that some apparent changes might occur when I checked each hormone level before big change of psychological symptoms appeared. Therefore, I thought that I might predict a symptom change by seeing changes of the biomarkers. I think that these methods lead to improvement of the quality of life of the patient and the reduction of the burden on caregiver.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] 認知症の行動・心理症状に対する薬物療法の注意点─抑肝散の可能性─2017

    • Author(s)
      石田康,林要人,宇田川充隆,岡原一徳
    • Journal Title

      臨床と研究

      Volume: 94 (1) Pages: 134-137

    • Related Report
      2016 Annual Research Report
  • [Journal Article] An Open-label trial of Yokukansan on Sleep Disturbance in Alzheimer's disease and other Dementia2015

    • Author(s)
      Y.Hayashi,Y.Ishida,K.Okahara ,Y.Mitsuyama
    • Journal Title

      J.Prev Alzheimer Dis

      Volume: 2(3) Pages: 172-177

    • DOI

      10.14283/jpad.2015.70

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] レビー小体型認知症患者に対する抑肝散投与の有用性 長期投与の有効性および安全性に関する後方視的観察研究2014

    • Author(s)
      岡原 一徳, 石田 康, 林 要人, 土屋 利紀
    • Journal Title

      Dementia Japan

      Volume: 28 Pages: 97-107

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] An open label study to investigate the effects of a traditional Japanese medicine, yokukansan, on the sleep disturbances in patients with Alzheimer’s disease and other dementia2014

    • Author(s)
      Yoshihito Hayashi, Yasushi Ishida, Kazunori Okahara, Yoshio Mitsuyama
    • Organizer
      Clinical Trials on Alzheimer's Disease (CTAD)
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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