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Neuroimaging research of compulsivity

Research Project

Project/Area Number 26461753
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Fukui Kenji  京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (50165263)

Co-Investigator(Kenkyū-buntansha) 中前 貴  京都府立医科大学, 医学(系)研究科(研究院), 助教 (50542891)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsインターネット依存 / 強迫性
Outline of Final Research Achievements

This is a neuroimaging research that investigated psychiatric illness with compulsivity. We found abnormalities of front-striatal connectivity in patients with obsessive-compulsive disorder, and white matter abnormalities in the fornix in patients with anorexia nervosa.
We also conducted questionnaire survey to investigate the prevalence of problematic internet use among adult psychiatric patients. Of our 231 respondents, 58 (25.1%) were defined as problematic internet users. The prevalence of problematic internet use among adult psychiatric patients is relatively higher than that of general population (6%). The age of problematic internet users was significantly lower than that of normal internet users. The problematic internet users scored significantly higher on scales measuring various psychiatric symptoms including obsessive-compulsive symptom.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] VU University/University of Amsterdam(オランダ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Bellvitge University(スペイン)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Cambridge(英国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis2017

    • Author(s)
      Boedhoe PS, Nakamae T, 他
    • Journal Title

      Am J Psychiatry

      Volume: 174 Issue: 1 Pages: 60-70

    • DOI

      10.1176/appi.ajp.2016.16020201

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Brain circuitry of compulsivity.2015

    • Author(s)
      van den Heuvel OA, van Wingen G, Soriano-Mas C, Alonso P, Chamberlain SR, Nakamae T, Denys D, Goudriaan AE, Veltman DJ.
    • Journal Title

      Eur Neuropsychopharmacol.

      Volume: in press Issue: 5 Pages: 810-827

    • DOI

      10.1016/j.euroneuro.2015.12.005

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hyper-influence of the orbitofrontal cortex over the ventral striatum in obsessive-compulsive disorder.2015

    • Author(s)
      Abe Y, Sakai Y, Nishida S, Nakamae T, Yamada K, Fukui K, Narumoto J.
    • Journal Title

      Eur Neuropsychopharmacol.

      Volume: 25 Issue: 11 Pages: 1898-1905

    • DOI

      10.1016/j.euroneuro.2015.08.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered Fronto-Striatal Fiber Topography and Connectivity in Obsessive-Compulsive Disorder2014

    • Author(s)
      Takashi Nakamae, Yuki Sakai, Yoshinari Abe, Seiji Nishida, Kenji Fukui, Kei Yamada, Manabu Kubota, Damiaan Denys, Jin Narumoto
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 11 Pages: e112075-e112075

    • DOI

      10.1371/journal.pone.0112075

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A tract-based spatial statistics study in anorexia nervosa : abnormality in the fornix and the cerebellum2014

    • Author(s)
      Nagahara Y, Fukui K(他10人)
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 51 Pages: 72-7

    • DOI

      10.1016/j.pnpbp.2014.01.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] アルコール依存症の長期予後.特集:精神障害の長期予後.2014

    • Author(s)
      西村伊三男,福居顯二.
    • Journal Title

      臨床精神医学

      Volume: 43 Pages: 1409-1413

    • NAID

      40020222962

    • Related Report
      2014 Research-status Report
  • [Presentation] Age-specific subcortical volumetric abnormalities in obsessive-compulsive disorder (OCD): Findings from the ENIGMA-OCD working group2016

    • Author(s)
      Boedhoe PSW, Nakamae T, 他
    • Organizer
      22nd Annual Meeting of the Organization on Human Brain Mapping
    • Place of Presentation
      Geneva
    • Year and Date
      2016-06-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Altered frontostriatal connectivity in obsessive-compulsive disorder.2015

    • Author(s)
      Nakamae T.
    • Organizer
      12th World Congress of Biological Psychiatry
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural Link between Obsessive-Compulsive Disorder and Delay Discounting.2014

    • Author(s)
      Yu Takagi, Yuki Sakai, Seiji Nishida, Takashi Nakamae, Jin Narumoto, Kei Yamada, Kenji Fukui, Saori C Tanaka.
    • Organizer
      日本神経回路学会第24回全国大会
    • Place of Presentation
      公立はこだて未来大学(函館)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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