• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of the default mode network by simultaneous measurement of functional MRI and EEG.

Research Project

Project/Area Number 26461757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionJuntendo University

Principal Investigator

Eiji Kirino  順天堂大学, 医学部, 教授 (90276460)

Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsrs-fMRI / LORETA / schizophrenia / EEG / functional connectivity / defDefault mode network / 皮質線条体ネットワーク / 同時計測 / default mode network / salience network / sLORETA / fMRI / fMRI / autism spectrum disorder / functional MRI / 統合失調症 / Functional Connectivity
Outline of Final Research Achievements

This study focused on the functional connectivity (FC) of the cortico-striatal network, which is thought to be disrupted in schizophrenia and to contribute to its clinical manifestations. We used simultaneous resting-state functional MRI (rsfMRI) and electroencephalography (EEG) recordings to investigate FC in patients with schizophrenia.
Compared to HCs, patients with schizophrenia showed enhanced FC between the caudate nucleus and the posterior cingulate cortex, temporal and occipital regions on rsfMRI. It is thus possible that HCs have negative FC between these regions, whereas patients with schizophrenia have non-negative FC. Patients showed trends of local over-connectivity/global underconnectivity in EEG.
Increased FC in the caudate may represent aberrant between-network FC resulting from the disruption of segregation between networks. These findings may reflect aberrant between-network connectivity that results from disruption of segregation between networks.

Academic Significance and Societal Importance of the Research Achievements

統合失調症の病態にfunctional connectivity (FC)の異常が大きく関わっていることが報告されているが、依然一定の見解は得られていない。最も研究されている脳内ネットワークの一つであるdefault mode network (DMN)に関しても、統合失調症に関する所見は一定ではない。fMRI・脳波・拡散MRIの同時測定はそれぞれの手法の持つ利点を最大に生かせる組み合わせである。fMRI・脳波によるfunctionalなモデルに拡散MRIによる解剖学的なモデルを融合することが可能となる。これらの同時測定による統合失調症患者FCの検討は国際的にも例を見ない。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (56 results)

All 2019 2018 2017 2016 2015 2014

All Journal Article (29 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 21 results,  Open Access: 12 results,  Acknowledgement Compliant: 2 results) Presentation (25 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Book (2 results)

  • [Journal Article] Nicotine effect on mismatch negativity in smoking and nonsmoking patients with schizophrenia2019

    • Author(s)
      Inami Rie、Kirino Eiji
    • Journal Title

      Schizophrenia Research

      Volume: - Pages: 496-497

    • DOI

      10.1016/j.schres.2019.01.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Functional Connectivity of the Angular Gyrus During Imagined Music Performance2019

    • Author(s)
      Tanaka Shoji、Kirino Eiji
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 13 Pages: 92-92

    • DOI

      10.3389/fnhum.2019.00092

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision2019

    • Author(s)
      Kirino Eiji
    • Journal Title

      Psychogeriatrics

      Volume: - Issue: 1 Pages: 118-123

    • DOI

      10.1111/psyg.12455

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous fMRI-EEG-DTI Recording of MMN in patients with schizophrenia.2019

    • Author(s)
      Kirino E, Hayakawa Y, Inami R, Inoue R, Aoki S
    • Journal Title

      PLoS One.

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 統合失調症とDefault Mode Network2019

    • Author(s)
      桐野衛二
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 210-211

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 成人自閉症スペクトラム障害患者におけるfunctional connectivityのrs-fMRIを用いた検討2019

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,新井平伊,井上令一
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 統合失調症のfunctional connectivityのrs-fMRI・脳波同時計測を用いた検討.2019

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,新井平伊,井上令一
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Functional Connectivity of the Caudate in Schizophrenia Evaluated with Simultaneous Resting-State Functional MRI and Electroencephalography Recordings2018

    • Author(s)
      Kirino Eiji、Tanaka Shoji、Fukuta Mayuko、Inami Rie、Inoue Reiichi、Aoki Shigeki
    • Journal Title

      Neuropsychobiology

      Volume: 77 Issue: 4 Pages: 165-175

    • DOI

      10.1159/000490429

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機能的MRIと脳波の安静時同時記録による統合失調症患者の脳内機能的連絡の検討.2018

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,新井平伊,井上令一,青木茂樹
    • Journal Title

      精神神経学雑誌

      Volume: 120 Pages: 990-996

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Reorganization of the thalamocortical network in musicians2017

    • Author(s)
      Tanaka S, Kirino E.
    • Journal Title

      Brain Research

      Volume: 1664 Pages: 48-54

    • DOI

      10.1016/j.brainres.2017.03.027

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional stereotactic surface projection in the statistical analysis of SPECT data for distinguishing between Alzheimer’s disease and depression.2017

    • Author(s)
      Kirino E
    • Journal Title

      World Journal of Psychiatry

      Volume: 7 Issue: 2 Pages: 121-127

    • DOI

      10.5498/wjp.v7.i2.121

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.2017

    • Author(s)
      Kirino E
    • Journal Title

      Annals of General Psychiatry

      Volume: 16 Issue: 1 Pages: 43-43

    • DOI

      10.1186/s12991-017-0166-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic Reconfiguration of the Supplementary Motor Area Network during Imagined Music Performance2017

    • Author(s)
      Shoji Tanaka, Eiji Kirino
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 11 Pages: 1-11

    • DOI

      10.3389/fnhum.2017.00606

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 統合失調症におけるdefault mode networkのfMRIと脳波の同時計測を用いた検討.2017

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,井上令一,新井平伊
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 17 Pages: 33-41

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous fMRI and EEG Recordings of Functional Connectivity in Patients with Schizophrenia2017

    • Author(s)
      Kirino E.Tanaka S,Fukuta M,Inami R,Arai H,Inoue R,Aoki S
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: 71 Issue: 4 Pages: 262-270

    • DOI

      10.1111/pcn.12495

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of topiramate in Japanese patients with binge eating behavior2017

    • Author(s)
      Kirino E.
    • Journal Title

      Current Topics in Pharmacology.

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Journal Article] Three-dimensional stereotactic surface projection in the statistical analysis of SPECT data for distinguishing between Alzheimer’s disease and depression2017

    • Author(s)
      Kirino E.
    • Journal Title

      World Journal of Psychiatry

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 統合失調症におけるdefault mode networkのfMRIと脳波の同時計測を用いた検討2017

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,井上令一,新井平伊
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
  • [Journal Article] Functional connectivity of the dorsal striatum in female musicians.2016

    • Author(s)
      Tanaka S, Kirino E
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 10 Pages: 1-9

    • DOI

      10.3389/fnhum.2016.00178

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional connectivity of the precuneus in female university students with long-term musical training.2016

    • Author(s)
      Tanaka S, Kirino E
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 10 Pages: 1-7

    • DOI

      10.3389/fnhum.2016.00328

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] うつ病とアルツハイマー病の鑑別におけるSPECT 3D-SSPおよびDAT-SPECTの有用性について2016

    • Author(s)
      桐野 衛二:
    • Journal Title

      総合病院精神医学

      Volume: 28 Pages: 233-242

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 統合失調症におけるdefault mode networkのfMRIと脳波の同時計測を用いた検討2016

    • Author(s)
      .桐野衛二,田中昌司,福田麻由子,稲見理絵,井上令一,新井平伊
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 17

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] うつ病とアルツハイマー病の鑑別におけるSPECT 3D-SSPおよびDAT-SPECTの有用性について2016

    • Author(s)
      桐野 衛二
    • Journal Title

      総合病院精神医学

      Volume: 28

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A voxel-based morphometry study of the brain of university students majoring in music and non-music disciplines2015

    • Author(s)
      Sato K, Kirino E, Tanaka S
    • Journal Title

      Behavioural Neurology

      Volume: 2015 Pages: 1-9

    • DOI

      10.1155/2015/274919

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional organization of resting-state networks in young healthy adults.2015

    • Author(s)
      Tanaka S, Fukuta M, Inami R, Kirino E, Inoue R, Arai H
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 16 Pages: 5-16

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A voxel-based morphometry study of the brains of university students majoring in music and in other non-music disciplines2015

    • Author(s)
      Sato K, Kirino E, Tanaka S
    • Journal Title

      Behavioural Neurology

      Volume: 2015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Innate Cognitive Style and Mind Reading among Japanese University Students: An approach from Empathizing-Systemizing Theory.2015

    • Author(s)
      Kawata Y, Hirosawa M, Hirotsu N, Kirino E
    • Journal Title

      Juntendo Medical Journal

      Volume: 60

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 安静時脳ネットワークの機能的構造2015

    • Author(s)
      田中昌司,福田麻由子,稲見理絵,桐野衛二,井上令一,新井平伊
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 15

    • Related Report
      2014 Research-status Report
  • [Journal Article] 精神科領域におけるdefault mode network2014

    • Author(s)
      桐野 衛二,田中 昌司
    • Journal Title

      神経内科

      Volume: 81 Pages: 189-195

    • Related Report
      2014 Research-status Report
  • [Presentation] 自閉症スペクトラム障害のDiffusional Kurtosis Imagingによる予備的研究2018

    • Author(s)
      服部亜紀,鎌形康司,桐野衛二,武中祐樹,倉持麻奈,クリスティーナ・アンディカ,堀正明,青木茂樹
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functional network for the planning of music performance.2018

    • Author(s)
      田中昌司,桐野衛二
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 統合失調症の皮質線条体ネットワークのrs-fMRI・脳波同時計測を用いた検討2018

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,新井平伊,井上令一
    • Organizer
      第21回日本薬物脳波学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 総合病院で一般精神科医が診るADHD.2018

    • Author(s)
      桐野衛二
    • Organizer
      第31回日本総合病院精神医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A network for auditory-motor coupling: comparison between musicians and nonmusicians2017

    • Author(s)
      Tanaka S, Kirino E
    • Organizer
      Annual Meeting of The Cognitive Neuroscience Society
    • Place of Presentation
      San Francisco
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症のfunctional connectivityのrs-fMRI・脳波同時計測を用いた検討.2017

    • Author(s)
      桐野衛二,田中昌司,福田麻由子,稲見理絵,新井平伊,井上令一
    • Organizer
      .第20回日本薬物脳波学会学術集会 シンポジウム 「脳波の臨床応用の可能性について」
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 成人自閉症スペクトラム障害患者におけるfunctional connectivityのrs-fMRIを用いた検討2016

    • Author(s)
      82.桐野衛二,田中昌司,福田麻由子,稲見理絵,新井平伊,井上令一
    • Organizer
      第18回日本薬物脳波学会学術集会
    • Place of Presentation
      宮古島
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
  • [Presentation] コーディネーション能力と社会認知能力および言語能力との関連性2016

    • Author(s)
      望月明人, 須藤路子, 伊藤憲治, 桐野衛二
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 顔の表情知覚における機能的脳神経ネットワークの動的再構成2016

    • Author(s)
      高木宏章, 桐野衛二, 田中昌司
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 音大生の脳は喫前部の機能的結合が強化されている2016

    • Author(s)
      田中昌司, 桐野衛二
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] fMRI・脳波同時計測による統合失調症患者のMMNの検討2015

    • Author(s)
      桐野衛二
    • Organizer
      第45回日本臨床神経生理学会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Networks for the perception of dynamic facial expressions2015

    • Author(s)
      Hasegawa K, Kirino E, Tanaka S
    • Organizer
      神経科学学会
    • Place of Presentation
      神戸 神戸国際会議場
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] A VBM study of the brains of music-majored students and non-music-majored students2015

    • Author(s)
      Sato K, Kirino E, Tanaka S
    • Organizer
      神経科学学会
    • Place of Presentation
      神戸 神戸国際会議場
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional connectivity in the brains of music majored students and non-music majored students2015

    • Author(s)
      Tanaka S, Sato K, Kirino E
    • Organizer
      神経科学学会
    • Place of Presentation
      神戸 神戸国際会議場
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional connectivity in the brains of music majored students and non-music majored students.2015

    • Author(s)
      Tanaka S, Sato K, Kirino E
    • Organizer
      神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Networks for the perception of dynamic facial expressions2015

    • Author(s)
      Hasegawa K, Kirino E, Tanaka S
    • Organizer
      神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] A VBM study of the brains of music-majored students and non-music-majored student2015

    • Author(s)
      Sato K, Kirino E, Tanaka S
    • Organizer
      神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 統合失調症患者におけるdefault mode networkのfMRIと脳波の同時計測を用いた検討2015

    • Author(s)
      桐野衛二,田中昌二,福田麻由子,稲見理絵,井上令一,新井平伊
    • Organizer
      第18回日本薬物脳波学会学術集会,
    • Place of Presentation
      和歌山
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Networks for the perception of dynamic facial expressions2015

    • Author(s)
      Hasegawa K, Kirino E, Tanaka S
    • Organizer
      Organization of Human Brain Mapping Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A VBM study of the brains of music-majored students and non-music-majored students2015

    • Author(s)
      Sato K, Kirino E, Tanaka S
    • Organizer
      Organization of Human Brain Mapping Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional connectivity in the brains of music majored students and non-music majored students.2015

    • Author(s)
      Tanaka S, Sato K, Kirino E
    • Organizer
      Organization of Human Brain Mapping Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ワーキングメモリと社会コミュニケーション機能―fMRI研究―2014

    • Author(s)
      桐野衛二
    • Organizer
      第44回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡 福岡国際会議場
    • Year and Date
      2014-11-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Simultaneous fMRI-EEG-DTI recording of MMN in schizophrenia2014

    • Author(s)
      Kirino E, Hayakawa Y, Inoue R, Aoki S, Arai H
    • Organizer
      17th World Congress of Psychophysiology
    • Place of Presentation
      広島 広島国際会議場
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Function からConnectivityへ-fMRI・脳波・拡散テンソルイメージング同時計測による認知機能の検討-2014

    • Author(s)
      桐野衛二
    • Organizer
      第17回日本薬物脳波学会学術集会
    • Place of Presentation
      静岡 長泉山荘
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] fMRIを用いたマインド・リーディングの神経基盤の解明-EmpathizingとSystemizingの認知スタイルに着目して-2014

    • Author(s)
      川田裕次郎,桐野衛二,広沢正孝
    • Organizer
      第17回日本薬物脳波学会学術集会
    • Place of Presentation
      静岡 長泉山荘
    • Year and Date
      2014-06-13
    • Related Report
      2014 Research-status Report
  • [Book] 日本臨床神経生理学会 専門医・専門技術師 試験問題解説1202018

    • Author(s)
      日本臨床神経生理学会(今井富裕 他 編集 桐野衛二 他共同執筆)
    • Total Pages
      192
    • Publisher
      診断と治療社
    • ISBN
      9784787823779
    • Related Report
      2018 Annual Research Report
  • [Book] カプラン臨床精神医学テキストDSM-5診断基準の臨床への展開 日本語版第3版/原著第11版2016

    • Author(s)
      井上令一(監修),四宮滋子,田宮聡(監訳),桐野衛二(監訳協力)
    • Total Pages
      1672
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi