| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study focused on the functional connectivity (FC) of the cortico-striatal network, which is thought to be disrupted in schizophrenia and to contribute to its clinical manifestations. We used simultaneous resting-state functional MRI (rsfMRI) and electroencephalography (EEG) recordings to investigate FC in patients with schizophrenia.
Compared to HCs, patients with schizophrenia showed enhanced FC between the caudate nucleus and the posterior cingulate cortex, temporal and occipital regions on rsfMRI. It is thus possible that HCs have negative FC between these regions, whereas patients with schizophrenia have non-negative FC. Patients showed trends of local over-connectivity/global underconnectivity in EEG.
Increased FC in the caudate may represent aberrant between-network FC resulting from the disruption of segregation between networks. These findings may reflect aberrant between-network connectivity that results from disruption of segregation between networks.
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