Development of biomarkers showing care burden of families with dementia people and family intervention program
| Project/Area Number |
26461758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
Maeda Kiyoshi 神戸学院大学, 総合リハビリテーション学部, 教授 (80116251)
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| Co-Investigator(Kenkyū-buntansha) |
川又 敏男 神戸大学, 保健学研究科, 教授 (70214690)
阪井 一雄 宝塚医療大学, 保健医療学部, 教授 (80304096)
山本 泰司 神戸大学, 保健管理センター, 准教授 (00324921)
梶田 博之 神戸学院大学, 総合リハビリテーション学部, 助教 (00441197)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 認知症 / 家族介護者 / 介護負担 / 家族介入プログラム / ヒトヘルペスウイルス / バイオマーカー / 疲労 / ストレス / ヒトヘルペスウィルス |
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| Outline of Final Research Achievements |
We examined chronic fatigue in family caregivers for people with dementia. Forty-four family caregivers (CG) and 50 elderly control (NCG) participated in this study. We measured salivary human herpesvirus (HHV)-6 and -7 DNA levels and CFS to assess levels of fatigue; we also measured CES-D, Physical Activity Scale for the Elderly, ZBI etc.
For CG, HHV-6 DNA levels and CFS scores were significantly higher than those in NCG. HHV-6 DNA levels in CG were significantly correlated with depressive symptoms, the cognitive function of the patients, and ADL/IADL of the patients. The CFS scores in CG significantly correlated with caregiver burden, depression symptoms, leisure physical activity and the number of other family caregivers.
HHV-6 DNA levels may be added as a new biomarker for caregiver exhaustion. We concluded that fatigue assessments should be performed by not only a questionnaire, but also by a biomarker search, such as HHV-6.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Prediction of outcomes in MCI by using 18F-FDG-PET: A multicenter study,2015
Author(s)
Kengo Ito, Hidenao Fukuyama, Michio Senda, Kazunari Ishii, Kiyoshi Maeda, Yasushi Yamamoto, Yasuomi Ouchi, Kenji Ishii, Ayumu Okumura, Ken Fijiwara, Takashi Kato, Yutaka Arahata, Yukihiko Washimi, Yoshio Mitsuyama, Kenichi Meguro, Mitsuru Ikeda,
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Journal Title
J Alzheimer’s Disease
Volume: 45
Pages: 543-552
Related Report
Peer Reviewed / Open Access
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[Presentation] レビー小体型認知症の精神症状2014
Author(s)
小田陽彦，前田潔
Organizer
第110回日本精神神経学会
Place of Presentation
パシフィコ横浜（神奈川県）
Year and Date
2014-06-26 – 2014-06-28
Related Report
Invited
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