The exploration for key imaging molecules relating to brain accumulation of Vitronectin in the mouse model of Tauopathy

• Project/Area Number: 26461760
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima (2015-2016); National Institute of Radiological Sciences (2014)
• Principal Investigator: MARUYAMA Masahiro 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (80396481)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ビトロネクチン / タウオパチー / 膜侵襲複合体 / 脳萎縮 / ビトロネクチン受容体 / 新生神経突起伸長 / シナプス再構築 / 活性化ミクログリア

Outline of Final Research Achievements

A final component of complement system, the membrane attack complex（MAC）, affects neuronal dissolution which leads to brain atrophy in the mouse model of tauopathy. MAC acted as a raiding factor by contrast with the vitronectin(Vn) for tau crumbling neuron. The serious atrophy at hippocampus made by such mechanism in the Vn deleted model of tauopathy. It seems that the modulation of Vn-complement system controls the pathology in the tauopathy.

Research Products

• [Journal Article] タウ封入体イメージング開発におけるモデルマウス実験を通じて見えてきたもの (2016)
  • Author(s): 丸山将浩、樋口真人
  • Journal Title: 日本認知症学会誌 Volume: 30 Pages: 303-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Elucidation of molecular mechanism on the dementia through In vivo model animal imaging (2016)
  • Author(s): Maruyama masahiro, Makoto Higuchi
  • Journal Title: Dementia Japan Volume: 30
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of tau pathology in living mouse model and human tauopathies including Alzheimer’s disease (2015)
  • Author(s): Masahiro Maruyama, Hitoshi Shimada, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
  • Journal Title: NIRS Annual Report Volume: 2013-2014 Pages: 46-7
  • Peer Reviewed / Open Access
• [Presentation] タウ封入体イメージング開発における モデルマウス実験を通じて見えてきたもの (2015)
  • Author(s): 丸山 将浩
  • Organizer: 第34回 日本認知症学会 学術集会
  • Place of Presentation: 青森市 リンクステーションホール青森・ホテル青森
  • Year and Date: 2015-10-02
• [Presentation] The 2014 de Leon Prize in Neuroimaging (2014)
  • Author(s): Masahiro Maruyama, Hitoshi Shimada
  • Organizer: Alzheimer's Imaging Consortium (AAIC)
  • Place of Presentation: Copenhagen
  • Year and Date: 2014-07-12
  • Invited