Effect of transcranial direct current stimulation on cognitive function in schizophrenia

• Project/Area Number: 26461761
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Sumiyoshi Tomiki 国立研究開発法人国立精神・神経医療研究センター, トランスレーショナル・メディカルセンター, 部長 (80286062)
• Co-Investigator(Kenkyū-buntansha): 中込 和幸 国立研究開発法人国立精神・神経医療研究センター, その他部局等, 所長 (30198056)
• Co-Investigator(Renkei-kenkyūsha): OKAZAKI Mitsutoshi 国立研究開発法人国立精神・神経医療研究センター, 病院, 診療部長 (50568756) ; NODA Takamasa 国立研究開発法人国立精神・神経医療研究センター, 病院, 医長 (50446572) ; TAKAEDA Kazuyoshi 国立研究開発法人国立精神・神経医療研究センター, 病院, 医師 (00631342)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ニューロモデュレーション / 経頭蓋直流刺激 / 統合失調症 / 認知機能障害 / 認知機能 / 脳機能計測 / 日常生活技能

Outline of Final Research Achievements

This study investigated the effect of transcranial direct current stimulation on cognitive function in schizophrenia. Subjects were patients with schizophrenia who consented to participate in the study that was approved by Ethical Committee of NCNP. A tDCS apparatus of Soterix Medical Co.Ltd was used to stimulate the brain through electrodes place on left and right frontal cortex for 20 min, twice daily for 5 days. Cognition and psychotic symptoms were assessed before the stimulation and one month after the last stimulation. Repeated administration of tDCS was found to alleviate cognitive disturbances of patients with schizophrenia.

Research Products

• [Journal Article] Associations between daily living skills, cognition, and real-world functioning across stages of schizophrenia; A study with the Schizophrenia Cognition Rating Scale Japanese version. (2017)
  • Author(s): Higuchi Y, Sumiyoshi T, Seo T, Suga M, Takahashia T, Nishiyama S, Komori Y, Kasai K, Suzuki M
  • Journal Title: Schizophrenia Research Cognition Volume: 7 Pages: 13-18
  • DOI: 10.1016/j.scog.2017.01.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Successful Treatment of Psychomotor Agitation in Neuromyelitis Optica Spectrum Disorder with Trazodone-Risperidone Combination: A Case Report (2017)
  • Author(s): Narita Z, Takano H, Sumiyoshi T.
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 13 Pages: 775-777
  • DOI: 10.2147/ndt.s132516
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive insight and functional outcome in schizophrenia; A multi-center collaborative study with the Specific Level of Functioning Scale - Japanese version. (2016)
  • Author(s): Sumiyoshi T., Nishida K, Niimura H, Toyomaki A, Morimoto T, Tani M, Inada K, Ninomiya T, Hori H, Manabe J, Katsuki A, Kubo T, Koshikawa Y, Shirahama M, Kohno K, Kinoshita T, Kusumi I, Iwanami A, Ueno T, Kishimoto T, Terao T, Nakagome K
  • Journal Title: Schizophrenia Research Cognition Volume: 6 Pages: 9-14
  • DOI: 10.1016/j.scog.2016.08.001
  • Peer Reviewed / Open Access
• [Journal Article] Decreased DNA methylation in the Shati/Nat8l promoter in both patients with schizophrenia and a methamphetamine-induced murine model of schizophrenia-like phenotype (2016)
  • Author(s): Uno K, Kikuchi Y, Iwata M, Uehara T, Matsuoka T, Sumiyoshi T, Okamoto Y, Jinno H, Takada T, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A
  • Journal Title: PLoS One Volume: 11 Issue: 6 Pages: e0157959-e0157959
  • DOI: 10.1371/journal.pone.0157959
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. (2016)
  • Author(s): Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R.
  • Journal Title: Psychiatry Res Volume: 245 Pages: 371-378
  • DOI: 10.1016/j.psychres.2016.08.018
  • Peer Reviewed / Open Access
• [Journal Article] Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives (2015)
  • Author(s): Yuma Yokoi and Tomiki Sumiyoshi
  • Journal Title: Neuropsychiatric Electrophysiology Volume: 1:10 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s40810-015-0012-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Facial expression perception correlates with verbal working memory function in schizophrenia (2015)
  • Author(s): Kumiko Hagiya, Tomiki Sumiyoshi, Ayako Kanie, Shenghong Pu, Koichi Kaneko, Tamiko Mogami, Sachie Oshima, Niwa, Akiko Inagaki,Emi Ikebuchi, Akiko Kikuchi, Syudo Yamasaki, Kazuhiko Iwata, and Kazuyuki Nakagome
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 69(12) Issue: 12 Pages: 773-781
  • DOI: 10.1111/pcn.12329
  • Peer Reviewed
• [Journal Article] Functional outcome in patients with schizophrenia: the concept and the measurement. (2015)
  • Author(s): Sumiyoshi C., Sumiyoshi T.
  • Journal Title: Activitas Nervosa Superior Volume: 57 Pages: 1-11
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels (2015)
  • Author(s): Chika Sumiyoshi, Philip D. Harvey, Manabu Takaki, Yuko Okahisa, Taku Sato, Ichiro Sora, Keith H. Nuechterlein, Kenneth L.. Subotnik, Tomiki Sumiyoshi
  • Journal Title: Schizophrenia Research: Cognition Volume: 2 Issue: 3 Pages: 105-112
  • DOI: 10.1016/j.scog.2015.07.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Predicting employment status and subjective quality of life in patients with schizophrenia. (2015)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
  • Journal Title: Schizophrenia Research: Cognition Volume: 3 Pages: 20-25
  • DOI: 10.1016/j.scog.2015.10.005
  • Peer Reviewed / Open Access
• [Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia. (2014)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
  • Journal Title: Psychiatry Clin Neurosci. Volume: in press Issue: 7 Pages: 534-541
  • DOI: 10.1111/pcn.12165
  • Peer Reviewed
• [Journal Article] Does sleep improve memory organization? (2014)
  • Author(s): Takeuchi M, Furuta H, Sumiyoshi T, Suzuki M, Ochiai Y, Hosokawa M, Matsui M, Kurachi M
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 8 Pages: 65-65
  • DOI: 10.3389/fnbeh.2014.00065
  • Peer Reviewed / Open Access
• [Journal Article] Mismatch negativity and P3a/reorienting complex in subjects with schizophrenia or at-risk mental state. (2014)
  • Author(s): Higuchi Y, Seo T, Miyanishi T, Kawasaki Y, Suzuki M, Sumiyoshi T
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 8 Pages: 172-172
  • DOI: 10.3389/fnbeh.2014.00172
  • Peer Reviewed / Open Access
• [Journal Article] Utility of the UCSD performance-based Skills Assessment-brief Japanese version: discriminative ability and relation to neurocognition (2014)
  • Author(s): 112. Sumiyoshi C., Takaki M., A., Okahisa Y., Patterson T. L., Harvey P.D, Sumiyoshi T.
  • Journal Title: Schizophrenia Research Cognition Volume: 1 Pages: 137-143
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serotonin and dopamine receptor in motivational and cognitive disturbances of schizophrenia. (2014)
  • Author(s): Sumiyoshi T., Kunugi H., Nakagome K
  • Journal Title: Frontiers in Neuroscience Volume: 8
  • DOI: 10.3389/fnins.2014.00395
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Cognitive insight and real-world functional outcome in schizophrenia (2016)
  • Author(s): Sumiyoshi T.
  • Organizer: Cognition in Schizophrenia 2016
  • Place of Presentation: Florence
  • Int'l Joint Research / Invited
• [Presentation] 精神疾患における認知機能障害の評価：社会機能との関連 (2016)
  • Author(s): 住吉太幹、中込和幸、池澤 聰、住吉チカ
  • Organizer: 第46回日本神経精神薬理学会
  • Place of Presentation: ソウル
  • Invited
• [Presentation] Emotional perception deficits in schizophrenia; Implications for antipsyochotic treatments. (2015)
  • Author(s): Sumiyoshi T
  • Organizer: WPA International Congress 2015
  • Place of Presentation: Ｔａｉｐｅｉ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｃｏｎｖｅｎｔｉｏｎ Ｃｅｎｔｅｒ，Taipei
  • Int'l Joint Research / Invited
• [Presentation] 統合失調症の認知機能評価バッテリー：臨床研究・開発への応用 (2015)
  • Author(s): 住吉太幹
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 京王プラザホテル，東京
  • Invited
• [Presentation] LORETA current source density for duration mismatch negativity in early schizophrenia and at-risk mental state (2015)
  • Author(s): Sumiyoshi T., Miyanishi T., Seo T., Suzuki M., Higuchi Y.
  • Organizer: Annual Joint Meeting of ECNS/ISNIP/ISBET 2015
  • Place of Presentation: Munchen University, Munich
  • Int'l Joint Research
• [Presentation] LORETA current source density for duration mismatch negativity in early schizophrenia and at-risk mental state (2015)
  • Author(s): 住吉太幹、宮西知広、樋口悠子
  • Organizer: 第45回日本臨床神経生理学会
  • Place of Presentation: 京王プラザホテル, 東京
  • Invited
• [Presentation] Feasibility and efficacy study of Social Cognition and Interaction Training (SCIT) in Japan; a multicenter randomized clical trial – Interm report- (2015)
  • Author(s): 93. Kanie A., Nakagome K., Ikezawa S., Kikuchi A., Hagiya K., Ashida S., Ozawa S., Sumiyoshi T., Haga D., Tanaka Y., Ishida A, Nemoto T., Fukuoka T., Takazawa S., Matsuda Y., Morimoto T., Iwata K., Ikebuchi E, Roberts D. L.
  • Organizer: Cognitive Remediation in Psychiatry
  • Place of Presentation: Ｔｈｅ Ｃｏｎｆｅｒｅｎｃｅ Ｃｅｎｔｅｒ，New York
  • Int'l Joint Research
• [Book] 精神医学症候群(第2版) (2017)
  • Author(s): 末吉一貴、住吉太幹
  • Total Pages: 4
  • Publisher: 日本臨床社
• [Book] 統合失調症のベストプラクティス (2016)
  • Author(s): 住吉チカ、住吉太幹
  • Total Pages: 4
  • Publisher: 星和書店
• [Book] Cognitive Enhancement (2015)
  • Author(s): Sumiyoshi T
  • Total Pages: 470
  • Publisher: Springer
• [Remarks] 統合失調症の認知機能障害に対する経頭蓋直流電気刺激の効果に関する研究
  • URL: http://www.ncnp.go.jp/hospital/edics/dl/doc-8.pdf