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Effect of transcranial direct current stimulation on cognitive function in schizophrenia

Research Project

Project/Area Number 26461761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Sumiyoshi Tomiki  国立研究開発法人国立精神・神経医療研究センター, トランスレーショナル・メディカルセンター, 部長 (80286062)

Co-Investigator(Kenkyū-buntansha) 中込 和幸  国立研究開発法人国立精神・神経医療研究センター, その他部局等, 所長 (30198056)
Co-Investigator(Renkei-kenkyūsha) OKAZAKI Mitsutoshi  国立研究開発法人国立精神・神経医療研究センター, 病院, 診療部長 (50568756)
NODA Takamasa  国立研究開発法人国立精神・神経医療研究センター, 病院, 医長 (50446572)
TAKAEDA Kazuyoshi  国立研究開発法人国立精神・神経医療研究センター, 病院, 医師 (00631342)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsニューロモデュレーション / 経頭蓋直流刺激 / 統合失調症 / 認知機能障害 / 認知機能 / 脳機能計測 / 日常生活技能
Outline of Final Research Achievements

This study investigated the effect of transcranial direct current stimulation on cognitive function in schizophrenia. Subjects were patients with schizophrenia who consented to participate in the study that was approved by Ethical Committee of NCNP. A tDCS apparatus of Soterix Medical Co.Ltd was used to stimulate the brain through electrodes place on left and right frontal cortex for 20 min, twice daily for 5 days. Cognition and psychotic symptoms were assessed before the stimulation and one month after the last stimulation. Repeated administration of tDCS was found to alleviate cognitive disturbances of patients with schizophrenia.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 2014 Other

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 12 results,  Acknowledgement Compliant: 7 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Associations between daily living skills, cognition, and real-world functioning across stages of schizophrenia; A study with the Schizophrenia Cognition Rating Scale Japanese version.2017

    • Author(s)
      Higuchi Y, Sumiyoshi T, Seo T, Suga M, Takahashia T, Nishiyama S, Komori Y, Kasai K, Suzuki M
    • Journal Title

      Schizophrenia Research Cognition

      Volume: 7 Pages: 13-18

    • DOI

      10.1016/j.scog.2017.01.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Successful Treatment of Psychomotor Agitation in Neuromyelitis Optica Spectrum Disorder with Trazodone-Risperidone Combination: A Case Report2017

    • Author(s)
      Narita Z, Takano H, Sumiyoshi T.
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 13 Pages: 775-777

    • DOI

      10.2147/ndt.s132516

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive insight and functional outcome in schizophrenia; A multi-center collaborative study with the Specific Level of Functioning Scale - Japanese version.2016

    • Author(s)
      Sumiyoshi T., Nishida K, Niimura H, Toyomaki A, Morimoto T, Tani M, Inada K, Ninomiya T, Hori H, Manabe J, Katsuki A, Kubo T, Koshikawa Y, Shirahama M, Kohno K, Kinoshita T, Kusumi I, Iwanami A, Ueno T, Kishimoto T, Terao T, Nakagome K
    • Journal Title

      Schizophrenia Research Cognition

      Volume: 6 Pages: 9-14

    • DOI

      10.1016/j.scog.2016.08.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased DNA methylation in the Shati/Nat8l promoter in both patients with schizophrenia and a methamphetamine-induced murine model of schizophrenia-like phenotype2016

    • Author(s)
      Uno K, Kikuchi Y, Iwata M, Uehara T, Matsuoka T, Sumiyoshi T, Okamoto Y, Jinno H, Takada T, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A
    • Journal Title

      PLoS One

      Volume: 11 Issue: 6 Pages: e0157959-e0157959

    • DOI

      10.1371/journal.pone.0157959

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia.2016

    • Author(s)
      Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R.
    • Journal Title

      Psychiatry Res

      Volume: 245 Pages: 371-378

    • DOI

      10.1016/j.psychres.2016.08.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives2015

    • Author(s)
      Yuma Yokoi and Tomiki Sumiyoshi
    • Journal Title

      Neuropsychiatric Electrophysiology

      Volume: 1:10 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s40810-015-0012-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Facial expression perception correlates with verbal working memory function in schizophrenia2015

    • Author(s)
      Kumiko Hagiya, Tomiki Sumiyoshi, Ayako Kanie, Shenghong Pu, Koichi Kaneko, Tamiko Mogami, Sachie Oshima, Niwa, Akiko Inagaki,Emi Ikebuchi, Akiko Kikuchi, Syudo Yamasaki, Kazuhiko Iwata, and Kazuyuki Nakagome
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 69(12) Issue: 12 Pages: 773-781

    • DOI

      10.1111/pcn.12329

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional outcome in patients with schizophrenia: the concept and the measurement.2015

    • Author(s)
      Sumiyoshi C., Sumiyoshi T.
    • Journal Title

      Activitas Nervosa Superior

      Volume: 57 Pages: 1-11

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Factors predicting work outcome in Japanese patients with schizophrenia: role of multiple functioning levels2015

    • Author(s)
      Chika Sumiyoshi, Philip D. Harvey, Manabu Takaki, Yuko Okahisa, Taku Sato, Ichiro Sora, Keith H. Nuechterlein, Kenneth L.. Subotnik, Tomiki Sumiyoshi
    • Journal Title

      Schizophrenia Research: Cognition

      Volume: 2 Issue: 3 Pages: 105-112

    • DOI

      10.1016/j.scog.2015.07.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Predicting employment status and subjective quality of life in patients with schizophrenia.2015

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
    • Journal Title

      Schizophrenia Research: Cognition

      Volume: 3 Pages: 20-25

    • DOI

      10.1016/j.scog.2015.10.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia.2014

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: in press Issue: 7 Pages: 534-541

    • DOI

      10.1111/pcn.12165

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Does sleep improve memory organization?2014

    • Author(s)
      Takeuchi M, Furuta H, Sumiyoshi T, Suzuki M, Ochiai Y, Hosokawa M, Matsui M, Kurachi M
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 8 Pages: 65-65

    • DOI

      10.3389/fnbeh.2014.00065

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mismatch negativity and P3a/reorienting complex in subjects with schizophrenia or at-risk mental state.2014

    • Author(s)
      Higuchi Y, Seo T, Miyanishi T, Kawasaki Y, Suzuki M, Sumiyoshi T
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 8 Pages: 172-172

    • DOI

      10.3389/fnbeh.2014.00172

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of the UCSD performance-based Skills Assessment-brief Japanese version: discriminative ability and relation to neurocognition2014

    • Author(s)
      112. Sumiyoshi C., Takaki M., A., Okahisa Y., Patterson T. L., Harvey P.D, Sumiyoshi T.
    • Journal Title

      Schizophrenia Research Cognition

      Volume: 1 Pages: 137-143

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serotonin and dopamine receptors in motivational and cognitive disturbances of schizophrenia2014

    • Author(s)
      Sumiyoshi T., Kunugi H., Nakagome K
    • Journal Title

      Frontiers in Neuroscience

      Volume: 8 Issue: DEC

    • DOI

      10.3389/fnins.2014.00395

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Cognitive insight and real-world functional outcome in schizophrenia2016

    • Author(s)
      Sumiyoshi T.
    • Organizer
      Cognition in Schizophrenia 2016
    • Place of Presentation
      Florence
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 精神疾患における認知機能障害の評価:社会機能との関連2016

    • Author(s)
      住吉太幹、中込和幸、池澤 聰、住吉チカ
    • Organizer
      第46回日本神経精神薬理学会
    • Place of Presentation
      ソウル
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Emotional perception deficits in schizophrenia; Implications for antipsyochotic treatments.2015

    • Author(s)
      Sumiyoshi T
    • Organizer
      WPA International Congress 2015
    • Place of Presentation
      Taipei International Convention Center,Taipei
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 統合失調症の認知機能評価バッテリー:臨床研究・開発への応用2015

    • Author(s)
      住吉太幹
    • Organizer
      第25回日本臨床精神神経薬理学会
    • Place of Presentation
      京王プラザホテル,東京
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] LORETA current source density for duration mismatch negativity in early schizophrenia and at-risk mental state2015

    • Author(s)
      Sumiyoshi T., Miyanishi T., Seo T., Suzuki M., Higuchi Y.
    • Organizer
      Annual Joint Meeting of ECNS/ISNIP/ISBET 2015
    • Place of Presentation
      Munchen University, Munich
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] LORETA current source density for duration mismatch negativity in early schizophrenia and at-risk mental state2015

    • Author(s)
      住吉太幹、宮西知広、樋口悠子
    • Organizer
      第45回日本臨床神経生理学会
    • Place of Presentation
      京王プラザホテル, 東京
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Feasibility and efficacy study of Social Cognition and Interaction Training (SCIT) in Japan; a multicenter randomized clical trial – Interm report-2015

    • Author(s)
      93. Kanie A., Nakagome K., Ikezawa S., Kikuchi A., Hagiya K., Ashida S., Ozawa S., Sumiyoshi T., Haga D., Tanaka Y., Ishida A, Nemoto T., Fukuoka T., Takazawa S., Matsuda Y., Morimoto T., Iwata K., Ikebuchi E, Roberts D. L.
    • Organizer
      Cognitive Remediation in Psychiatry
    • Place of Presentation
      The Conference Center,New York
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 精神医学症候群(第2版)2017

    • Author(s)
      末吉一貴、住吉太幹
    • Total Pages
      4
    • Publisher
      日本臨床社
    • Related Report
      2016 Annual Research Report
  • [Book] 統合失調症のベストプラクティス2016

    • Author(s)
      住吉チカ、住吉太幹
    • Total Pages
      4
    • Publisher
      星和書店
    • Related Report
      2016 Annual Research Report
  • [Book] Cognitive Enhancement2015

    • Author(s)
      Sumiyoshi T
    • Total Pages
      470
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Remarks] 統合失調症の認知機能障害に対する経頭蓋直流電気刺激の効果に関する研究

    • URL

      http://www.ncnp.go.jp/hospital/edics/dl/doc-8.pdf

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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