A Structual MRI and MRS Study on Brain Function of Child and Adolescent Obsessive-Compulsive and Autism Spectrum Disorder
| Project/Area Number |
26461762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Chiba University |
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Principal Investigator |
NAKAGAWA AKIKO 千葉大学, 子どものこころの発達教育研究センター, 特任教授 (70253424)
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| Co-Investigator(Kenkyū-buntansha) |
富安 もよこ 千葉大学, 子どものこころの発達教育研究センター, 特任講師 (10443079)
吉浦 敬 鹿児島大学, 医歯学域医学系, 教授 (40322747)
平野 好幸 千葉大学, 子どものこころの発達教育研究センター, 特任教授 (50386843)
浅野 憲一 千葉大学, 子どものこころの発達教育研究センター, 特任助教 (60583432)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 強迫性障害 / 自閉症スペクトラム障害 / 定量的ＭＲＩ解析 / ＶＢＭ / ＤＴＩ / 治療効果 / 児童思春期 / 自閉スペクトラム障害 / 二次障害 / 認知行動療法 / 定量的ＭＲＩ / 機能的ＭＲＩ / MRI / MRS / 自閉症スペクトラム障害「 / 脳画像 / OCD / ASD / VBM / DTI / CBT |
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| Outline of Final Research Achievements |
In this study, we investigated the difference of brain function between child and adolescent OCD and ASD to contribute to give more evidence about the athophysiology of these two disorders. We used two structural MRI examinations where morphometric of brain was investigated with VBM ( voxel based orphometry) analysis and the features of white matter was investigated with DTI ( diffusion tensor imaging)analysis..Due to the small number of the participants, we were not able to identify any significant brain region in VBM analysis when we applied statistically strict threshold. We, however, found negative correlation between the GM (gray matter) volumes and the AQ ( autism-spectrum quotient) scores in the left cerebellum and the bigger volume in the right insula in OCD patients with comorbid ASD compared with those without it by using loose threshold. In DTI analysis, we found that the significant alterations in the right superior prefrontal gyrus and the right inferior temporal gyrus.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Cognitive-behavioral therapy for obsessive-compulsive disorder with and without autism spectrum disorder: gray matter differences associated with poor outcome.2017
Author(s)
Tsuchiyagaito A, Hirano Y, Asano K, Oshima F, Nagaoka S, Takebayashi Y, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
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Journal Title
Front Psychiatry
Volume: 8
Pages: 143-143
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder2017
Author(s)
Hirose M, Hirano Y, Nemoto K, Sutoh C, Asano K, Miyata H, Matsumoto J, Nakazato M, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
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Journal Title
Brain Imaging and Behavior
Volume: 印刷中
Issue: 5
Pages: 1326-33
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between symptom dimensions and white matter alterations in OCD2017
Author(s)
Yagi M, Hirano Y, Nakazato M, Nemoto K, Ishikawa K, Sutoh C, Miyata H, Matsumoto J, Matsumoto K, Masuda Y, Obata T, Iyo M, Shimizu E, Nakagawa A.
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Journal Title
Acta Neuropsychiatrica
Volume: 印刷中
Issue: 3
Pages: 153-163
DOI
Related Report
Peer Reviewed
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